Calcium Carbonate Nanoparticles Research Articles

Nanomotor-hydrogel Delivery System with Enhanced Antibacterial Performance for Wound Treatment.

In this study, we present a novel system consisting of nanomotors and a hydrogel. Calcium carbonate nanomotors are prepared using layer-by-layer self-assembly technology with calcium carbonate nanoparticles as the core and catalase (CAT) and polydopamine (PDA) as the shell. Calcium carbonate nanomotors were loaded into a Schiff base hydrogel to synthesize the CaCO3@NM-hydrogel system. A nanomotor is a device that works on the nanoscale to convert some form of energy to mechanical energy. The motion speed of the system in 5.0 mM H2O2 aqueous solution under near-infrared light (NIR) irradiation with a power density of 1.8 W/cm2 is 13.6 μm/s. The addition of CaCO3@NM further promotes gelation and improves the mechanical properties. The energy storage modulus increases to 4.0 × 103 Pa, which is 50 times higher. Schiff base hydrogels form dynamic reversible chemical bonds due to inter- and intramolecular hydrogen bonding. They also have good self-healing properties, as observed by measuring the energy storage modulus versus the loss modulus at 1 versus 10 kHz. The results show that the system significantly inhibited the growth of both Gram-positive bacteria, Staphylococcus aureus, and Gram-negative bacteria, Escherichia coli, after 48 h, with an inhibition rate of nearly 95%. These findings provide a basis for further research and potential applications of the system in wound dressings.

One-Step Phase Separation and Mineralization Fabrication of Membranes for Oily Wastewater Treatment.

Oily wastewater threatens the environment and the human health. Membrane technology offers a simple and efficient alternative to separating oil and water. However, complex membrane modifications are usually employed to optimize the separation performance. In this research, we develop an extremely simple one-step method to in situ calcium carbonate (CaCO3) nanoparticles onto a porous polyketone (PK) membrane via a nonsolvent induced phase separation (NIPS)-mineralization strategy. We utilized the unique chemical property of PK, which allows it to dissolve in a resorcinol aqueous solution. PK was mixed with tannic acid (TA) and calcium chloride (CaCl2) in a resorcinol aqueous solution to fabricate a casting solution. The activated membrane was cast and immersed into a sodium carbonate (Na2CO3) aqueous solution for taking the one-step NIPS-mineralization process. This proposed NIPS-mineralization mechanism comes to two conclusions: (i) the resulting membrane with comprehensive oleophobic properties and enhanced permeation flux for applications of oil/water separation with ultralow fouling and (ii) simplified the procedure to optimize the membrane performance using regular NIPS steps. The current work explores a one-step NIPS-mineralization technique that offers a novel approach to preparing membranes with highly efficient oil/water separation performance.

Highly graphitized coal tar pitch-derived porous carbon as high-performance lithium storage materials.

Because of its high specific capacity and superior rate performance, porous carbon is regarded as a potential anode material for lithium-ion batteries (LIBs). However, porous carbon materials with wide pore diameter distributions suffer from low structural stability and low electrical conductivity during the application process. During this study, the calcium carbonate nanoparticle template method is used to prepare coal tar pitch-derived porous carbon (CTP-X). The coal tar pitch-derived porous carbon has a well-developed macroporous-mesoporous-microporous hierarchical porous network structure, which provides abundant active sites for Li+ storage, significantly reduces polarization and charge transfer resistance, shortens the diffusion path and promotes the rapid transport of Li+. More specifically, the CTP-2 anode shows high charge capacity (496.9 mAh g-1 at 50 mA g-1), excellent rate performance (413.6 mAh g-1 even at 500 mA g-1), and high cycling stability (capacity retention rate of about 100% after 1,000 cycles at 2 A g-1). The clean and eco-friendly large-scale utilization of coal tar pitch will facilitate the development of high-performance anodes in the field of LIBs.

A novel approach to assessing the antioxidant and anti-diabetic potential of synthesized calcium carbonate nanoparticles using various extracts of Ailanthus altissima.

