Nanotechnology In Tissue Engineering Research Articles

Biomedical Approach of Nanotechnology and Biological Risks: A Mini-Review

Nanotechnology has played a prominent role in biomedical engineering, offering innovative approaches to numerous treatments. Notable advances have been observed in the development of medical devices, contributing to the advancement of modern medicine. This article briefly discusses key applications of nanotechnology in tissue engineering, controlled drug release systems, biosensors and monitoring, and imaging and diagnosis. The particular emphasis on this theme will result in a better understanding, selection, and technical approach to nanomaterials for biomedical purposes, including biological risks, security, and biocompatibility criteria.

Scaling down for better periodontal health: The role of nanotechnology

Nanotechnology has emerged as a promising approach in the treatment of periodontal diseases, which affect a large proportion of the population worldwide. By studying nanotechnology, we can gain a better understanding of how these materials can be used in daily practice. Nanotechnology involves the development of materials, devices, and systems that exhibit unique physical, chemical, and biological properties at the nanoscale level. This technology has the potential to revolutionize the prevention, diagnosis, and treatment of oral diseases, including periodontal disease, which affects a significant portion of the global population. The use of nanotechnology in dentistry, also known as Nano dentistry, provides promising solutions for the treatment of various dental disorders, including periodontal disease. This article summarizes the current research trends in periodontal nanotechnology, including nanoscale drug delivery systems and nanomaterials for tissue engineering and regeneration. Nanoparticles offer significant advantages over conventional drug delivery systems due to their controlled release and improved bioavailability, making them a promising approach for periodontitis treatment. Furthermore, nanomaterials act as three-dimensional scaffolds, providing a favourable environment for tissue regeneration by promoting cellular adhesion, proliferation, and differentiation. The potential of nanotechnology in tissue engineering is vast, and its application in bone defect repair and implant success rates has shown great potential. However, safety issues and biological risks must be addressed before routine implementation of nano dentistry in periodontal treatment. Overall, this article provides insights into the potential of nanotechnology in periodontics and its translation into a more specific approach of nano periodontology in periodontology.

Nanotechnology in tissue engineering and regenerative medicine

Nanotechnology in tissue engineering and regenerative medicine

Tissue engineered scaffold fabrication methods for medical applications

Donor shortage for organ transplantations is a major clinical challenge worldwide. Potential risks inevitably encountered with traditional methods include complications, secondary injuries, and, most importantly, limited donor sources. Today, researchers from multiple disciplinary areas, including biomaterials, biology, and nanotechnology in tissue engineering, attempt to bio-fabricate virtually every human tissue or organ. Tissue engineering techniques generally require the use of a porous scaffold, which serves as a three-dimensional template for initial cell attachment and subsequent tissue formation both in vitro and in vivo. The scaffold provides the necessary support for cells to attach, grow, proliferate, and maintain their differentiated function. This article represents a concise summary of different procedures for fabricating sponge-like and fibrous scaffolds using a variety of technologies. First, we will discuss different approaches that allow us to create fibers, which have long been recognized as the primary constituent in 3D scaffolds. These methods include electrospinning and microfluidic-based methods, among others. Following that, the various techniques for fabricating 3D scaffolds, ranging from simple to complex structures, as well as evaluating their advantages and disadvantages, will be explored.

Nanotechnology Assisted Targeted Drug Delivery for Bone Disorders: Potentials and Clinical Perspectives.

Nanotechnology and its allied modalities have brought revolution in tissue engineering and bone healing. The research on translating the findings of the basic and preclinical research into clinical practice is ongoing. Advances in the synthesis and design of nanomaterials along with advances in genomics and proteomics, and tissue engineering have opened a bright future for bone healing and orthopedic technology. Studies have shown promising outcomes in the design and fabrication of porous implant substrates that can be exploited as bone defect augmentation and drug-carrier devices. However, there are dozens of applications in orthopedic traumatology and bone healing for nanometer-sized entities, structures, surfaces, and devices with characteristic lengths ranging from tens 10s of nanometers to a few micrometers. Nanotechnology has made promising advances in the synthesis of scaffolds, delivery mechanisms, controlled modification of surface topography and composition, and biomicroelectromechanical systems. This study reviews the basic and translational sciences and clinical implications of the nanotechnology in tissue engineering and bone diseases. Recent advances in NPs assisted osteogenic agents, nanocomposites, and scaffolds for bone disorders are discussed.

