Metal-organic Framework Nanoparticles Research Articles

Size-Dependent Properties of Solution-Processable Conductive MOF Nanocrystals.

The diverse optical, magnetic, and electronic behaviors of most colloidal semiconductor nanocrystals emerge from materials with limited structural and elemental compositions. Conductive metal-organic frameworks (MOFs) possess rich compositions with complex architectures but remain unexplored as nanocrystals, hindering their incorporation into scalable devices. Here, we report the controllable synthesis of conductive MOF nanoparticles based on Fe(1,2,3-triazolate)2. Sizes can be tuned to as small as 5.5 nm, ensuring indefinite colloidal stability. These solution-processable MOFs can be analyzed by solution-state spectroscopy and electrochemistry and cast into conductive thin films with excellent uniformity. This unprecedented analysis of MOF materials reveals a strong size dependence in optical and electronic behaviors sensitive to the intrinsic porosity and guest-host interactions of MOFs. These results provide a radical departure from typical MOF characterization, enabling insights into physical properties otherwise impossible with bulk analogues while offering a roadmap for the future of MOF nanoparticle synthesis and device fabrication.

Preparation of Ni@UiO-66 incorporated polyethersulfone (PES) membrane by magnetic field assisted strategy to improve permeability and photocatalytic self-cleaning ability

Metal-organic frameworks (MOFs) have been considered as promising nanofillers to fabricate mixed matrix membranes for water treatment. However, manipulating distribution of MOFs nanoparticles in the membrane matrix remains a great challenge. In this study, UiO-66 was firstly coated by magnetic Ni via an in-situ reduction reaction, and then incorporated into polyethersulfone (PES) membrane matrix to prepare PES-Ni@UiO-66 membrane. The magnetic Ni allowed to manipulate the distribution of magnetic Ni@UiO-66 in the phase-inversion process by an external magnetic field. The hydrophilic Ni@UiO-66 can be pulled onto membrane surface by the magnetic force, endowing the prepared membrane with rather higher hydrophilicity. The prepared membrane exhibited superior water permeability with a pure water flux of 611.5 ± 19.8 L·m−2·h−1 and improved antifouling performance. Moreover, benifiting from photocatalytic activity of the exposed Ni@UiO-66 on membrane surface, the obtained PES-Ni@UiO-66 membrane demonstrated excellent photocatalytic self-cleaning ability with a flux recovery rate (FRR) higher than 95% under UV irradiation. Analyzing by extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory indicated that the improved antifouling performance could be attributed to less attractive or even repulsive interaction between the prepared membrane and pollutants. This work provided valuable guidance for structural regulation and development of high-performance MOFs-based membranes for water treatment.

Fabrication of chitosan nanofibrous scaffolds based on tannic acid and metal-organic frameworks for hemostatic wound dressing applications

Here, we developed chitosan (CS)-based nanofibrous scaffold consisting of tannic acid (TA) and zinc-based metal-organic framework (MOF) as a novel antibacterial and hemostatic wound dressing. The effect of MOF content and its incorporation within and onto CS/PVA-TA nanofibrous scaffolds were studied. The morphological characterization of fabricated nanofibrous scaffolds revealed the formation of uniform and bead-free nanofibers with an average diameter between 120 and 150 nm. The uniform and continuous decoration of MOF crystals on nanofibrous scaffold surfaces were confirmed by FESEM. The developed nanofibrous scaffolds exhibit appropriate physicochemical characteristics such as chemical and crystalline structure, surface wettability and swelling, and mechanical properties. It is shown that the incorporation of TA and MOFs greatly enhanced the hemostatic performance of the CS/PVA nanofibrous scaffold by providing rapid liquid absorbability and accelerating the aggregation of coagulation factors and platelets. Furthermore, the results of the MTT assay suggested the good biocompatibility of nanofibrous scaffolds containing MOF nanoparticles. The nanofibrous scaffolds exhibited excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. The disk diffusion antibacterial assay showed that the nanofibrous scaffolds containing TA and MOF could protect wound from bacterial infection. The findings provide new insights to develop a MOF-modified nanofibrous structure with great potential for hemostatic wound dressing application.