Calcium carbonate nanoparticles (CaCO3) have been found to exhibit unique properties that show their potential to be used in various therapies. Green synthesis of CaCO3 has been progressively gaining ac-ceptance due to its cost-effectiveness and energy-efficient nature. In the current study, different extracts of Ailanthus altissima were used to synthesize the calcium carbonate nanoparticles the synthesis and characterization of CCNPs were confirmed by using Fourier Transform Infra-Red spectroscopy, UV-Vis spectroscopy, and Scanning Electron Microscopy (SEM). The antioxidant activities (hydrogen peroxide, phosphomolydbenum, and ferric reducing) of calcium carbonate nanoparticles were affirmed by a good range of percentages of inhibition against free radical scavenging. The antidebate assays of CCNPs were observed by in-vitro and in silico approaches in a range at various concentrations while maximum inhibition occurred. In conclusion, the current study depicted that conjugated CaCO3 with A. altissima has a good potential to cure oxidative stress and Type II diabetes and could be used in the future as biogenic nanomedicine for the treatment of other metabolic diseases.

The change of physical properties of calcium carbonate nanomaterials cured soil in road substrates

The utilization of appropriate materials to enhance road subgrade’s physical characteristics is crucial for current transportation construction and maintenance. This study proposes a curing method that employs calcium carbonate nanomaterials to address the problem of soil displacement and settlement in roadway subgrades. A method was developed during the study to explore the optimal curing material ratio. Additionally, this study developed a method for testing and analyzing the mechanical properties of soils cured with nanomaterials, including measures of tensile stress, triaxial shear stress, and Moore’s damage envelope. The study demonstrated that the unconfined compressive strength of the soil treated with calcium carbonate nanomaterials was 0.40 MPa after 7 days of curing with a 6% doping of the curing agent. Increasing the doping to 18% resulted in a breaking load of the soil reaching 0.100 kN. Furthermore, the triaxial shear stress–strain curve of the soil exhibited a slope of 264.47 during the linear phase when the curing agent was dosed at 6%. The slope of the linear phase of the stress–strain curve for triaxial shear at 6% curing agent doping was found to be 264.47. The cured soil molar pack line exhibited an internal friction angle of 22.66 degrees at the same curing agent dosage. The displacement analysis of the replacement roadbed with cured soil revealed a maximum observed displacement of only 377 mm after filling the embankment using the study method. The experimental results provide support for the hypothesis of the study, which suggests that the application of calcium carbonate nanoparticles can significantly enhance the physical characteristics of road subgrade.

Preparation, Surface Modification, and Building Materials Applications of Calcium Carbonate Nanoparticles

Preparation, Surface Modification, and Building Materials Applications of Calcium Carbonate Nanoparticles

Preparation of microfibrillated cellulose by in situ and one step method using calcium hydroxide as swelling and grinding agent

Abstract Calcium hydroxide was used as a swelling agent and grinding aid to grind together with cellulose raw materials to prepare microfibrillated cellulose (MFC). Carbon dioxide was introduced to obtain MFC coated with calcium carbonate (CMFC). The effect of calcium hydroxide dosage on the fibrillation process of cellulose materials and the characteristics of MFCs and CMFCs were studied. Results show that when the dosage of calcium hydroxide was 5 % (based on cellulose materials), calcium hydroxide could be completely dissolved in water and had a swelling effect on cellulose materials. When the dosage reached 10 %, undissolved calcium hydroxide particles could serve as grinding media to assist in the fibrillation of cellulose materials. When the dosage exceeded 50 %, the auxiliary grinding effect of calcium hydroxide was more obvious. After accelerated carbonation, the generated calcium carbonate nanoparticles were coated on the surface of MFC, which increased its viscosity and decreased water retention value. The presence of calcium carbonate also facilitated the concentration, redispersion, and drying of MFC. The pretreatment, mechanical fibrillation, and accelerated carbonation were carried out in the same equipment without the need for heating or washing. Therefore, this study provides a in situ and one step method for the preparation of MFC.

Nanoarchitectonics of Bactericidal Coatings Based on CaCO3-Nanosilver Hybrids.

