The requirements of quantum metrology and nanoscience are driving the need forsingle-particle detection capability across a wide variety of physics areas, includingquantum information processing, single-photon detection, nanoelectromechanicalsystems, nanomagnetism and spintronics. The single particles to be detected includeatoms, molecules, photons, spins and even phonons, in the future. Nanoscalesuperconducting quantum interference devices (nanoSQUIDs) represent a newmanifestation of an old but exciting superconducting technology which addresses someof these requirements. In this paper we describe a straightforward approach tofabricating Nb microbridge weak links using combined optical lithography andfocused ion beams which may be used to fabricate nanoSQUIDs. The devices shownon-hysteretic current–voltage characteristics and demonstrate very low noise,even at operating temperatures above 4.2 K. To improve our understanding of thesuperconducting properties of the Josephson microbridge/nanobridge junctions which haveproved very successful in realizing low noise nanoSQUIDs we have carried out acombination of investigations. These include cryogenic resistance versus temperature (R(T)) and current–voltage characteristic measurements, atomic force microscope scans,controlled gallium (Ga) ion milling and implantation, and ion beam track modelling ofthese Josephson devices and Nb thin films.