Effect of solution chemistry on the stability and transport of ZIF-8 in saturated porous media

Metal-organic frameworks (MOFs) nanoparticles have been regarded as one of the most important materials for high-performance applications in various fields, including environmental protection. Understanding the migration behavior of MOFs in the environmental media is critical for evaluating their opportunities and risks. In this study, the effect of pH, ionic strength, and NOM (fulvic acid and citric acid) were selected to investigate the transport and retention of ZIF-8 in saturated porous media. Experimental results showed that the released Zn2+ of ZIF-8 was significantly increased by the high concentration of ionic strength and citric acid. There were new ZIFs phases detected in the transport process. ZIF-8 had weak mobility with a recovery of transport mass ≈ 2.3% in 1 mg/L citric acid at pH 6, while the maximum effluent recovery was 33.7% in the 100 mM NaCl at pH 8. Under all examined conditions, ZIF-8 was mainly retained at segments near the column inlet. Straining increased the retention of ZIF-8 in porous media. These results indicated that physicochemical factors and particle-specific properties played important roles in influencing ZIF-8 transportability, which would lead to the more complex evaluation of the environmental behaviors of MOFs.

Film-facilitated formation of ferrocenecarboxylic acid-embedded metal-organic framework nanoparticles for sonodynamic osteosarcoma treatment

Sonodynamic therapy (SDT) has stronger penetrating ability compared with phototherapy due to the replacement of excitant from near-infrared light to ultrasound. The effective combination of low-intensity ultrasound and sonosensitizers allows SDT to penetrate deep tissue for the treatment of deep solid tumors. In this research, hybrid metal-organic framework (MOF) nanoparticles (FcCOOH-ZnTCPP, FcCOOH: ferrocenecarboxylic acid, TCPP: tetra(4-carboxyphenyl)porphyrin) are synthesized by a simple film technology, demonstrating outstanding acoustic response characteristics. FcCOOH is directly embedded in the nanoparticles during the formation process of FcCOOH-ZnTCPP, where FcCOOH catalyzes excess hydrogen peroxide in the tumor microenvironment to oxygen for increasing the SDT effect. Hybrid MOF nanoparticles with good biocompatibility and internalization ability to tumor cells present enhanced therapeutic effect to osteosarcoma on account of synergistic contributions of ZnTCPP and FcCOOH. This FcCOOH-ZnTCPP system may pave a new way for precise and efficient tumor inhibition.

Cyclodextrin-based metal–organic framework nanoparticles as superior carriers for curcumin: Study of encapsulation mechanism, solubility, release kinetics, and antioxidative stability

In this paper, we propose a facile program of preparing nanoscale γ-cyclodextrin-based metal–organic frameworks (Nano-CD-MOFs) for the encapsulation of curcumin. Such Nano-CD-MOFs not only possess excellent mono-dispersity and crystalline structure, but also perform superior loading capacity. The results of N2 adsorption–desorption, XRD, DSC, and microtopography are utilized to confirm the presence status of encapsulated curcumin and further reveal the encapsulation mechanism of Nano-CD-MOFs. Curcumin-loaded Nano-CD-MOFs (Cur-Nano-CD-MOFs) dramatically increase curcumin solubility and a top-down uniform dispersion in the dissolution process. The perfect fitting of First-order and Korsmeyer-Peppas models suggests that the release performance of Nano-CD-MOFs is controlled by the loaded quantity of curcumin and related to Fickian diffusion. Moreover, the antioxidative stability of Cur-Nano-CD-MOFs is considerably enhanced even after 120 min of persistent ultraviolet irradiation. Therefore, we suggest that such Nano-CD-MOFs can be promoted as an advanced carrier for the delivery of curcumin or other nutraceuticals.

