Nanoscale Materials Research Articles

Novel probe with iRGD integrated graphene oxide nanoparticles and labeled with 131I for detection of thyroid papillary carcinoma cells

Abstract Integrating multiple targets and hence bio-distribution effectively for papillary thyroid carcinoma (PTC) treatment remains a significant challenge, which can be addressed by using suitable nano-scale materials. Herein, iRGD-modified graphene oxide (GO) loaded 131I are developed for the specific treatment of PTC strengthened integrin targeting. Fine structural characteristics of GO and GO-iRGDs were characterized by fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEC), Raman spectrum and X-ray photoelectron spectroscopy (XPS). The results showed that there were characteristic peaks and chemical bonds on GO and GO-iRGDs by FT-IR, the D-peak and G-peak of GO disappeared by Raman spectrum and C-N bond with iRGD of GO-iRGDs were strong by XPS. These 131I-GO-iRGDs and 131I-GOs were taken up by PTC cell (TPC-1, BCPAP, and IHH-4) through endocytosis after 48 h and 72 h in cell uptake test, especially the uptake rate of 131I-GO50-iRGD was the highest. The CCK-8 cytotoxicity test of 131I-GO-iRGDs and 131I-GOs showed that these nanoparticles toxicity were higher than that of Na131I and finally promoted PTC death. In vitro data verified the targeting mechanism of GO and 131I for PTC cell line is based on the relevant advantages of binding cell, followed by iRGD-endowed cell surface transport. The tailored design of GO-iRGDs validates a promising paradigm for radioisotope (131-iodine) delivery to combat PTC resistance and metastasis resulting from poor target access for effective combination therapy.

Bio-mediated synthesis of nanoparticles: A new paradigm for environmental sustainability

The synthesis of nanoscale metals and non-metals is an intriguing subject, and the green synthesis of nanoparticles (NPs) is increasingly utilized across various sectors, including environmental science, agriculture, engineering, and food processing. Traditionally, the production of nanoscale materials relies heavily on physical and chemical processes, which can lead to significant challenges such as high energy consumption and environmental contamination. Poor management of agricultural and industrial waste contributes to greenhouse gas emissions, exacerbates climate change and disrupts ecosystems. Conversely, green nanotechnology offers a safer alternative by leveraging biological materials, that inherently provide capping and reducing agents. This approach is not only more cost-effective but also results in lower pollution levels, thereby enhancing environmental safety. Green synthesis involves the reduction of metallic and non-metallic atoms using plant extracts, microorganisms, and agricultural waste instead of conventional harmful substances. The bioactive compounds, including flavonoids, alkaloids, tannins, and saponins, play a critical role in the bioreduction of metals and the production of nanoparticles. There has been the increasing interest in utilizing these biological sources for green nanoparticle production over the past decade from their potential to serve as economical and environmentally friendly alternatives. Overall, green nanotechnology demonstrates its potential to revolutionize industries and pave the way for a more sustainable and resilient future.

Lattice Anisotropy-Driven Reduction of Phonon Velocities in Black Phosphorus.

Phonon dynamics and transport determine how heat is utilized and dissipated in materials. In 2D systems for optoelectronics and thermoelectrics, the impact of nanoscale material structure on phonon propagation is central to controlling thermal conduction. Here, we directly observe in-plane coherent acoustic phonon propagation in black phosphorus (BP) using ultrafast electron microscopy. We identify a significant reduction of the group velocities in directions intermediate to the armchair and zigzag lattice directions. Using a machine learning-based model with an >8000 atom supercell, we find that this slowing results from the mixing of in-plane transverse and longitudinal acoustic phonons and is independent of broken symmetries of edge reconstructions. This work demonstrates how coherent phonon transport is sensitive to propagation direction in the lattice plane.

From Traditional Nanoparticles to Cluster-Triggered Emission Polymers for the Generation of Smart Nanotheranostics in Cancer Treatment