Antimicrobial coatings provide protection against microbes colonization on surfaces. This can prevent the stabilization and proliferation of microorganisms. The ever-increasing levels of microbial resistance to antimicrobials are urging the development of alternative types of compounds that are potent across broad spectra of microorganisms and target different pathways. This will help to slow down the development of resistance and ideally halt it. The development of composite antimicrobial coatings (CACs) that can host and protect various antimicrobial agents and release them on demand is an approach to address this urgent need. In this work, new CACs based on microsized hybrids of calcium carbonate (CaCO3) and silver nanoparticles (AgNPs) were designed using a drop-casting technique. Polyvinylpyrrolidone and mucin were used as additives. The CaCO3/AgNPs hybrids contributed to endowing colloidal stability to the AgNPs and controlling their release, thereby ensuring the antibacterial activity of the coatings. Moreover, the additives PVP and mucin served as a matrix to (i) control the distribution of the hybrids, (ii) ensure mechanical integrity, and (iii) prevent the undesired release of AgNPs. Scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) techniques were used to characterize the 15 μm thick CAC. The antibacterial activity was determined against Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa, three bacteria responsible for many healthcare infections. Antibacterial performance of the hybrids was demonstrated at concentrations between 15 and 30 μg/cm2. Unloaded CaCO3 also presented bactericidal properties against MRSA. In vitro cytotoxicity tests demonstrated that the hybrids at bactericidal concentrations did not affect human dermal fibroblasts and human mesenchymal stem cell viability. In conclusion, this work presents a simple approach for the design and testing of advanced multicomponent and functional antimicrobial coatings that can protect active agents and release them on demand.

Amorphous CaCO3-bioreactor for tumor microenvironment regulation to reinforce tumor chemoimmunotherapy

Developing efficient nanomedicines to modulate the immunosuppressive tumor microenvironment (TME) is a highly sought-after method for improving the adverse clinical outcomes of immunotherapy. In this study, we designed a novel tumor immune stimulatory nanomedicine to regulate the immunosuppressive TME in multiple directions. This nanomedicine is liposome-modified amorphous calcium carbonate (ACC) nanoparticles (referred to as CEL/ACC-LP NPs) loaded with chemotherapeutic medication celastrol (CEL). CEL/ACC-LP NPs explosively release calcium ions (Ca2+) and CEL in the tumor acidic microenvironment, and rapidly deplete H+ to alleviate the tumor acidic microenvironment, exhibiting intrinsic immune regulatory activity in synergistic tumor chemoimmunotherapy. CEL induces reactive oxygen species (ROS) to promote Ca2+ influx, exacerbating cellular Ca2+ overload. In addition, CEL/ACC-LP NPs can cause unique immunogenic cell death (ICD) effects. Therefore, the multi-directional regulation of tumor cells through simple nano preparation will offer a potent approach to improve the efficacy of chemoimmunotherapy.

The Compressive Strength of Unsaturated polyester reinforced by natural and synthetic Calcium Carbonate

A modifications on the ultimate compression strength of unsaturated polyester (UPE) carrying out, by adding nano Chicken eggshells fibers (E.S) as a natural source of calcium carbonate or synthetic nano calcium carbonate particles (CaCO3) in different weight percentages ranging from (1-5%). The ratio (1% eggshell fibers) and (3% CaCO3) are the best weight ratios that selected according to ultimate compressive strength of Unsaturated Polyester composites. Ultamite compressive strength was improved from (73.84 N/mm2) for UPE to (85.54 N/mm2) for (UPE/1% E.S) composite and to higher value (87.88 N/mm2) for (UPE/3%CaCO3) composite. The partictes with nano-sized of titanium dioxide (TiO2) was used to reinforce the two best composites, to get more improvement in there ultamite compressive strength to reach to (94.27 N/mm2) for (UPE/1%E.S) and to (100.18 N/mm2) for (UPE/3%CaCO3) composites.

Recent Developments on the Effects of Micro- and Nano-Limestone on the Hydration Process, Products, and Kinetics of Cement.

Limestone is commonly used in cement concrete due to its unique nature and type. It has physical effects (nucleation effect and dilution effect) and chemical effects on the hydration process of cement. This paper reviews the effects of three representative limestone materials on the hydration process, hydration products, and hydration kinetics. In the hydration process, the reaction was delayed by limestone powder with a particle size larger than 20 μm and calcium carbonate whiskers due to their dilutive effect. On the other hand, limestone powder with a particle size smaller than 20 m and calcium carbonate nanoparticles facilitated the reaction through nucleation and chemical effects. Limestone has a similar effect on hydration products, promoting the production of C-S-H through nucleation. The mechanism of action for this nucleation effect depends on the differences in crystalline form and particle size of the three types of micro- and nano-calcium. Chemical effects impact the amount of AFt produced, with the generation of new products being the main reaction influenced by the limestone admixture.

