Nanotechnology In Diagnosis Research Articles

Advanced Characterization and Sample Preparation Strategies for Nanoformulations

The escalating impact and remarkable progress of nanotechnology have shifted the paradigms of medicine and the healthcare system. Nanosystems have emerged, extensively holding the potential to advance disease diagnosis and treatment specificity. The extraordinary attributes imparted by nano-systems have helped in overcoming the limitations of conventional interventions to an extent and led to targeted therapy, to name one. The role of nanotechnology in diagnosis is another breakthrough in its appellation. This article aims to address the current characterization and sample preparation techniques for the analysis of nanosystems and provide insights into novel methodologies and in situ instrumentation that have eased sampling procedures.

Emerging Applications of Nanotechnology in Healthcare and Medicine.

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There are also potential uses in designing medical tools and processes for the new generation of medical scientists. The main objective for conducting this research review is to gather the widespread aspects of nanomedicine under one heading and to highlight standard research practices in the medical field. Comprehensive research has been conducted to incorporate the latest data related to nanotechnology in medicine and therapeutics derived from acknowledged scientific platforms. Nanotechnology is used to conduct sensitive medical procedures. Nanotechnology is showing successful and beneficial uses in the fields of diagnostics, disease treatment, regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, and therapeutics. A thorough association of and cooperation between physicians, clinicians, researchers, and technologies will bring forward a future where there is a more calculated, outlined, and technically programed field of nanomedicine. Advances are being made to overcome challenges associated with the application of nanotechnology in the medical field due to the pathophysiological basis of diseases. This review highlights the multipronged aspects of nanomedicine and how nanotechnology is proving beneficial for the health industry. There is a need to minimize the health, environmental, and ethical concerns linked to nanotechnology.

Application of nanotechnology in diagnosis, prevention, and treatment of the fish diseases

The occurrence of the disease is one of the main threats to the intensive aquaculture system. With the development of the aquaculture industry, it is expected that the fish will encounter various infectious and non-infectious diseases. In addition to treatment costs, the use of antibiotics in the control of infectious diseases can also cause resistance in bacteria. Therefore, today, the use of additives such as vitamin and mineral supplements, probiotics, prebiotics, and various nanoparticles to improve the growth performance and health of fish, increase the performance of the fish immune system, and resistance to diseases has expanded. The aim of this study was the investigation of the use of anotechnology in aquaculture and effect of it on fish species health, the use of them in nanocarrieres, nanovaccine, nanosensores, etc. According to the increasing trend of studies in the field of nanotechnology, we can hope to provide other new methods in the field of health management of fish farms and prevent damages caused by the occurrence of diseases in the aquaculture industry.

Nanotechnology in COVID-19 Diagnosis and Treatment: A Bibliometric Analysis

There is an utmost urgency of having new and advanced diagnostics as well as therapeutic alternatives along with the conventional methods to treat coronavirus disease 2019 (COVID-19). For this purpose, different strategies must be explored for the advancement of testing capacity, developing effective treatments, and developing safe vaccines that provide long-term immunity. Nanotechnology has been found effective against COVID-19 in terms of diagnosis, prevention, and treatment. The diameter of SARS-CoV-2 (60–140 nm) is similar to nanoparticles. This is why, synthetic nanoparticles can precisely resemble SARS-CoV-2, and efficiently interact with the viral proteins and counter this virus. Nanotechnology offers benefits by developing efficient and cost-effective diagnosis methods and facilitating the improvement of drug properties through nano-carriers, namely liposomes, micelles, metallic nanoparticles, etc. The bibliometric analysis evaluates scholarly contributions using mathematical and statistical methodologies. In this study, the bibliometric analysis investigated the publication trends of nanoparticles and their application in COVID-19 diagnosis and treatment. We have systematically searched the different search engines and publishers (Scopus, PubMed, and Google scholar) from 2020 to 2021, and various visual maps were generated to show, the most- relevant authors, sources, countries, topics, and keywords by using a software called VOSviewer. The findings indicate the advancement of nanotechnology in the diagnosis and therapy of COVID-19. At last, the bibliometric analysis of nanoparticles for COVID-19 diagnosis and treatment provides a clear view of the future research directions and identifies the potential challenges and opportunities. This may pave the way for new researchers to find the proper subfields in nanoparticle-related research areas for combating the COVID-19. Bangladesh Pharmaceutical Journal 25(2): 199-208, 2022 (July)

Nanotechnology in diagnosis and therapy of gastrointestinal cancer.