Nanotheranostics integrates diagnostic and therapeutic functionalities using nanoscale materials, advancing personalized medicine by enhancing treatment precision and reducing adverse effects. Key materials for nanotheranostics include metallic nanoparticles, quantum dots, carbon dots, lipid nanoparticles and polymer-based nanocarriers, each offering unique benefits alongside specific challenges. Polymer-based nanocarriers, including hybrid and superparamagnetic nanoparticles, improve stability and functionality but are complex to manufacture. Polymeric nanoparticles with aggregation-induced emission (AIE) present promising theranostic potential for cancer detection and treatment. However, challenges such as translating the AIE concept to living systems, addressing toxicity concerns, overcoming deep-tissue imaging limitations, or ensuring biocompatibility remain to be resolved. Recently, cluster-triggered emission (CTE) polymers have emerged as innovative materials in nanotheranostics, offering enhanced fluorescence and biocompatibility. These polymers exhibit increased fluorescence intensity upon aggregation, making them highly sensitive for imaging and therapeutic applications. CTE nanoparticles, crafted from biodegradable polymers, represent a safer alternative to traditional nanotheranostics that rely on embedding conventional fluorophores or metal-based agents. This advancement significantly reduces potential toxicity while enhancing biocompatibility. The intrinsic fluorescence allows real-time monitoring of drug distribution and activity, optimizing therapeutic efficacy. Despite their potential, these systems face challenges such as maintaining stability under physiological conditions and addressing the need for comprehensive safety and efficacy studies to meet clinical and regulatory standards. Nevertheless, their unique properties position CTE nanoparticles as promising candidates for advancing theranostic strategies in personalized medicine, bridging diagnostic and therapeutic functionalities in innovative ways.

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research.

Nanosafety assessment, which seeks to evaluate the risks from exposure to nanoscale materials, spans materials synthesis and characterisation, exposure science, toxicology, and computational approaches, resulting in complex experimental workflows and diverse data types. Managing the data flows, with a focus on provenance (who generated the data and for what purpose) and quality (how was the data generated, using which protocol with which controls), as part of good research output management, is necessary to maximise the reuse potential and value of the data. Instance maps have been developed and evolved to visualise experimental nanosafety workflows and to bridge the gap between the theoretical principles of FAIR (Findable, Accessible, Interoperable and Re-usable) data and the everyday practice of experimental researchers. Instance maps are most effective when applied at the study design stage to associate the workflow with the nanomaterials, environmental conditions, method descriptions, protocols, biological and computational models to be used, and the data flows arising from study execution. Application of the InstanceMaps tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from (i) documentation of a nanomaterial's synthesis, functionalisation, and characterisation, over (ii) assessment of a nanomaterial's transformations in complex media, (iii) description of the culturing of ecotoxicity model organisms Daphnia magna and their use in standardised tests for nanomaterials ecotoxicity assessment, and (iv) visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models, to (v) the use of the instance map approach for the coordination of materials and data flows in complex multipartner collaborative projects and for the demonstration of case studies. Finally, areas for future development of the instance map approach and the tool are highlighted.

Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.

ConspectusA key challenge in modern chemistry research is to mimic life-like functions using simple molecular networks and the integration of such networks into the first functional artificial cell. Central to this endeavor is the development of signaling elements that can regulate the cell function in time and space by producing entities of code with specific information to induce downstream activity. Such artificial signaling motifs can emerge in nonequilibrium systems, exhibiting complex dynamic behavior like bistability, multistability, oscillations, and chaos. However, the de novo, bottom-up design of such systems remains challenging, primarily because the kinetic characteristics and energy aspects yielding bifurcation have not yet been globally defined. We herein review our recent work that focuses on the design and functional analysis of peptide-based networks, propelled by replication reactions and exhibiting bistable behavior. Furthermore, we rationalize and discuss their exploitation and implementation as variable signaling motifs in homogeneous and heterogeneous environments.The bistable reactions constitute reversible second-order autocatalysis as positive feedback to generate two distinct product distributions at steady state (SS), the low-SS and high-SS. Quantitative analyses reveal that a phase transition from simple reversible equilibration dynamics into bistability takes place when the system is continuously fueled, using a reducing agent, to keep it far from equilibrium. In addition, an extensive set of experimental, theoretical, and simulation studies highlight a defined parameter space where bistability operates.Analogous to the arrangement of protein-based bistable motifs in intracellular signaling pathways, sequential concatenation of the synthetic bistable networks is used for signal processing in homogeneous media. The cascaded network output signals are switched and erased or transduced by manipulating the order of addition of the components, allowing it to reach "on demand" either the low-SS or high-SS. The pre-encoded bistable networks are also useful as a programming tool for the downstream regulation of nanoscale materials properties, bridging together the Systems Chemistry and Nanotechnology fields. In such heterogeneous cascade pathways, the outputs of the bistable network serve as input signals for consecutive nanoparticle formation reaction and growth processes, which-depending on the applied conditions-regulate various features of (Au) nanoparticle shape and assembly.Our work enables the design and production of various signaling apparatus that feature higher complexity than previously observed in chemical networks. Future studies, briefly discussed at the end of the Account, will be directed at the design and analysis of more elaborate functionality, such as bistability under flow conditions, multistability, and oscillations. We propose that a profound understanding of the design principles facilitating the replication-based bistability and related functions bear implications for exploring the origin of protein functionality prior to the highly evolved replication-translation-transcription machinery. The integration of our peptide-based signaling motifs within future synthetic cells seems to be a straightforward development of the two alternating states as memory and switch elements for controlling cell growth and division and even communication among different cells. We furthermore suggest that such systems can be introduced into living cells for various biotechnology applications, such as switches for cell temporal and spatial manipulations.

Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery.

Since their inception in the early 1960s, the development and use of nanoscale materials have progressed tremendously, and their roles in diverse fields ranging from human health to energy and electronics are undeniable. The application of nanotechnology inventions has revolutionized many aspects of everyday life including various medical applications and specifically drug delivery systems, maximizing the therapeutic efficacy of the contained drugs by means of bioavailability enhancement or minimization of adverse effects. In this review, we utilize the CAS Content Collection, a vast repository of scientific information extracted from journal and patent publications, to analyze trends in nanoscience research relevant to drug delivery in an effort to provide a comprehensive and detailed picture of the use of nanotechnology in this field. We examine the publication landscape in the area to provide insights into current knowledge advances and developments. We review the major classes of nanosized drug delivery systems, their delivery routes, and targeted diseases. We outline the most discussed concepts and assess the advantages of various nanocarriers. The objective of this review is to provide a broad overview of the evolving landscape of current knowledge regarding nanosized drug delivery systems, to outline challenges, and to evaluate growth opportunities. The merit of the review stems from the extensive, wide-ranging coverage of the most up-to-date scientific information, allowing unmatched breadth of landscape analysis and in-depth insights.

Nanosecond Nanothermometry in an Electron Microscope.

Thermal transport in nanostructures plays a critical role in modern technologies. As devices shrink, techniques that can measure thermal properties at nanometer and nanosecond scales are increasingly needed to capture transient, out-of-equilibrium phenomena. We present a novel pump-probe photon-electron method within a scanning transmission electron microscope (STEM) to map temperature dynamics with unprecedented spatial and temporal resolutions. By combining focused laser-induced heating and synchronized time-resolved monochromated electron energy-loss spectroscopy (EELS), we track phonon, exciton, and plasmon signals in various materials, including silicon nitride, aluminum thin film, and transition metal dichalcogenides. Our results demonstrate the technique's ability to follow temperature changes at the nanometer and nanosecond scales. The experimental data closely matched theoretical heat diffusion models, confirming the method's validity. This approach opens new opportunities to investigate transient thermal phenomena in nanoscale materials, offering valuable insights for applications in thermoelectric devices and nanoelectronics.

Nanoscale Materials in Biomedical Applications of Sensors: Insights from a Comprehensive Landscape Analysis

Nanoscale Materials in Biomedical Applications of Sensors: Insights from a Comprehensive Landscape Analysis

Nanotechnology and nanobots unleashed: pioneering a new era in gynecological cancer management - a comprehensive review.

Gynecological cancers, such as ovarian, cervical, and endometrial malignancies, are notoriously challenging due to their intricate biology and the critical need for precise diagnostic and therapeutic approaches. In recent years, groundbreaking advances in nanotechnology and nanobots have emerged as game-changers in this arena, offering the promise of a new paradigm in cancer management. This comprehensive review delves into the revolutionary potential of these technologies, showcasing their ability to transform the landscape of gynecological oncology. A systematic literature search spanning from March 2005 to August 2024 was conducted using major databases such as PubMed, Google Scholar, and Scopus. Keywords included "nanotechnology," "nanobots," "gynecological cancers," "ovarian cancer," "cervical cancer," and "endometrial cancer." Relevant articles published in English were selected based on their focus on nanotechnology and nanobots in the diagnosis, treatment, and management of gynecological cancers. The findings were synthesized to present a coherent overview of how nanotechnology and nanobots are reshaping gynecological cancer management. The review highlights key innovations, current applications, and future directions for research and clinical implementation. The integration of nanotechnology and nanobots in gynecological cancer management represents a groundbreaking shift in the field. Recent advancements in nanoscale materials and robotic technology offer unprecedented opportunities for precision diagnosis, targeted drug delivery, and innovative therapeutic approaches. Despite promising developments, challenges such as biocompatibility, safety, and regulatory issues remain. Continued research and clinical trials are essential to overcome these hurdles and fully realize the potential of nanotechnology and nanobots.

