Three dimensional Single Molecule Switching Nanoscopy (SMSN) imaging beyond the coverslip surface poses significant challenges. One of the major obstacles is that the sample-induced aberrations distort and blur single molecule emission patterns, known as Point Spread Functions (PSFs). These distortions and blurring make three-dimensional (3D) inference of single molecule positions unreliable. Adaptive Optics (AO) assisted SMSN developments helped push the volumetric 3D-SMSN imaging depth to a whole cell sample, however, to date robust 3D SMSN reconstruction of more than a couple layers of cells or tissues remains a practical challenge due to the permanent information loss caused by aberrations induced by fixed or living specimens. Here, we introduce a method combining adaptive PSF engineering and an efficient adaptive optics routine to allow simultaneous correction of sample-induced aberrations and enforcement a consistent PSF response through large depths, therefore permitting robust 3D-super-resolution volumetric imaging of fluorescence stained whole-cell samples or tissues. We show that our method allows imaging through 30 μm brain sections from the mouse frontal cortex by reconstructing fibrillar amyloid-β plaques found in Alzheimer's disease.