Advances in nanotechnology have opened new frontiers in the diagnosis and treatment of cancer. Nanoparticle-based technology improves the precision of tumor diagnosis when combined with imaging, as well as the accuracy of drug target delivery, with fewer side effects. Optimized nanosystems have demonstrated advantages in many fields, including enhanced specificity of detection, reduced toxicity of drugs, enhanced effect of contrast agents, and advanced diagnosis and therapy of gastrointestinal (GI) cancers. In this review, we summarize the current nanotechnologies in diagnosis and treatment of GI cancers. The development of nanotechnology will lead to personalized approaches for early diagnosis and treatment of GI cancers.

Review on Nanotechnology in Diagnosis and Detection of Disease

The recent review conversed about nano-technology. Nanotechnology is very important in the diagnosis and detection of disease, as nanotechnology is the fifth generation that appeared in the world of electronics, the first generation represented in the use of the electronic lamp, including television, then the discovery of the transistor, and the spread of its wide applications and then the use of integrated circuits, which is a very small piece. Nanotechnology today has reduced the size of many devices, increased their efficiency and numbered their functions. Then the microprocessor, which made a huge revolution in the field of electronics by producing personal computers and silicon chips, and then nanotechnology. Nano-size as the material is made by light etching, cutting, scraping and grinding. Chemical methods can be used that start with single molecules as smaller A unit and assembled into a larger structure. The properties of nanomaterials can be examined and studied and their composition is confirmed using a number of devices and techniques.

Using Nanotechnology for Diagnosis and Treatment of Breast Cancer: A Review

One of the leading causes of death in women around the word is breast cancer. For the treatment of most cancers, chemotherapy is a good option. The most treatment approaches for breast cancer are radiotherapy, surgery and chemotherapy. There are some restrictions and limitations in diagnostic approaches and treatment methods. They result in the progress of new diagnosis and treatment approaches to improve the life quality of patients. Application of nanotechnology in the treatment of cancers currently has received much attention. In cancer treatments, nanotechnology plays a significant role in the drug delivery. Tumors can be targeted by nanoparticles. They have important role in controlling the drug release to accurate sites. Therefore, nanoparticles improve the drug efficiency and reduce the normal organ’s toxicity. Another ability of nanoparticles is activation of immune cells against tumors. As a result, nanoparticles can be used as a proper and efficient tool in the treatment and diagnosis of cancer. In this review we discuss about using nanotechnology and application of different nanoparticles in diagnosis and treatment of breast cancer.

Nanotechnology: A Novel Approach for Drug Development in Health Care System

Background: Health is a lively state of the body which adjusts and adopt with the response to various environmental changes. There are several features that can influence the health status of human beings. Therefore, the continuous research study is highly essential to maintain a proper health care system in the community. Objective: The diverse area of innovation was made in nanotechnology for diagnosis and treatment of life-threatening diseases, such as obesity, diabetes, cardiovascular disorders, cancer, leukemia, neurodegenerative disorders like Alzheimer's disease and Parkinson's diseases, etc. Nanotechnology generally refers to the materials, devices, and systems in nanoscale which provides considerably improved physical, chemical and biological property. Methods: It is technology which deals with the design, synthesis, characterization of substances, devices and systems by arranging shape and size at their nanometer scale. It involves multidisciplinary research which includes both health science and technology for the treatment of human health. Nanotechnology can be applied at the cellular level in the human body with a high degree of specificity to treat the various diseases. Conclusion: This technology is potentially targeted to diseased tissue to achieve maximum therapeutic efficacy with fewer side effects. Nowadays, the rapidity of revolutionary discoveries in the field of nanotechnology is expected to accelerate in the next decade globally.

Oral and Intra-nasal Administration of Nanoparticles in the Cerebral Ischemia Treatment in Animal Experiments: Considering its Advantages and Disadvantages.

BackgroundOver the past few decades, nanotechnology has dramatically advanced; from the precise strategies of synthesizing modern nanostructures to methods of entry into the body. Using nanotechnology in diagnosis, drug delivery, determining signaling pathways, and tissue engineering is great hope for the treatment of stroke. The drug-carrying nanoparticles are a way to increase drug absorption through the mouth or nose in treating the stroke.ObjectiveIn this article, in addition to explaining pros and cons of oral and intra-nasal administration of nanoparticles in the brain ischemia treatment of animal models, the researchers introduce some articles in this field and briefly mentioned their work outcomes.MethodsA number of relevant published articles 183 were initially collected from three popular databases including PubMed, Google Scholar, and Scopus. The articles not closely related to the main purpose of the present work were removed from the study process. The present data set finally included 125 published articles.ResultsDirect delivery of the drug to the animal brain through the mouth and nose has more therapeutic effects than systemic delivery of drugs. The strategy of adding drugs to the nanoparticles complex can potentially improve the direct delivery of drugs to the CNS.ConclusionDespite the limitations of oral and intra-nasal routes, the therapeutic potential of oral and intra-nasal administration of nano-medicines is high in cerebral ischemia treatment.

Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases

AbstractCentral nervous system (CNS) diseases, mainly including neurodegenerative diseases and psychiatric diseases, have become the leading cause of death and disability in the world today, which bring huge suffering to both patients and their families. Nanomedicine is an emerging and rapidly evolving discipline that mainly involves the application of nanoparticles in the diagnosis and treatment of various diseases. Although many challenges in the clinical application of nanomedicine still exist, the prospects for development cannot be ignored. Furthermore, better outcomes for patients with CNS diseases can be expected with the rapid development of nanotechnology in diagnosis and treatment. In the present review, an overview is given of the outstanding recent progress of nanomedicine from three aspects: drug delivery, imaging, and therapy in CNS diseases.

Nanoscience in Multiple Sclerosis

Multiple Sclerosis (MS) - the most common autoimmune disease of the central nervous system – is traditionally diagnosed by methods mainly using magnetic resonance techniques to detect the lesions. Use of nanoparticles as the contrast agents can help in better diagnosis of the damaged cells. Iron nanoparticles are used in various advanced techniques like superparamagnetic iron oxide nanoparticles (SPIONs) and ultra-small SPIONs (USPIONs). The major challenge in treatment of MS is the delivery of the drug into the brain, crossing the blood brain barrier (BBB). Nanoparticles like liposomes, nanoshells, dendrimers, nanogels, micelles have potential applications in the same. Presently, no significant treatment is devoid of side effects like fever, headache and fatigue, Use of nanoscience in MS in drug delivery and treatment can help solve the prevailing inadequacies. Administered quantum dots conjugated with self-antigens act on lymph nodes and spleen. These assemblies produce regulatory T-cells which prevent degeneration of myelin sheath. New studies study modifications to produce inflammation-resistant myelin by inducing response in lymph nodes during T-cell priming. This review aims to briefly describe the application of nanotechnology in diagnosis, drug delivery and treatment of MS.

Modern Nanomaterials and Nanotechnology in Diagnosis and Treatment of Malignant Tumors of Gastrointestinal Tract

Modern Nanomaterials and Nanotechnology in Diagnosis and Treatment of Malignant Tumors of Gastrointestinal Tract

Application of Nanotechnology in Diagnosis and Disease Management of White Spot Syndrome Virus (WSSV) in Aquaculture

Nanotechnology a multidisciplinary field involves the design and production of functional systems at the molecular level. In aquaculture, the application of nanotechnology it’s still at infant stage and it potent enough to solve many issues related to nutrition, animal production, reproduction, disease diagnosis, prevention and treatment. Worldwide, during the last decade though shrimp culture has been one of the most prevalent practices in marine industry and it has been threatened by viral diseases frequently. Among various shrimp viral pathogens, white spot syndrome virus (WSSV) is exceedingly pathogenic and conscientious for huge economic loss in shrimp culture industry. In this review, the application of nanotechnology in diagnosis and management of WSSV in aquaculture is discussed in detail.

Functional Microparticle R&D for IVD and Cell Therapeutic Technology: Large-Scale Commercialized Products

The global R&D of functional materials have become more prominent and are expected to increase with a high growth rate through 2022. High demand due to current and emerging applications, superior structural properties, and the development of advanced fabrication methods is accelerating and driving the functional materials market. The functional materials are segmented based on application into construction composites, medical technology, cosmetics & personal care, oil & gas, automotive, life science & technology, and other categories. In particular, the use of microparticles as functional materials is continually increasing in the field of medicine and the healthcare industry. Nanotechnology for diagnosis, monitoring, drug delivery, treatment and control of biological systems is the leading application in the microparticle market, causing the growing demand for new types of microparticles. Furthermore, growing medical and healthcare industries will increase the worldwide demand for new functional microparticles in biomedical technology applications. This review paper will discuss the main aspects of state-of-the-art functional microparticles research, while demonstrating the broad variety of applications in the fields of diagnostics and therapy, especially in large-scale commercialized products related to magnetic microparticles in IVD and to microcarriers in cell therapeutics.