Application of Nanotechnology in Tissue Engineering

Nanomaterials display altered compound and physical properties that enable them to collaborate with the natural frameworks at the cell and atomic levels. This cooperation improves the biomedical uses of nanotechnology in the field of tissue recovery. A wide scope of nanomaterials made of natural and inorganic composites could act naturally amassed in nano scale size that reproduces all the more precisely the elements of the common human tissues, for example, nanoparticles, nanosurfaces and nanoscaffolds. These tale nanomaterials essentially impact the conduct and improvement of undeveloped cells. The utilizations of nanotechnology in explicit tissue recovery, for example, bone, ligament, cardiovascular and neural tissues were explored by a few analysts. Nanostructures have been utilized to advance undifferentiated organism suitability, expansion and separation. Nanotechnology gives biodegradable and biocompatible biomimetic creates that reestablish and improve the tissue capacities. Nanocomposition and nanotopography of a tissue designed material decide the embed destiny giving 3 dimentional tissue culture frameworks that advance typical cell development and separation without antagonistic tissue response. Late advancement in the combination permits the refined cells to respond to the inward and outside boosts and to trade the flagging elements between those cells and the outer condition. In any case, further comprehension to the collaborations of nanomaterials with the natural framework and more examinations of the security of these nanostructures are yet required before their full application in human tissue fixation.

Role of Modern Technologies in Tissue Engineering

: Nanotechnology is a rapidly developing field with numerous applications spread in different fields, especially medicine. It plays a role in tissue engineering, tissue regeneration, drug delivery, and regenerative medicine. The present brief review summarizes the role of nanotechnology in tissue engineering and tissue regeneration. The CRISPR/Cas9 system in tissue engineering is playing an important role, as CRISPR is a revolutionary genome-editing technology that is being used for tissue engineering where it emphasizes to address tissue architecture formation, immune response circumvention, cell differentiation, and disease model development. Moreover, the development and research expenses for tissue engineering and regenerative medicine are too high and there is a need for making these systems cost-effective. Thus, the advanced approach of applications of nanotechnology to regenerative medicine and CRISPR will definitely revolutionize the basis of treatment, prevention, and diagnosis of various diseases.

The role of nanotechnology in induced pluripotent and embryonic stem cells research.

This paper reviews the recent studies on development of nanotechnology in the field of induced pluripotent and embryonic stem cells. Stem cell therapy is a promising therapy that can improve the quality of life for patients with refractory diseases. However, this option is limited by the scarcity of tissues, ethical problem, and tumorigenicity. Nanotechnology is another promising therapy that can be used to mimic the extracellular matrix, label the implanted cells, and also can be applied in the tissue engineering. In this review, we briefly introduce implementation of nanotechnology in induced pluripotent and embryonic stem cells research. Finally, the potential application of nanotechnology in tissue engineering and regenerative medicine is also discussed.

Nanotechnologies in tissue engineering

AbstractAs an interdisciplinary field, tissue engineering (TE) aims to regenerate tissues by combining the principles of cell biology, material science, and biomedical engineering. Nanotechnology creates new materials that might enable further tissue-engineering applications. In this context, the introduction of nanotechnology and nanomaterials promises a biomimetic approach by mimicking nature. This review summarizes the current scope of nanotechnology implementation possibilities in the field of tissue engineering of bone, muscle, and vascular grafts with forms on nanofibrous structures.

Nanotechnology in Tissue Engineering and Regenerative Medicine

Tissue Engineering Part B: ReviewsVol. 18, No. 1 Book ReviewNanotechnology in Tissue Engineering and Regenerative MedicineBalaji SitharamanBalaji SitharamanSearch for more papers by this authorPublished Online:24 Jan 2012https://doi.org/10.1089/ten.teb.2011.1501AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View article"Nanotechnology in Tissue Engineering and Regenerative Medicine." , 18(1), p. 76FiguresReferencesRelatedDetailsCited by3D Printing of Micro- and Nanoscale Bone Substitutes: A Review on Technical and Translational Perspectives1 June 2021 | International Journal of Nanomedicine, Vol. Volume 16 Volume 18Issue 1Feb 2012 InformationCopyright 2012, Mary Ann Liebert, Inc.To cite this article:Balaji Sitharaman.Nanotechnology in Tissue Engineering and Regenerative Medicine.Tissue Engineering Part B: Reviews.Feb 2012.76-76.http://doi.org/10.1089/ten.teb.2011.1501Published in Volume: 18 Issue 1: January 24, 2012Online Ahead of Print:December 9, 2011PDF download

Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface

During the last decade, due to advances in functionalization chemistry, novel nanobiomaterials with applications in tissue engineering and regenerative medicine have been developed. These novel materials with their unique physical and chemical properties are bioactive hierarchical structures that hold great promise for future development of human tissues. Thus, various nanomaterials are currently being intensively explored in the directed differentiation of stem cells, the design of novel bioactive scaffolds, and new research avenues towards tissue regeneration. This paper illustrates the latest achievements in the applications of nanotechnology in tissue engineering in the field of regenerative medicine.

Nanotechnological strategies for engineering complex tissues

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.