Synthesis of graphene mesosponge using CaO nanoparticles formed from CaCO3

While graphene mesosponge (GMS) is a new type of mesoporous material with the potential for a variety of applications, its synthesis process requires costly templates such as Al2O3 and MgO nanoparticles. In this study, we present a new synthesis method for GMS, which achieves a high specific surface area of 1720 m2 g1 by employing calcium oxide (CaO) nanoparticles as templates. The CaO nanoparticles with an approximate diameter of 86 nm are formed through the thermal decomposition of calcium carbonate nanoparticles. However, the calcium carbonate nanoparticles contain a small amount of Mg (2 wt %), and the thermal decomposition process also yields impurities, including Mg. When the CaO nanoparticles, including the Mg-based impurities, are subjected to chemical vapor deposition, the CaO surface can be coated with a thin carbon layer, primarily consisting of single-layer graphene through the specific catalysis of the CaO surface in facilitating the CH4-to-C conversion reactions. However, at the same time, the presence of Mg-based impurities leads to the formation of low-crystalline carbons, which have a detrimental effect on the subsequent high-temperature annealing at 1800 °C, following the template removal process, resulting in an excessive number of edge sits in the GMS. We have found that the harmful low-crystalline carbons can be eliminated through heat treatment in air at 350 °C. By adopting such a removal process, high-quality GMS with a minimal number of edge sites can be produced.

Self-desiccation behavior of nano-cemented tailings backfill plug: Insights from thermo-mechanical-chemical column experiments

This paper examines the influence of various factors, including the addition of nano-calcium carbonate particles (chemical processes, C) to CPBs, non-isothermal field curing temperatures (thermal factor, T), and field vertical curing stress (mechanical factor, M), on the self-desiccation capacity of CPB plugs. The assessment of self-desiccation involves the determination of pore water pressure (PWP) and volumetric water content (VWC) in the examined CPBs. Thermo-mechanical-chemical (TMC) column experiments were conducted to investigate the interaction among these factors and their collective impact on the evolution of PWP and VWC within the CPB plug. The findings underscore that each factor, both individually and in combination, significantly affects the magnitude and progression of self-desiccation in CPB plugs. Notably, the factors of elevated field temperature and the introduction of nano-calcium carbonate (NC) to the CPB exert the most substantial influence on the extent and enhancement of self-desiccation, whereas the impact of field curing stress in isolation is comparatively much weaker. The integration of nano-calcium carbonate, especially under non-isothermal conditions and concurrent field stress, emerges as a key contributor to enhanced PWP and VWC dissipation rates. The role of non-isothermal field curing temperature is underscored as a significant contributing factor in the self-desiccation of CPB plugs. The results presented in this paper will contribute to a more cost-effective design of CPB plugs and the improved optimization of CPB mixtures with nano-calcium carbonate particles.

Cracking resistance of crumb rubber modified green asphalt mixtures, using calcium carbonate nanoparticles and two by-product wax-based warm mix additives

Common procedures to incorporate the recycled crumb rubber (CR) in asphalt binders take a long time and use a high-temperature heating process, which makes these rubberized mixtures even more expensive and environment-unfriendly than conventional mixtures. In trying to make a cheaper and greener asphalt mixture, in this paper, the CR incorporation heating process and its duration were lowered (140–150°C in 15 minutes), and the effect of these changes was studied on the pavement's tensile/shear cracking resistance. Because the main disadvantage of using CR is the increase of viscosity, two by-products, slack wax (SW) and polypropylene wax (PPW) were used to correct the viscosity; also their effect on fracture toughness (Keff) and fracture energy (Gf) was assessed. As results showed that the following process decreases the cracking resistance, calcium carbonate nanoparticles (CCN) in different contents were added. Results show that adding 15% CR reduces Keff and Gf by about 18 and 16%, respectively. Adding the SW and PPW further reduces them by about 8 and 16%, respectively. In this condition, adding CCN in optimal content (about 5%) compensates for these reductions. Although these greener asphalts have the same cracking resistance as the control mixture, the environmental and cost-effectiveness analysis shows the developed materials are greener and cheaper.