A Review on Nanotechnology in Diagnosis and Treatment of Alzheimer’s Disease

A Review on Nanotechnology in Diagnosis and Treatment of Alzheimer’s Disease

Application and significance of molecular targeted nanotechnology in diagnosis and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignancies. Current radiological examination is quite limited in diagnosing early HCC. Various treatments for HCC have definite indications, and there is still no effective treatment and prevention for recurrence and metastasis. Based on the recent development of molecular targeting nanotechnology for specific molecules in liver cancer cells, early diagnosis and the monitoring of recurrence and metastasis for HCC can be improved, and the specificity of drug in targeting cancer cells and the therapeutic effect on HCC can be significantly enhanced. The article reviewed the application and significance of molecular targeting nanotechnology in HCC diagnosis and treatment. Key words: Hepatocellular carcinoma; Molecular targets; Nanotechnology; Early diagnosis; Target therapy

Nanotechnology in Diagnosis: A Review

The fast pace of today’s world has presented several challenges in the area of healthcare. Depression, hypertension, diabetes, cancers and several infectious diseases are just some of the common outcomes associated with the high speed stress-filled lifestyle. Early diagnosis has been the goal for prompt arrest and management of these health conditions. This has been a challenge in recent times. However, great scientific advancement with improved potential in medical diagnosis has equally been a giant stride in times like these. Early disease detection even before symptoms’ presentation, improved imaging of internal body structure, as well as ease of diagnostic procedures, have been developed with the help of a new branch of laboratory medicine termed nanodiagnostics. Use of microchips, biosensors, nanorobots, nano identification of single celled structures, and microelectromechanical systems are current techniques being developed for use in nanodiagnostics. This piece of write up takes a panoramic view of available nanotechnological advances in current use for medical diagnosis and projecting into future possibilities and potentials for an improved health care delivery.

Use of Nanotechnology in Diagnosis and Treatment of Hepatic Fibrosis: A Review

Liver fibrosis is an important cause of morbidity and mortality worldwide and represent a difficult clinical challenge of global importance. The liver fibrosis progression needs to be controlled because persisted liver fibrosis can lead to liver cirrhosis or even hepatocellular carcinoma. Despite significant advances in the understanding of the liver fibrosis development, the therapeutic effect of drugs used in liver fibrosis treatment is not sufficient. Today, nanotechnology has been considered as a potential tool for developing novel drug delivery systems for the improved imaging and various diseases, including liver fibrosis. In this article, we discussed the use of nanotechnology for the treatment and imaging of liver fibrosis.

Nanotechnology in diagnosis and treatment of coronary artery disease.

Nanotechnology could provide a new complementary approach to treat coronary artery disease (CAD) which is now one of the biggest killers in the Western world. The course of events, which leads to atherosclerosis and CAD, involves many biological factors and cellular disease processes which may be mitigated by therapeutic methods enhanced by nanotechnology. Nanoparticles can provide a variety of delivery systems for cargoes such as drugs and genes that can address many problems within the arteries. In order to improve the performance of current stents, nanotechnology provides different nanomaterial coatings, in addition to controlled-release nanocarriers, to prevent in-stent restenosis. Nanotechnology can increase the efficiency of drugs, improve local and systematic delivery to atherosclerotic plaques and reduce the inflammatory or angiogenic response after intravascular intervention. Nanocarriers have potential for delivery of imaging and diagnostic agents to precisely targeted destinations. This review paper will cover the current applications and future outlook of nanotechnology, as well as the main diagnostic methods, in the treatment of CAD.

What Is the Role of Nanotechnology in Diagnosis and Treatment of Metastatic Breast Cancer? Promising Scenarios for the Near Future

Metastatic breast cancer represents a diagnostic and therapeutic challenge due to tumor heterogeneity and to various physiological barriers that hinder drug delivery to the metastatic sites. To overcome these limitations, nanoformulated drugs have been developed and tested in preclinical studies, and few of them have been successfully translated into clinical practice. In particular, liposomal anthracyclines and nanoformulated albumin-bound paclitaxel have revealed an improved therapeutic index when compared to conventional chemotherapy, with significant reduction of drugs toxicity. Several strategies for nanoparticles engineering have more recently been explored to increase selectivity for tumor cells and to reach poorly accessible metastatic districts. Targeted nanoparticles, directed toward tumor markers and tissue-specific metastases, may provide effective devices in case of low-vascularized and small-sized metastases, thus paving the way for a real change in the natural history of metastatic disease. A number of targets have been identified and exploited for surface functionalization of different types of nanoparticles, which are currently undergoing preclinical studies. The aim of this review is to provide an overview of current nanotechnology applied to metastatic breast cancer diagnosis and treatment. Promising results encourage an upcoming translation of this research into clinical practice for an effective management of the disease in the near future.