Nanoporous Acid Catalyst Research Articles

Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst.

A simple, efficient, and environmentally friendly method has been developed for the synthesis of a series of tricyclic fused pyrazolopyranopyrimidines via a one-pot three-component reaction of barbituric acids, aromatic aldehydes, and 3-methyl-5-pyrazolone in the presence of SBA-Pr-SO3H. SBA-15 mesoporous silica material functionalized with propyl sulfonic acid groups was used as a heterogeneous Brønsted acid catalyst with hexagonal structure, high surface area, thick walls, and large uniform pores. All reactions were performed under reflux conditions in water in the presence of a catalytic amount of SBA-Pr-SO3H. High yields, mild reaction conditions, short reaction times, and simple work-up procedures are some advantages of this method. The antimicrobial activities of the synthesized compounds were also evaluated and some products exhibited significant antibacterial activities at low concentrations.

One-pot Synthesis of Benzo[c]acridine Derivatives Using SBA-Pr-SO3H as Nano Catalyst

One-pot synthesis of benzo[c]acridine derivatives via the three-component condensation reaction of aromatic aldehydes, 1-naphtylamine, and dimedone using sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as nanoporous acid catalyst under solvent-free conditions was studied. This reaction is an efficient, green and environmentally friendly procedure.

Three-component one-pot synthesis of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines

Abstract A series of dihydrochromeno[4,3-b]pyrazolo[4,3-e]pyridines has been synthesized using a simple and efficient one-pot, three-component procedure. The products were obtained in good yields in the presence of heterogeneous nanoporous acid catalyst (SBA-Pr-SO3H).

ChemInform Abstract: Application of Sulfonic Acid Functionalized SBA‐15 as a New Nanoporous Acid Catalyst in the Green One‐Pot Synthesis of Spirooxindole‐4H‐pyrans.

AbstractSulfonic acid‐functionalized SBA‐15 is shown to be an efficient catalyst for the three‐component synthesis of title compounds of type (IV).

SYNTHESIS AND BIOLOGICAL EVALUATION OF SPIRO[INDOLINE-3,4'-PYRANO[2,3-C:6,5-C']DIPYRAZOL]-2-ONES IN THE PRESENCE OF SBA-Pr-SO3H AS A NANOCATALYST

Sulfonic acid functionalized SBA-15 nanoporous material (SBA-Pr-SO3H) with a large pore size of 6 nm, a high surface area, high selectivity, and excellent chemical and thermal stability was applied as an efficient heterogeneous nanoporous acid catalyst in the reaction of isatin with pyrazolones under mild reaction conditions. A novel class of symmetrical spiro[indoline-3,4'-pyrano[2,3-c:6,5-c']dipyrazol]-2-one derivatives was successfully obtained in high yields. Comparison of these results with those reported in the literature shows that the current method is efficient, and results in better reaction times and yields of the desired products. Other advantages of this new method are its operational simplicity, easy work-up procedure, and the use of SBA-Pr-SO3H as a reusable and environmentally benign nanoreactor, such that the reaction proceeds easily in its nanopores. We also tested the antimicrobial activity of the prepared compounds using the disc diffusion method, and some of the synthesized compounds exhibited the best results against B. subtilis and S. aureus.

Application of Sulfonic Acid Functionalized SBA‐15 as a New Nanoporous Acid Catalyst in the Green One‐Pot Synthesis of Spirooxindole‐4H‐pyrans

Sulfonic acid functionalized SBA‐15 (SBA‐Pr‐SO3H) as a new nanoporous solid acid catalyst was applied in the green one‐pot synthesis of spirooxindole‐4H‐pyrans via condensation of isatins, malononitrile or methyl cyanoacetate or ethyl cyanoacetate, and 4‐hydroxycoumarin in water solvent. SBA‐Pr‐SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst with a pore size of 6 nm that could be easily handled and removed from the reaction mixture by simple filtration and can be recovered and reused for several times without any loss of activity. The significant merits of present methodology are its simplicity, short reaction time, good yields, and environmentally benign mild reaction condition as water was used as a green solvent.

Application of Sulfonic Acid Functionalized SBA-15 as a Nanoporous Acid Catalyst in Microwave Assisted Synthesis of 2-Aryl Benzoxazoles

Sulfonic acid functionalized SBA-15 as a nanoporous acid catalyst was used in the synthesis of 2-Aryl benzoxazoles 4 by the condensation of 2-aminophenol 1 and benzoyl chlorides 2 under microwave irradiation in solvent free reaction conditions. The advantages of this methodology are good product yields (60-98%), being environmentally benign, short reaction times and easy work up.

Green synthesis of spiro[indoline-3, 9 ′ -xanthene]trione derivatives using sulfonic acid functionalized SBA-15 as a new nanoporous acid catalyst

A simple and efficient method for the synthesis of spiro[indoline-3, 9′-xanthene]trione derivatives has been achieved through the condensation reaction of isatins and two moles of dimedone or 1,3-cyclohexanedione, under solvent-free conditions, in the presence of SBA-15-Pr–SO3H as an efficient heterogeneous nano solid acid catalyst. The features of this procedure are short reaction times, good yields, solvent-free reaction conditions, and simple workup. The absence of solvent allows avoiding the use of toxic organic solvents, which makes this reaction safe and environmentally friendly. Furthermore, the use of SBA-15-Pr–SO3H with a pore size of 6 nm has the advantage of being a nano-reactor in whose nano-pores the reaction proceeds easily.

Efficient green synthesis of isoindigo derivatives using sulfonic-acid-functionalized nanoporous silica (SBA-Pr-SO3H) catalyst and study of their antimicrobial properties

An efficient green condensation reaction has been developed for synthesis of trans-isoindigo derivatives using SBA-Pr-SO3H with pore size of 6 nm as a heterogeneous nanoporous acid catalyst under solvent-free conditions. Isoindigo derivatives have many industrial applications, e.g., dyes, drugs, organic solar cells, and semiconductor memories. The antimicrobial activities of these compounds have also been tested.

Application of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) in the solvent free synthesis of (E)-arylidene-1,3-dihydroindole-2-ones

An efficient and green condensation reaction is developed for the synthesis of ( E )-arylidene-1,3-dihydroindole-2-ones; (1), using heterogeneous nanoporous acid catalyst of SBA-Pr-SO 3 H with pore size, 6 nm in solvent free condition. Arylidene-1,3-dihydroindole-2-ones have many pharmaceutical properties such as Tyrosin kinase inhibiton. This method has the advantages of short reaction time, isolation ease of the products, excellent yields and recyclable catalyst.

One Pot Synthesis of Polyhydroquinolines Catalyzed by Sulfonic Acid Functionalized SBA-15 as a New Nanoporous Acid Catalyst under Solvent Free Conditions

Sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a new nanoporous acid catalyst was used in the one-pot synthesis of polyhydroquinolines derivatives via the Hantzsch four component condensation reaction of aldehydes, β - ketoesters, dimedone and ammonium acetate under solvent free conditions with short reaction time in excellent yields. SBA-Pr-SO3H was proved to be an efficient heterogeneous nanoporous solid acid catalyst (pore size 6 nm), which could be easily handled and removed from the reaction mixture by simple filtration, and also recovered and reused without loss of reactivity.