Application of new tetra-cationic imidazolium ionic liquids for capture and conversion of CO2 to amphiphilic calcium carbonate nanoparticles as a green additive in water based drilling fluids

Conversion and capture of carbon pollutants based on carbon dioxide to valuable green oil-field chemicals are target all over the world for controlling the global warming. The present article used new room temperature amphiphilic imidazolium ionic liquids with superior surface activity in the aqueous solutions to convert carbon dioxide gas to superior amphiphilic calcium carbonate nanoparticles. In this respect, tetra-cationic ionic liquids 2-(4-dodecyldimethylamino) phenyl)-1,3-bis (3-dodecyldimethylammnonio) propyl) bromide-1-H-imidazol-3-ium acetate and 2-(4-hexyldimethylamino) phenyl)-1,3-bis(3-hexcyldimethylammnonio) propyl) bromide-1 H-imidazol-3-ium acetate were prepared. Their chemical structures, thermal as well as their carbon dioxide absorption/ desorption characteristics were evaluated. They were used as solvent and capping agent to synthesize calcium carbonate nanoparticles with controlled crystalline lattice, sizes, thermal properties and spherical surface morphologies. The prepared calcium carbonate nanoparticles were used as additives for the commercial water based drilling mud to improve their filter lose and rheology. The data confirm that the lower concentrations of 2-(4-dodecyldimethylamino) phenyl)-1,3-bis (3-dodecyldimethylammnonio) propyl) bromide-1-H-imidazol-3-ium acetate achieved lower seawater filter lose and improved viscosities.

An experimental review on enhancing the low and high-velocity impact resistance of NFCs through nanoparticle reinforcement

Nanoparticles are widely used in biocomposite materials due to their ability to improve the mechanical properties of composites. This comprehensive review analyzes the use of nanoparticles to enhance the experimental low and high-velocity impact resistance of natural fiber composites. Various nanoparticles like carbon nanofibers, carbon nanotubes, boron nitride, zinc oxide, and titanium dioxide were investigated as reinforcements at different loading levels. The addition of nano-ZrO2 alone or with graphene oxide yielded the highest impact resistance and interlaminar shear strength of basalt fiber/epoxy composites. Cloisite 20A clay improved the mechanical properties of an epoxy matrix. Carbon/epoxy laminates showed improved maximum impact force, energy absorption, and displacement with 2wt% carbon nanofibers loading. Nanoparticles were found to enhance moisture and temperature resistance by strengthening the fiber–matrix interface. The literature demonstrated that small amounts of well-dispersed nanoparticles can meaningfully improve natural fiber composites’ impact resistance, strength, stiffness, toughness, and energy absorption through mechanisms like crack arresting and bridging. Hybrid carbon-basalt fibers and calcium carbonate nanoparticles also enhanced composite performance. Balancing the nanoparticle loading is crucial to prevent agglomeration effects. Future studies on their toxicity and environmental impacts would be needed for widespread commercial applications of Biocomposites.

Molecular dynamics simulation and experimental study on the mechanical properties of PET nanocomposites filled with CaCO3, SiO2, and POE-g-GMA

Abstract This work investigated the mechanical properties of polyethylene terephthalate (PET) reinforced with calcium carbonate (CaCO3) and silica (SiO2) nanoparticles, respectively, and the improvement in toughness of the ternary system with the incorporation of graft-modified ethylene-1-octene copolymer (POE-g-GMA). PET nanocomposites were prepared by melt blending extrusion and injection molding. Molecular dynamics (MD) simulation was employed to construct models for binary system filled with nanoparticles and ternary system with the additional inclusion of POE-g-GMA elastomers. The results of mechanical property tests and MD simulation revealed that the binary system exhibited increased elastic modulus and tensile strength, mainly attributed to the effective reinforcement of rigid nanoparticles and the surface adsorption between nanoparticles and the PET matrix enhanced the interfacial interactions. CaCO3 indicated a more pronounced reinforcing effect, possibly due to the higher crystallinity of its composites. The incorporation of POE-g-GMA resulted in a significant improvement in impact strength and the elongation at break of PET nanocomposites. This enhancement in toughness is attributed to the elastomer’s ability to absorb a substantial amount of impact energy, while the elastic modulus is higher than that of pure PET.

Reversible Deacidification and Preventive Conservation of Paper-Based Cultural Relics by Mineralized Bacterial Cellulose.

