Nanosensor Technology Research Articles

Recent Patents on Nanosensor for Tumor Biomarker Detection

Since the cancer has been the biggest threat to our human beings’ health, more and more new patents of medical treatments for cancer detection have been used to make us out of suffering from cancer. Currently, most of patients check out their cancer cell at the late stage when cure is difficult, so early detection of cancer has been demonstrated to significantly important for improving clinical outcomes. But the current clinical methods available for such assessments are slow, expensive and inaccurate. There is a new development of nanosensor technology which makes it possible to detect the tumor earlier. The present paper summarizes some new discoveries of nanosenor for tumor biomarker detection which allow for low-cost, minimally invasive approach with high sensitivity and specificity by detecting tumor biomarkers from the exhaled breath, proteomic, and molecule etc.

Interview: Revolutionizing personalized medicine with nanosensor technology.

Perena Gouma, PhD, is a Fulbright Scholar and tenured Associate Professor at the Department of Materials Science and Engineering at the State University of New York Stony Brook, NY, USA. Dr Gouma is a lead researcher in sensor technology, and recently developed a new nanomedicine tool called the 'Nanosensor Device for Breath Acetone Detection', which makes it possible to instantly detect and monitor disease by simply exhaling into a handheld device. Dr Gouma received a BS degree in Applied Physics from the Aristotelian University of Thessaloniki, Greece, a MS in Advanced Engineering Materials and an MPhil in Organizational Management, both from the University of Liverpool (UK), and a PhD in Materials Science & Engineering from the University of Birmingham (UK).

Electromagnetic wireless nanosensor networks

This paper provides an in-depth view on nanosensor technology and electromagnetic communication among nanosensors. First, the state of the art in nanosensor technology is surveyed from the device perspective, by explaining the details of the architecture and components of individual nanosensors, as well as the existing manufacturing and integration techniques for nanosensor devices. Some interesting applications of wireless nanosensor networks are highlighted to emphasize the need for communication among nanosensor devices. A new network architecture for the interconnection of nanosensor devices with existing communication networks is provided. The communication challenges in terms of terahertz channel modeling, information encoding and protocols for nanosensor networks are highlighted, defining a roadmap for the development of this new networking paradigm.

New foundation focused on the early detection of cancer

New foundation focused on the early detection of cancer

Circular permutation of ligand‐binding module improves dynamic range of genetically encoded FRET‐based nanosensor

Quantitative measurement of small molecules with high spatiotemporal resolution provides a solid basis for correct understanding and accurate modeling of metabolic regulation. A promising approach toward this goal is the FLIP (fluorescent indicator protein) nanosensor based on bacterial periplasmic binding proteins (PBPs) and fluorescence resonance energy transfer (FRET) between the yellow and cyan variants of green fluorescent protein (GFP). Each FLIP has a PBP module that specifically binds its ligand to induce a conformation change, leading to a change in FRET between the two GFP variant modules attached to the N- and C-termini of the PBP. The larger is the dynamic range the more reliable is the measurement. Thus, we attempted to expand the dynamic range of FLIP by introducing a circular permutation with a hinge loop deletion to the PBP module. All the six circularly permutated PBPs tested, including structurally distinct Type I and Type II PBPs, showed larger dynamic ranges than their respective native forms when used for FLIP. Notably, the circular permutation made three PBPs, which totally failed to show FRET change when used as their native forms, fully capable of functioning as a ligand binding module of FLIP. These FLIPs were successfully used for the determination of amino acid concentration in complex solutions as well as real-time measurement of amino acid influx in living yeast cells. Thus, the circular permutation strategy would not only improve the performance of each nanosensor but also expand the repertoire of metabolites that can be measured by the FLIP nanosensor technology.

Matrix-insensitive protein assays push the limits of biosensors in medicine

Advances in biosensor technologies for in vitro diagnostics have the potential to transform the practice of medicine. Despite considerable work in the biosensor field, there is still no general sensing platform that can be ubiquitously applied to detect the constellation of biomolecules in diverse clinical samples (for example, serum, urine, cell lysates or saliva) with high sensitivity and large linear dynamic range. A major limitation confounding other technologies is signal distortion that occurs in various matrices due to heterogeneity in ionic strength, pH, temperature and autofluorescence. Here we present a magnetic nanosensor technology that is matrix insensitive yet still capable of rapid, multiplex protein detection with resolution down to attomolar concentrations and extensive linear dynamic range. The matrix insensitivity of our platform to various media demonstrates that our magnetic nanosensor technology can be directly applied to a variety of settings such as molecular biology, clinical diagnostics and biodefense.

Nanosensors: a review of recent research

PurposeThe purpose of this paper is to provide a technical review of recent nanosensor research.Design/methodology/approachThis paper describes a number of nanosensor research themes and recent development activities, with an emphasis on work conducted or reported since 2006. It considers a range of emerging nanosensing technologies and two specific areas of application.FindingsThis paper shows that nanosensor technology is developing rapidly and is the subject of a global research effort. Technologies such as nano‐electromechanical system, nano‐opto‐electromechanical system, nanophotonics and the combination of nanotechnology with microtechnology offer prospects to yield sensors for a wide range of chemical, biochemical and physical variables in applications which include healthcare, defence and homeland security, environmental monitoring and light sensing and imaging.Originality/valueThis paper provides a technically detailed, up‐to‐date account of recent nanosensor research.