Nano-scaled advanced materials for antimicrobial applications – mechanistic insight, functional performance measures, and potentials towards sustainability and circularity

About 13.7 million people died worldwide from infectious diseases in 2019 which accounts for one fifth of all annual deaths. Infectious diseases are caused by microbes (i.e. bacteria, fungi, viruses)...

Unravelling the electronic structure, bonding, and magnetic properties of inorganic dysprosocene analogues [Dy(E4)2]- (E = N, P, As, CH).

Organometallic sandwich complexes of Dy(III) ion are ubiquitous for designing high-temperature single-ion magnets with blocking temperatures close to the liquid nitrogen boiling point. Magnetic bistability at the molecular level makes them potential candidates for nano-scale information storage materials. In the present contribution, we have thoroughly investigated the electronic structure, bonding, covalency, and magnetic anisotropy of inorganic dysprosocene complexes with a general formula of [Dy(E4)2]- (where E = N, P, As, CH) using state-of-the-art scalar relativistic density functional theory (SR-DFT), and a multiconfigurational complete active space self-consistent field (CASSCF) method with the N-electron valence perturbation theory (NEVPT2). Geometry optimization calculations predict stabilization of the [Dy(E4)2]- complexes with a linear geometry and D4h local symmetry Dy(III) ion in [Dy(N4)2]- (1) and [Dy(P4)2]- (2) complexes, while a bent geometry has been observed for the [Dy(As4)2]- (3), [Dy(P2(CH)2)2]- (4), and [Dy(As2(CH)2)2]- (5) complexes. Energy decomposition analysis (EDA) and natural bonding orbital (NBO) calculations reveal sizable 5d-ligand covalency followed by 6s/6p and weak 4f-ligand covalency in complexes 1-5. Both the natural localized molecular orbitals (NLMOs) at the DFT level and ab initio-based ligand field theory (AILFT) at the NEVPT2 level of theory predict an increase in the Dy-ligand covalency as we move from N to As. Spin-Hamiltonian parameter analysis of complexes 1-5 reveals stabilization of the mJ |±15/2〉 as the ground state with highly axial g values (gxx ∼ gyy ∼ 0 and gzz ∼ 20) and the barrier height of 2902, 1214, 1104, 1845, and 1509 K for 1-5, respectively. The Orbach effective demagnetization barrier (Ueff) for complexes 1-5 ranges between 2416-1175 K, with a record Ueff value of 2416 K observed for 1. In addition, we have explored the role of heavy element effects on the magnetic anisotropy by turning off the spin-orbit coupling of the pnictogens (N, P, and As), and our calculations clearly predict that heavy atoms in the first coordination sphere help in increasing the barrier height for magnetic relaxation. Heavy elements like P and As significantly enhance the SOC contributions, thereby providing a platform for designing and optimizing Dy(III) complexes with tailored magnetic behaviors.

Nanoformulation innovations: Revolutionizing precision in migraine therapy.

Migraine, a serious neurological disease that affects millions of people worldwide, is one of the most considerable burdens on the healthcare system and has significant economic implications. Even though various treatment methods are available, including medication, lifestyle changes, and behavioral therapy, many migraine sufferers do not receive adequate relief or experience intolerable side effects. Hence, the present review aims to evaluate the nanoformulation regarding migraine therapy. Between 2005 and 2024, specific keywords were used to search several databases, such as Pubmed, Google Scholar, and Scopus. The nanoformulation field is an increasing field within nanotechnology that offers new solutions for treating migraine, including improving drug delivery, increasing therapeutic efficacy, and minimizing side effects. By combining nanoscale materials with therapeutic agents, nanoformulations can enhance bioavailability, sustain drug release, deliver targeted drugs, and penetrate the Blood-Brain Barrier (BBB) more efficiently. Nanoformulation has the potential to be a useful tool for migraine therapy. However, several challenges still need to be overcome, such as the BBB penetration, safety and biocompatibility of the product, manufacturing, and scalability reproducibility to pass regulatory approval and affordability. To overcome these challenges, research efforts should be focused on developing innovative techniques to penetrate the BBB, target specific migraine pathways, incorporate personalized medicine approaches, and develop nanotechnology-based diagnostics. A nanotechnology-based approach aims to revolutionize migraine therapy, improving patient outcomes and living standards by offering personalized and precise treatments.