Fluorinated strategy of node structure of Zr-based MOF for construction of high-performance composite polymer electrolyte membranes

The dispersion and compatibility of metal–organic frameworks (MOFs) in polymeric matrices significantly influence the properties of composite membranes. However, the modification and functionalization of the node structures of MOFs to improve their dispersion in the polymeric matrix have been rarely studied. In this work, the node structures of UiO-66-NH2 frameworks were modified by the introduction of F species, and abundant Zr–F bonds and pore blocking effects were generated, which significantly affected the comprehensive performances of the composite membranes, including the dispersion, mechanical properties, proton conductivities, swelling ratios, and water uptake. Due to the good dispersion of the fluorinated MOF nanoparticles in the Nafion matrix, the composite membranes had high proton/methanol selectivity and low methanol permeability, which exhibited superior fuel cell performances in DMFCs (24.9–26.8 mW cm−2) to that of recast Nafion (20.4 mW cm−2). Notably, this was the first time that the node structures of MOF-based nanoparticles were fluorinated to improve their dispersion in a polymeric matrix, providing a simple strategy for developing high-performance composite membranes.

Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles.

Oral protein delivery is considered a cutting-edge technology to improve patients’ quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH2) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery. The UiO-68-NH2 nanocarrier with proper pore size achieved high insulin loading while protecting insulin from acid and enzymatic degradation. Through receptor-mediated transcellular pathway, the transferrin-coated nanoparticles realized efficient transport across the intestinal epithelium and controlled insulin release under physiological conditions, leading to a notable hypoglycemic effect and a high oral bioavailability of 29.6%. Our work demonstrates that functional metal-organic framework nanoparticles can protect proteins from the gastric environment and overcome the intestinal barrier, thus providing the possibility for oral biomacromolecule delivery.

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

In recent years, sonodynamic therapy (SDT) has been widely developed for cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of reactive oxygen species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for cancer therapy.

Metal-Organic-Framework-Decorated Carbon Nanofibers with Enhanced Gas Sensitivity When Incorporated into an Organic Semiconductor-Based Gas Sensor.

Because of their high porosity, metal-organic framework (MOF) materials have attracted much attention for use in gas-sensing applications. However, problems with the processability of MOFs for use in reliable gas-sensing electronics remain unsolved. Herein, combination of the strong gas-adsorbing properties of MOF nanomaterials and organic thin-film transistor-type chemical sensors is proposed and experimentally demonstrated. The hybrid blend system with inorganic MOF nanomaterials and organic semiconductors likely exhibits thermodynamic instability because of each phase's self-aggregation, which is difficult to settle without surface functionalization. We propose a novel method to produce an inorganic-organic hybrid sensor by introducing carbon nanofibers as a scaffold. We demonstrate that the carbon nanofibers perform dual functions: enabling the attachment of MOF nanoparticles at the fiber surface, which stabilizes the nanoparticle-embedded polymer layer, and maintaining reliable conductivity for improved gas-sensing performance. On the basis of our characterization of their nanomorphology and nanocrystal structure, the MOF nanoparticles and carbon nanofibers are shown to render a hybrid core-shell structure in the conjugated polymer matrix. This organic-inorganic hybrid system was incorporated into a field-effect transistor device to detect hazardous NO2 gas analytes, operating in real-time with high responsivity. The prototype chemical sensor holds enormous promise for other chemical sensors.

Tumor Microenvironment-Responsive Nanodrug for Clear-Cell Renal Cell Carcinoma Therapy via Triggering Waterfall-Like Cascade Ferroptosis.

The most common type of kidney tumor, clear-cell renal cell carcinoma (ccRCC) with relatively insidious development and easily metastatic characteristics is generally insensitive to cytotoxic chemotherapy. The abundant polyunsaturated fatty acids (PUFAs) content in advanced ccRCC allows it to be intrinsically vulnerable to ferroptosis-based therapeutic strategies. Nevertheless, the strategy to cause the "iron overload" by administration with iron-based nanomaterials has limited therapeutic efficacy. And the classic ferroptosis agonist (RSL3) with low specificity for tumors, short half-life in the blood, poor water solubility and deficient accumulation at the tumor site prevents its reliable application in vivo. In this study, iron-based metal-organic framework nanoparticles (MIL-101(Fe) NPs) delivered RSL3 to ccRCC tumors, and then released the iron ions and RSL3 accompanied by the degradation of MIL-101(Fe) NPs in the acidic tumor microenvironment. The MIL-101(Fe)@RSL3 as a pH-responsive nanodrug causes cellular iron overload and promotes the hydroxyl radical (•OH) generation by Fenton reaction to attack PUFAs, leading to the aberrant accumulation of lipid peroxides (L-OOH). Additionally, RSL3 directly inhibits glutathione peroxidase 4 (GPX4) to detoxify L-OOH, and ferrous ions further catalyze the irreversible conversion of highly reactive lipid alkoxyl radicals (L-O•) from L-OOH to triggering waterfall-like cascade ferroptosis. In contrast to the limited antitumor efficiency of free RSL3, MIL-101(Fe)@RSL3 with high encapsulation efficiency (88.7%) shows a significant ccRCC-specific antitumor effect and negligible side effects. Taken together, MIL-101(Fe)@RSL3 could aggravate ferroptosis and be expected to be a promising nanodrug for ccRCC systemic therapy due to the targeted delivery and responsive release of RSL3 and iron ions.