Carbon Nanotube Based Chemical Sensors for Space and Terrestrial Applications

A nanosensor technology has been developed using nanostructures, such as single walled carbon nanotubes (SWNTs), on a pair of interdigitated electrodes (IDE) processed with a silicon-based microfabrication and micromachining technique. These sensors have been exposed to nitrogen dioxide, acetone, benzene, nitrotoluene, chlorine, and ammonia in the concentration range of ppm to ppb at room temperature. Due to the large surface area, low surface energy barrier and high thermal and mechanical stability, nanostructured chemical sensors potentially can offer higher sensitivity, lower power consumption and better robustness than the state-of-the-art systems, which make them more attractive for defense and space applications. Combined with MEMS technology, lightweight and compact size sensors can be made in wafer scale with low cost. Additionally, a wireless capability of such a sensor chip can be used for networked mobile and fixed-site detection and warning systems for military bases, facilities and battlefield areas.

Large deflection analysis of orthotropic, elliptic membranes

Applications of membrane mechanisms are widely found in nano-devices and nano-sensor technologies nowadays. An alternative approach for large deflection analysis of the orthotropic, elliptic membranes - subject to gravitational, uniform pressures often found in nano-sensors - is described in this paper. The material properties of membranes are assumed to be orthogonally isotropic and linearly elastic, while the principal directions of elasticity are parallel to the coordinate axes. Formulating the potential energy functional of the orthotropic, elliptic membranes involves the strain energy that is attributed to inplane stress resultant and the potential energy due to applied pressures. In the solution method, Rayleigh-Ritz method can be used successfully to minimize the resulting total potential energy generated. The set of equilibrium equations was solved subsequently by Newton-Raphson. The unparalleled model formulation capable of analyzing the large deflections of both circular and elliptic membranes is verified by making numerical comparisons with existing results of circular membranes as well as finite element solutions. The results are found in excellent agreements at all cases. Then, the parametric investigations are given to delineate the impacts of the aspect ratios and orthotropic elasticity on large static tensions and deformations of the orthotropic, elliptic membranes.

Nanosensor technology for following phosphate partitioning in plants

This article was submitted without an abstract, please refer to the full-text PDF file.

Sensing the importance of nanosensors: Feynman's visionary 1959 Christmas lecture

Just after Christmas 1959, R. Feynman delivered a nowfamous talk – titled “There’s Plenty of Room at the Bottom” – at the California Institute of Technology [6]. Could it be possible, he asked, for scientists to assemble new materials at the level of single atoms and molecules, where there are “new kinds of forces and new kinds of possibilities, new kinds of effects”? It’s generally accepted that Feynman’s visionary discussion of the problems and promise of miniaturisation constituted the starting point for the new field that today is called nanotechnology. What could Feynman say about the realization of his predictions at present? Nanotechnology undoubtedly will have applications in medicine, electronics and chemistry. Nanostructures are used within the EU Integration Project SENSATION, which is aimed “to explore a wide range of microand nanosensor technologies” for “monitoring, detection and prediction of human physiological state in relation to sleep and awakefullness, fatigue and stress” [9]. Nanoparticles are unique tools as sensors. First, they are larger than typical molecules yet smaller than viruses. They are similar in size to many proteins. This is part of the reason they can operate well inside cells. Second,nanosensors possess unique physical characteristics. They deliver sensitivity orders of magnitude better than conventional devices and provide such performance advantages as fast response time and portability. For example, nanoshells [7] and nanorice [12] are Vorahnung der Bedeutung von Nanosensoren: Der visionare 1959 Weihnachtsvortrag von Feynman

Special issue on Nanosensor Technology

Special issue on Nanosensor Technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Special issue on Nanosensor Technology

Special issue on Nanosensor Technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Special issue on nanosensor technology

Binding Dynamics of Hepatitis C Virus' NS5A Amphipathic Peptide to Cell and Model Membranes

Membrane association of the hepatitis C virus NS5A protein is required for viral replication. This association is dependent on an N-terminal amphipathic helix (AH) within NS5A and is restricted to a subset of host cell intracellular membranes. The mechanism underlying this specificity is not known, but it may suggest a novel strategy for developing specific antiviral therapy. Here we have probed the mechanistic details of NS5A AH-mediated binding to both cell-derived and model membranes by use of biochemical membrane flotation and quartz crystal microbalance (QCM) with dissipation. With both assays, we observed AH-mediated binding to model lipid bilayers. When cell-derived membranes were coated on the quartz nanosensor, however, significantly more binding was detected, and the QCM-derived kinetic measurements suggested the existence of an interacting receptor in the target membranes. Biochemical flotation assays performed with trypsin-treated cell-derived membranes exhibited reduced AH-mediated membrane binding, while membrane binding of control cytochrome b5 remained unaffected. Similarly, trypsin treatment of the nanosensor coated with cellular membranes abolished AH peptide binding to the cellular membranes but did not affect the binding of a control lipid-binding peptide. These results therefore suggest that a protein plays a critical role in mediating and stabilizing the binding of NS5A's AH to its target membrane. These results also demonstrate the successful development of a new nanosensor technology ideal both for studying the interaction between a protein and its target membrane and for developing inhibitors of that interaction.

Aerospace Environmental Monitoring Using Oxide Based Micro and Nano Sensor Technology

not Available.

Special issue on nanosensor technology

Special issue on nanosensor technology