Nanomaterials For Photothermal Therapy Research Articles

Construction of pH/NIR responsive silver sulfide metal-organic frameworks for photothermal/chemotherapy synergistic treatment of tumor

In recent years, photothermal therapy (PTT), a new type of therapy, has been gradually recognized as a rapidly developing technology, and many nanomaterials have been applied to PTT. One of the representative nanomaterials in this field is nanoscale silver sulfide with rising significance in biomedicine like cell imaging. However, there are not much researches on the use of silver sulfide nanomaterials in photothermal therapy. Thus, a novel core-shell nanostructure was fabricated by encapsulating a hollow silver sulfide (HAg2S) core with a zeolite imidazole acid skeleton (ZIF-8), which is a representative metal-organic framework (MOF) crystal, for the purpose of carrying doxorubicin hydrochloride (DOX). The as-prepared HAg2S/ZIF-8 core-shell nanostructure can be targeted by hyaluronic acid (HA) molecules that are able to bind with CD44 receptors over-expressed on a variety of cancer cells, thereby implementing synergistic photothermal effect and chemotherapeutic effect in near-infrared (NIR) region in association with multiple responses to pH, HA, and NIR as well as DOX release. In summary, the present approach could help to inject fresh vitality into the future cancer cure.

Temperature-Sensitive Polymer-Driven Nanomotors for Enhanced Tumor Penetration and Photothermal Therapy.

Self-propelled nanomotors possess strong propulsion and penetration abilities, which can increase the efficiency of cellular uptake of nanoparticles and enhance their cytotoxicity against tumor cells, opening a new path for treating major diseases. In this study, the concept of driving nanomotors by alternately stretching and contracting a temperature-sensitive polymer (TS-P) chain is proposed. The TS-Ps are successfully linked to one side of Cu2-xSe@Au (CS@Au) nanoparticles to form a Janus structure, which is designated as Cu2-xSe@Au-polymer (CS@Au-P) nanomotors. Under near-infrared (NIR) light irradiation, Cu2-xSe nanoparticles generate photothermal effects that change the system temperature, triggering the alternation of the TS-P structure to generate a mechanical force that propels the motion of CS@Au-P nanomotors. The nanomotor significantly improved the cellular uptake of nanoparticles and enhanced their penetration and accumulation in tumor. Furthermore, the exceptional photothermal conversion efficiency of CS@Au-P nanomotors suggests their potential as nanomaterials for photothermal therapy (PTT). The prepared material exhibited good biocompatibility and anti-tumor effects both in vivo and in vitro, providing new research insights into the design and application of nanomotors in tumor therapy.

Carbon-based Nanomaterials in Photothermal Therapy Guided by Photoacoustic Imaging: State of Knowledge and Recent Advances.

Carbon-based nanomaterials (CBNM)have been widely used in various fields due to their excellent physicochemical properties. In particular, in the area of tumor diagnosis and treatment, researchers have frequently reported them for their potential fluorescence, photoacoustic (PA), and ultrasound imaging performance, as well as their photothermal, photodynamic, sonodynamic, and other therapeutic properties. As the functions of CBNM are increasingly developed, their excellent imaging properties and superior tumor treatment effects make them extremely promising theranostic agents. This review aims to integrate the considered and researched information in a specific field of this research topic and systematically present, summarize, and comment on the efforts made by authoritative scholars. In this review, we summarized the work exploring carbon-based materials in the field of tumor imaging and therapy, focusing on PA imaging-guided photothermal therapy (PTT) and discussing their imaging and therapeutic mechanisms and developments. Finally, the current challenges and potential opportunities of carbon-based materials for PA imaging-guided PTT are presented, and issues that researchers should be aware of when studying CBNM are provided.

The Applications of Nanomaterials in Phototherapy Against Cancer

Since nowadays cancers have caused a high death rate among human, it is quite important to find some new therapies against cancer. Phototherapy is a promising therapy against the cancer due to its better effect than other traditional methods, but still needs some improvements. With the combinations of the nanomaterials, some of the disadvantages of phototherapy have been solved, because of the properties of nanomaterials such as low toxicity, good biocompatibility, high selectivity and so on. However, some shortcomings still exist. This paper will be first divided into two parts to introduce the applications of nanomaterials in photothermal therapy (PTT) and photodynamic therapy (PDT) and their current problems and solutions, respectively. Then the effects brought by the cooperation of PTT and PDT are mentioned. The final part is about the directions of future developments of them. With the development of the nanotechnology, the nanomaterials can overcome more and more weaknesses in the phototherapy and get better effects.

Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects.

Resistance to antimicrobial agents has been alarming in recent years and poses a huge public health threat globally according to the WHO. The increase in morbidity and mortality resulting from microbial infections has been attributed to the emergence of multidrug-resistant microbes. Associated with the increase in multidrug resistance is the lack of new and effective antimicrobials. This has led to global initiatives to identify novel and more effective antimicrobial agents in addition to discovering novel and effective drug delivery and targeting methods. The use of nanoparticles as novel biomaterials to fully achieve this feat is currently gaining global attention. Nanoparticles could become an indispensable viable therapeutic option for treating drug-resistant infections. Of all the nanoparticles, the metals and metal oxide nanoparticles appear to offer the most promise and have attracted tremendous interest from many researchers. Moreover, the use of nanomaterials in photothermal therapy has received considerable attention over the years. This review provides current insight on antimicrobial resistance as well as the mechanisms of nanoparticle antibacterial activity. It offers an in-depth review of all the recent findings in the use of nanomaterials as agents against multi-resistant pathogenic bacteria. Also, nanomaterials that can respond to light stimuli (photothermal therapy) to kill microbes and facilitate enhanced drug delivery and release are discussed. Moreover, the synergistic interactions of nanoparticles with antibiotics and other nanomaterials, microbial adaptation strategies to nanoparticles, current challenges, and future prospects were extensively discussed.Graphic abstract

Recent advances in the photothermal applications of two-dimensional nanomaterials: photothermal therapy and beyond

The photothermal applications of 2D nanomaterials in photothermal therapy, water evaporation, thermochemical reactions, light-driven actuators, photothermal electrodes, energy storage, wearable heaters and bacterial inhibition.

Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles.

The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.

Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy.

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment.

BackgroundCancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions.MethodsIn this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS2QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy.ResultsThis review found much evidence for the use of inorganic nanoparticles for PTT-based combinational cancer therapy.ConclusionUnder synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.

Advances in nanomaterials for use in photothermal and photodynamic therapeutics (Review).

Nanomaterials play crucial roles in the diagnosis and treatment of diseases. Photothermal and photodynamic therapy, as two minimally invasive therapeutic methods, have promising potential in the diagnosis and prevention of cancer. Recently, many photothermal materials (such as noble metal material, transition metal sulfur oxides, carbon material and upconversion nanomaterial) and photodynamic materials (such as phthalein cyanogen, porphyrins and other dye molecules) have been applied in photothermal therapy (PTT) and photodynamic therapy (PDT). Moreover, as nanomaterials have suitable biocompatibility, these materials have been applied in cancer therapy. In the present review, we summarized the effects of different material types, synthesis methods, material morphologies and surface modifications on the outcomes of cancer therapy. The application of nanomaterials in PTT and PDT was introduced and the advantages and disadvantages of PTT and PDT in the prevention of cancer were discussed. Finally, we discussed the application of nanomaterials in the combination of PTT and PDT in cancer treatment.

Synthesis and Applications of Two-Dimensional Transition Metal Sulfide Nanomaterials in Photothermal Therapy

Synthesis and Applications of Two-Dimensional Transition Metal Sulfide Nanomaterials in Photothermal Therapy

Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite

Herein we present a successful strategy for enhancement of photothermal efficiency of hydroxyapatite (HAP) by its conjugation with carbon nanotubes (CNTs) and graphene nanosheets (GR). Owing to excellent biocompatibility with human body and its non-toxicity, implementation of HAP based nanomaterials in photothermal therapy (PTT) provides non-replaceable benefits over PTE agents. Therefore, in this report, it has been experimentally exploited that the photothermal effect (PTE) of HAP has significantly improved by its assembly with CNTs and GR. It is found that the type of carbon nanomaterial used to conjugate with HAP has influence on its PTE in such a way that the photothermal efficiency of GR-HAP was higher than CNTs-COOH-HAP under exposure to 980nm near-infrared (NIR) laser. The temperature attained by aqueous dispersions of both CNTs-COOH-HAP and GR-HAP after illuminating to NIR radiations for 7min was found to be above 50°C, which is beyond the temperature tolerance of cancer cells. So that the rise in temperature shown by both CNTs-COOH-HAP and GR-HAP is enough to induce the death of tumoral or cancerous cells. Overall, this approach in modality of HAP with CNTs and GR provide a great potential for development of future nontoxic PTE agents.

Tellurium platinate nanowires for photothermal therapy of cancer cells.

Among the most celebrated modes of cancer treatment, photothermal therapy has been the most promising tool over the past few years. In spite of the introduction of many novel nanomaterials for photothermal therapy, there is still plenty of room for exploration of naïve materials. We have explored the photothermal properties of metal chalcogenides, namely tellurium platinate nanowires (TePt NWrs), in this work. Upon irradiation with a laser (Ti:sapphire laser, 808 nm) the temperature of the aqueous suspension of TePt NWrs was found to increase to ∼62 °C from room temperature at optimum concentrations. This was due to the stability and high photothermal transduction efficiency of nanorods (NRs) i.e.∼47%. The power to ablate tumor cells was studied using A549 cells and tumor grafted experimental mice models. After an initial exposure for 10 min (808 nm laser at 1 W cm-2), the cells were killed mainly by the process of apoptosis as confirmed by a flow cytometry assisted cell sorting system (FACS; PI-FITC-Annexin V staining). Tumor growth was significantly reduced after photothermal therapy via a combination of TePt NRs and laser, thus proving the importance of this new nanomaterial for cancer photothermal therapy. The current approach has introduced a highly potential photothermal therapy method for applications in the medical world in the near future.

Applied Research of Nanomaterials in Photo-thermal Therapy

In the applied research of nanomaterials in photo-thermal therapy and based on the understanding of the principle of photo-thermal therapy and its medical equipment, this paper analyzes nanomaterials used for photo-thermal therapy, establishes model by the use of comprehensive evaluation method and selects nano-materials that are suiTable for photo-thermal therapy, namely, carbon nanomaterials and precious metal nano-materials. In addition, this paper analyzes the importance of human surgical health by the use of photo-thermal therapy and gives considerations from three aspects, that is, the surgical equipment health, the operating room hygiene and the medical health. This paper also establishes a mathematical model through correlation analysis and credibility analysis, thus emphasizing the necessity of surgical health.