In Ukrainian

The immobilisation of medicinal substances, in particular antibiotics of the anthracycline series, on the surface of nanosized carriers for the targeted delivery of drugs to target organs or target tissues allows the creation of an optimal concentration of the drug in the area of therapeutic effect. Doxorubicin is a drug that interacts with DNA and is a common component of chemotherapy regimens. The toxic effect of doxorubicin represents a significant challenge to the implementation of highly effective cytostatic chemotherapy, providing a compelling rationale for treatment cessation even before the attainment of a clear antitumour effect. In particular, nanoscale carbon materials, such as carbon nanotubes (CNTs), are emerging as promising auxiliary substances. Nevertheless, the particulars of the interaction between doxorubicin and CNTs at the atomic level remain insufficiently understood. It is therefore important to investigate the energy parameters of the interaction between single-walled CNTs and doxorubicin in its various protolytic forms, which exist at different pH values in aqueous media, using quantum chemistry methods. Furthermore, it is also important to investigate how the diameter of CNTs affects the adsorption properties of doxorubicin in different protolytic forms. The results of the quantum chemical calculations indicate that all values of ΔH298 for intermolecular interactions are negative, which suggests that the adsorption process for all considered protonated forms of doxorubicin on the outer surface of the nanotube is thermodynamically self-activating, irrespective of the nanotube diameter. At pH values below 7, the protonated form of doxorubicin exhibits the greatest enthalpy of adsorption on CNTs, irrespective of the diameter of the carbon nanotube fragment. As the diameter of the carbon nanotube increases, the intermolecular interaction energy rises for both the molecular and protonated forms of doxorubicin. The lowest value of the enthalpy of interaction was observed for the molecular form of doxorubicin and the smallest CNT (diameter 10 Å). Conversely, the highest value of the interaction enthalpy was recorded for the protonated form of doxorubicin and the maximum size CNT (diameter 20 Å).

Experimental and Theoretical Study of Sc2O3 Nanoparticles Under High Pressure

This study investigates the high-pressure structural and vibrational properties of nano-Sc2O3 using a combination of X-ray diffraction, Raman spectroscopy, and theoretical calculations. Nano-Sc2O3 maintains its cubic bixbyite structure up to 26.4 GPa, without evidence of phase transitions, contrasting with bulk Sc2O3, which transitions to a monoclinic phase around 25–28 GPa. Raman spectroscopy reveals a pressure-induced blue shift in the vibrational modes, indicating lattice compression, and the absence of new modes confirms the retention of the cubic symmetry. Theoretical predictions using density functional theory (DFT) closely match the experimental data, validating the computational approach we use to model the pressure-dependent vibrational behavior of nano-Sc2O3. Comparisons with previous studies seem to show that the nanoscale material exhibits enhanced structural stability compared to its bulk counterpart, likely due to size effects and surface energy contributions. These findings provide new insights into the behavior of nanomaterials under extreme conditions and highlight the potential applications of nano-Sc2O3 in high-pressure environments.

Kinetics, isotherms, and thermodynamics: caesium ion adsorption on titanate nanostructures from aqueous solutions

ABSTRACT Releasing radioactive caesium ions (Cs+) from nuclear industries into natural water bodies poses significant environmental challenges. Meanwhile, various treatment methods have been applied to mitigate the presence of this detrimental pollutant in water sources. The utilisation of adsorption technology using nanoscale materials seems to hold promising potential for reducing Cs+ levels in water resources. This research has been conducted to evaluate the caesium ions adsorption using synthesised titanate nanotubes (TNT) and titanate nanofibers (TNF) produced via the hydrothermal method under highly alkaline conditions. The XRD, SEM, TEM, BET, TGA, and Zeta-potential analysis were used to characterisation the synthesised absorbents. Adsorption of Cs+ ions on TNT and TNF based on various parameters such as contact time, pH, initial concentration, adsorbent weight, and temperature have been investigated through batch experiments. The adsorption kinetics are best described by the pseudo-second-order model, whereas the Langmuir model is more consistent with adsorption isotherms. The maximum adsorption capacity for caesium ions was determined to be 175.44 mg.g−1 and 104.17 mg.g−1 at 298 K for TNT and TNF, respectively, with 80% and 72% removal rates. The separation factor (RL) value for TNT is 0.5370, and for TNF, it is 0.6570, confirming the favourability of adsorption. Thermodynamic assessments indicate that adsorption onto both adsorbents is favourable, spontaneous, and endothermic. The physisorption is the most likely mechanism for adsorption. A comparative assessment showed that titanate nanotubes outperform titanate nanofibers in terms of caesium ion adsorption capacity and efficiency.