Biomimetic MOF Nanoparticles Delivery of C-Dot Nanozyme and CRISPR/Cas9 System for Site-Specific Treatment of Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of unknown etiology affecting the colon and rectum. Previous studies have found that reactive oxygen species (ROS) overproduction and transmembrane glycoprotein CD98 (encoded by SLC3A2) upregulation played important roles in the initiation and progression of UC. On the basis of this, a biomimetic pH-responsive metal organic framework (MOF) carrier was constructed to deliver carbon nanodot-SOD nanozyme and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) system for site-specific treatment of UC. In this system, carbon nanodots (C-dots) and CD98 CRISPR/Cas9 plasmid were successfully encapsulated into MOF carrier (ZIF-8 nanoparticles) by a one-pot approach (formed as CCZ), and then camouflaged with macrophage membrane (formed as CCZM). It was worth noting that the C-dot nanozyme showed excellent superoxide dismutase (SOD) enzymatic activity, which could scavenge ROS effectively. As expected, this biomimetic system exhibited pH-responsive, immune escape, and inflammation targeting capability simultaneously. In vitro experiments showed that ROS was significantly eliminated, and CD98 was downregulated by CCZM. In the dextran sulfate sodium salt (DSS)-induced UC model, administration of CCZM significantly ameliorated the inflammation symptoms of mice, including the colon length and pathological parameters such as epithelium integrity and inflammation infiltration. In addition, both in vitro and in vivo results demonstrated that biomimetic nanoparticles effectively reduced the expression of pro-inflammatory cytokines. Overall, this study would provide a promising approach for the precise treatment of UC.

Copper porphyrin metal-organic framework modified carbon paper for electrochemical sensing of glyphosate

Glyphosate (GLY), an exceedingly effective herbicide, has raised worries about the risks posing to the ecosystem and human health due to excessive exposure. An electrochemical sensor based on copper porphyrin metal organic framework and gold nanoparticles modified carbon paper (Cu-TCPP/AuNPs/CP) was developed for sensitive determination of GLY by differential pulse voltammetry (DPV). The Cu-TCPP has large surface area and excellent catalytic activity, increasing the copper sites to combine with GLY for selective determination and improving the sensitivity of the electrochemical sensor. Under optimized conditions, the constructed sensor has a linear range from 0.2 to 120 μmol L−1 with a detection limit of 0.03 μmol L−1 (S/N = 3). The sensor was applied to water, soybean, wheat and carrot with the recovery ranging from 97.5% to 110.7%. After two weeks storage at 4 °C, the peak current of the sensor remains 86.6% of the original value with negligible interference. This sensor has a great potential application in water, soil and other environmental samples.

Intervention with the Bone-Associated Tumor Vicious Cycle through Dual-Protein Therapeutics for Treatment of Skeletal-Related Events and Bone Metastases.