Paper-based cultural relics experience irreversible aging and deterioration during long-term preservation. The most common process of paper degradation is the acid-catalyzed hydrolysis of cellulose. Nowadays, deacidification has been considered as a practical way to protect acidified literature; however, two important criteria of minimal intervention and reversibility should be considered. Inspired by the superior properties of bacterial cellulose (BC) and its structural similarity to paper, herein, the mineralized BC membranes are applied to deacidification and conservation of paper-based materials for the first time. Based on the enzyme-induced mineralization process, the homogeneous and high-loaded calcifications of hydroxyapatite (HAP) and calcium carbonate (CaCO3) nanoparticles onto the nanofibers of BC networks have been achieved, respectively. The size, morphology, structure of minerals, as well as the alkalinity and alkali reserve of BC membranes are well controlled by regulating enzyme concentration and mineralization time. Compared with HAP/CaCO3-immersed method, HAP/CaCO3-BC membranes show more efficient and sustained deacidification performance on paper. The weak alkalinity of mineralized BC membranes avoids the negative effect of alkali on paper, and the high alkali reserve implies a good sustained-release effect of alkali to neutralize the future generated acid. The multiscale nanochannels of the BC membrane provide ion exchange and acid/alkali neutralization channels between paper and the BC membrane, and the final pH of protected paper can be well stabilized in a certain range. Most importantly, this BC-deacidified method is reversible since the BC membrane can be removed without causing any damage to paper and the original structure and fiber morphology of paper are well preserved. In addition, the mineralized BC membrane provides excellent flame-retardant performance on paper thanks to its unique organic-inorganic composite structure. All of these advantages of the mineralized BC membrane indicate its potential use as an effective protection material for the reversible deacidification and preventive conservation of paper-based cultural relics.

Nano‐Calcium Carbonate with Core–Shell Structure was Prepared by Dopamine Chelation Using Pluronic F‐127 as Template

AbstractHerein, a new template carbonization method is used to prepare calcite‐type nano‐calcium carbonate (CaCO3) with a core–shell structure using calcium hydroxide as a solute and Pluronic F‐127 as a templating and pore‐forming agent. Dopamine hydrochloride is added to control the size of calcium hydroxide particles. The morphology, particle size, and crystal type of CaCO3 are characterized via transmission electron microscopy, X‐ray diffraction, nanoparticle size, and zeta potentiometer. The creation of core–shell calcium carbonate nanoparticles is examined in relation to reaction circumstances (i.e., additive sequence, additive amount, and additive mixing time), carbonization temperature, liquid flow rate, and templates with varying chain lengths. Furthermore, a discussion is held regarding the formation mechanism of spherical core–shell calcium carbonate that is created using the innovative template carbonization method. The results show that the order, amount, liquid flow rate, and template type of additives have a significant effect on the crystal shape of calcium carbonate nanoparticles. The mixing time of additives has a significant effect on the particle size of calcium carbonate nanoparticles. Interestingly, the thickness of the shell depends on the carbonization temperature, and too slow or too fast flow rate will lead to the formation of cyclic calcium carbonate nanoparticles.

Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment.

Regarded as one of the hallmarks of tumorigenesis and tumor progression, the evasion of apoptotic cell death would also account for treatment resistance or failure during cancer therapy. In this study, a Ca2+/Cu2+ dual-ion "nano trap" to effectively avoid cell apoptosis evasion by synchronously inducing paraptosis together with apoptosis was successfully designed and fabricated for breast cancer treatment. In brief, disulfiram (DSF)-loaded amorphous calcium carbonate nanoparticles (NPs) were fabricated via a gas diffusion method. Further on, the Cu2+-tannic acid metal phenolic network was embedded onto the NPs surface by self-assembling, followed by mDSPE-PEG/lipid capping to form the DSF-loaded Ca2+/Cu2+ dual-ions "nano trap". The as-prepared nanotrap would undergo acid-triggered biodegradation upon being endocytosed by tumor cells within the lysosome for Ca2+, Cu2+, and DSF releasing simultaneously. The released Ca2+ could cause mitochondrial calcium overload and lead to hydrogen peroxide (H2O2) overexpression. Meanwhile, Ca2+/reactive oxygen species-associated mitochondrial dysfunction would lead to paraptosis cell death. Most importantly, cell paraptosis could be further induced and strengthened by the toxic dithiocarbamate (DTC)-copper complexes formed by the Cu2+ combined with the DTC, the metabolic products of DSF. Additionally, the released Cu2+ will be reduced by intracellular glutathione to generate Cu+, which can catalyze the H2O2 to produce a toxic hydroxyl radical by a Cu+-mediated Fenton-like reaction for inducing cell apoptosis. Both in vitro cellular assays and in vivo antitumor evaluations confirmed the cancer therapeutic efficiency by the dual ion nano trap. This study can broaden the cognition scope of dual-ion-mediated paraptosis together with apoptosis via a multifunctional nanoplatform.