Bone metastasis is a common metastasis site such as lung cancer, prostate cancer, and other malignant tumors. The occurrence of bone metastases of lung cancer is often accompanied by bone loss, fracture, and other skeletal-related events (SREs) caused by tumor proliferation and osteoclast activation. Furthermore, along with the differentiation and maturation of osteoclasts in the bone microenvironment, it will further promote the occurrence and development of bone metastasis. Protein drugs are one of the most promising therapeutic pharmaceuticals, but in vivo delivery of protein therapeutics still confronts great challenges. In order to more effectively conquer bone metastases and alleviate SREs, herein, we constructed biomineralized metal-organic framework (MOF) nanoparticles carrying protein toxins with both bone-seeking and CD44-receptor-targeting abilities. More importantly, through combination with Receptor Activator of Nuclear Factor-κ B Ligand (RANKL) antibody, in vivo results demonstrated that these two protein agents not only enhanced the detraction effects of protein toxin agents as ribosome-inactivating protein (RIP) on bone metastatic tumor cells but also exhibited synergistic intervention of the crosstalk between bone cells and tumor cells and reduced SREs such as bone loss. Collectively, we expect that this strategy can provide an effective and safe option in regulating bone-tumor microenvironments to overcome bone metastasis and SREs.

Metal–Organic Framework‐Assisted Metal‐Ion Doping in All‐Inorganic Perovskite for Dual‐Mode Image Sensing Display

AbstractCrystal engineering based on defect passivation with metal ions doped into halide perovskites is of considerable interest for tailoring the photoelectric properties of perovskites. Herein, a simple and robust approach for doping metal ions into a thin all‐inorganic CsPbBr3 perovskite film by employing metal–organic framework nanoparticles is presented. Zeolitic imidazolate framework‐8 nanoparticles, which can adsorb water, are dispersed and embedded in a thin perovskite film. The particles self‐decompose at a certain humidity, releasing Zn2+ ions into nearby perovskite crystals. The Zn2+ ions efficiently passivate the undercoordinated defect sites of the defective perovskite crystals, resulting in environmentally stable and enhanced photoluminescence of the perovskite with a quantum yield of ≈14%, more than 24 times greater than that without nanoparticles. Further, a thin Zn‐doped CsPbBr3 film is employed to fabricate arrays of ultraviolet photodetectors, and ≈90% of the initial photocurrent is maintained over 15 d in RH 60%, facilitating the development of a dual‐mode image sensor using which programmed images are visualized based on both photocurrent and photoluminescence.

Folic Acid-Functionalized Metal-Organic Framework Nanoparticles as Drug Carriers Improved Bufalin Antitumor Activity Against Breast Cancer.

Bufalin (Buf), an active ingredient of the traditional Chinese medicine Chansu, is known to have anticancer effects for breast cancer. However, its poor solubility, high toxicity, and extensive side effects limit its use. Metal-organic frameworks (MOFs) are a class of promising drug delivery systems known for their high porosity. Here, we designed and constructed pH-sensitive and redox-responsive folic acid–modified MOFs as drug carriers of Buf (FA-MOF/Buf). Moreover, the anticancer activity of nanomedicines was also explored in vitro and in vivo. Compared to free Buf, the FA-MOF/Buf nanoparticles demonstrated improved water solubility and stability, higher intracellular uptake, and enhanced cytotoxicity in breast cancer cells in vitro. Furthermore, it displayed improved accumulation in the tumor site, enhanced anticancer activity, and reduced side effects in vivo. Our results demonstrated that FA-MOF could be developed as a potential delivery system for Buf to improve its antitumor activity for breast cancer treatment.

Single Nano-Sized Metal-Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy.

Theranostics is an emerging technique for cancer treatments due to its safety and high efficiency. However, the stability, efficiency, and convenience of preparation are the main challenges for developing theranostics. Here we describe a one-pot process for biocompatible metal–organic framework (MOF)-based theranostics. The ligand H2L designed for the MOF enables both red fluorescence emission and photodynamic therapy (PDT). The frame and regular channel structure of H2L-MOF empower the theranostics with good drug delivery performance, and the uniform and nano-sized particles facilitate the in vivo imaging/therapy applications. In vivo fluorescence imaging and in vitro chemo-photodynamic therapy were achieved with the MOF without any further modification. Our results reveal an effective strategy to achieve multifunctional theranostics by the synergistic action of the organic ligand, metal node, and channel structure of MOF nanoparticles.

Enzyme-Loaded Hemin/G-Quadruplex-Modified ZIF-90 Metal-Organic Framework Nanoparticles: Bioreactor Nanozymes for the Cascaded Oxidation of N-hydroxy-l-arginine and Sensing Applications.

Biocatalytic cascades are challenging to operate in homogeneous solution, where diffusional mass transport hinders efficient communication between the reactive components. There is great interest in developing devices to perform such transformations in confined environments, which increase the efficiency of the cascaded process by generating high local concentrations of the reactive species. Herein, a bioreactor-nanozyme assembly is introduced for the cascaded aerobic oxidation of N-hydroxy-l-arginine (NOHA) to citrulline in the presence of glucose. The reaction mimics a key step in the nitric oxide synthase oxidation of l-arginine in nature. The system consists of glucose oxidase (GOx)-loaded hemin/G-quadruplex (hemin/G4)-modified ZIF-90 metal-organic framework nanoparticles. The aerobic oxidation of glucose by GOx yields H2 O2 that fuels the hemin/G4-catalyzed oxidation of NOHA into citrulline. The process driven by the bioreactor-nanozyme system is ≈sixfold enhanced compared to the homogeneous mixture of the biocatalysts, due to its operation in the confined environment of the nanoparticles. Extension to a three-step cascade is then demonstrated using a bioreactor composed of β-galactosidase/GOx-loaded hemin/G4-modified ZIF-90 nanoparticles activating the cascaded oxidation of NOHA to citrulline, in the presence of lactose. Moreover, the bioreactor-nanozyme hybrid is applied as a functional optical sensor of glucose, using fluorescence or chemiluminescence as readout signals.

MiRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn(II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles.

An analytical platform for the selective miRNA-21-guided imaging of breast cancer cells and miRNA-221-guided imaging of ovarian cancer cells and the selective photodynamic therapy (PDT) of these cancer cells is introduced. The method is based on Zn(II)-protoporphyrin IX, Zn(II)-PPIX-loaded UiO-66 metal–organic framework nanoparticles, NMOFs, gated by two hairpins Hi/Hj through ligation of their phosphate residues to the vacant Zr4+-ions associated with the NMOFs. The hairpins are engineered to include the miRNA recognition sequence in the stem domain of Hi, and in the Hi and Hj, partial locked stem regions of G-quadruplex subunits. Intracellular phosphate-ions displace the hairpins, resulting in the release of the Zn(II)-PPIX and intracellular miRNAs open Hi, and this triggers the autonomous cross-opening of Hi and Hj. This activates the interhairpin hybridization chain reaction and leads to the assembly of highly fluorescent Zn(II)-PPIX-loaded G-quadruplex chains. The miRNA-guided fluorescent chains allow selective imaging of cancer cells. Moreover, PDT with visible light selectively kills cancer cells and tumor cells through the formation of toxic reactive oxygen species.

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone).

Iodine has been widely used as an effective disinfectant with broad-spectrum antimicrobial potency. However, the application of iodine in an antibacterial polymer remains challenging due to its volatile nature and poor solubility. Herein, iodine immobilized UiO-66-NH2 metal-organic framework (MOF) (UiO66@I2) with a high loading capacity was synthesized and used as an effective antibacterial additive for poly(ε-caprolactone) (PCL). An orthogonal design approach was used to achieve the optimal experiments’ conditions in iodine adsorption. UiO66@I2 nanoparticles were added to the PCL matrix under ultrasonic vibration and evaporated the solvent to get a polymer membrane. The composites were characterized by SEM, XRD, FTIR, and static contact angle analysis. UiO-66-NH2 nanoparticles have a high iodine loading capacity, up to 18 wt.%. The concentration of iodine is the most important factor in iodine adsorption. Adding 0.5 wt.% or 1.0 wt.% (equivalent iodine content) of UiO66@I2 to the PCL matrix had no influence on the structure of PCL but reduces the static water angle. The PCL composites showed strong antibacterial activities against Staphylococcus aureus and Escherichia coli. In contrast, the same content of free iodine/PCL composites had no antibacterial activity. The difference in the antibacterial performance was due to the different iodine contents in the polymer composites. It was found that MOF nanoparticles could retain most of the iodine during the sample preparation and storage, while there was few iodine left in the free iodine/PCL composites. This study offers a common and simple way to immobilize iodine and prepare antibacterial polymers with low antiseptic content that would reduce the influence of an additive on polymers’ physical properties.