Nanotechnology based approaches for leukemia therapy

Leukemia, a leading cause of cancer-related morbidity and mortality, primarily affect blood-forming tissues. It is classified into four main types: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and chronic lymphocytic leukemia (CLL). These subtypes vary in characteristics and prevalence, affecting different age groups, from children to adults, with prognosis heavily influenced by the type and severity of the disease. Conventional treatments for leukemia, including chemotherapy, radiation, and stem cell therapy, have notable limitations, such as non-specific targeting, high costs, drug resistance, and issues related to donor compatibility. These limitations underscore the urgent need for innovative solutions. One of the major challenges in treating leukemia with tyrosine kinase inhibitors (TKIs) is the frequent resistance due to factors like lack of specific targeting, underdosing, limited bioavailability, and severe adverse effects. Nanotechnology presents a promising solution to these challenges by utilizing nanoscale materials such as liposomes, metallic nanoparticles, polymeric nanoparticles, and biomimetic nanoparticles for targeted drug delivery. Nanoparticle-based drug delivery systems offer enhanced drug targeting, reduced systemic toxicity, and improved therapeutic efficacy. This review highlights recent advancements in nanotechnology to improve leukemia treatment.

A modified spatiotemporal nonlocal thermoelasticity theory with higher-order phase delays for a viscoelastic micropolar medium exposed to short-pulse laser excitation

At the microscale and nanoscale, materials exhibit size-dependent behaviors that classical models cannot capture. This analysis introduces a size-dependent higher-order thermoelastic heat conduction model, incorporating spatial and temporal nonlocal effects in a micropolar visco-thermoelastic medium subjected to laser pulse heat flux. The two-phase delay model, featuring higher-order temporal derivatives, captures the complex interactions among mechanical, thermal, and viscous properties in materials where size effects are significant. By including phase lag, the model effectively addresses non-Fourier heat conduction in short-duration laser pulse scenarios. It accurately predicts temperature distribution, stress response, and microrotation effects in microscale and nanoscale materials. The study visually represents how factors such as micropolarity, higher-order effects, phase delay, nonlocal index, and viscosity influence the size-dependent mechanical behavior of the half-space structure. The numerical results highlight the importance of size-dependent phenomena in nanostructures, revealing deviations from classical predictions due to nonlocal interactions. Overall, the proposed spatiotemporal nonlocal homogenization model serves as a valuable tool for analyzing the complex mechanical and thermal characteristics of nanomaterials.

Nanotechnology in prosthodontics – Small particles big impact

Nearly every aspect of research and development has been significantly impacted by nanotechnology. Notably, nanotechnology is also having an impact on the fields of health and dentistry by utilising its enormous potential. When compared to bulk material, nanoparticles have proven to be far more powerful. Because of its unusual size, it is much easier to change and improve a variety of features, including surface chemistry, charge, bonding ability, and different biological properties. Richard P. Feynman, a late Nobel Prize-winning physicist, developed the idea in 1959. The area was researched in the years that followed for the creation of nanoscale devices and nanosized particles to produce improved qualities. Regularly used dental materials with limitations of inferior physical and biologic qualities can be changed with nanoparticles to improve the material's inherent properties while staying within budgetary constraints. Unique qualities of a nanoscale material may not only have a significant impact on its biological properties, such as cytotoxicity and biocompatibility, but also on its physical properties, such as tensile strength, fracture resistance, and surface hydrophobicity.

Innovative Applications of Nanocellulose in 3D Printing: A Review.

Cellulose nanofibrils (CNFs) and cellulose nanocrystals (CNCs) are nanoscale materials with unique mechanical properties and geometry that attract considerable interest in recent years for a wide range of applications. This review pays special attention to the recent progress of CNFs and CNCs assisted 3D printing in medicine, food, engineering, and architecture fields. Various types of CNFs and CNCs used for 3D printing are summarized. The addition of nanocellulose improves the printability and quality of printed objects in certain cases, leading to greater accuracy and durability. The created functional structures with specific properties have promising applications in various fields such as medicine and food preservation and viscosity enhancement. Finally, this work highlights the transformative potential of nanocellulose-assisted 3D printing to revolutionize a range of fields and the need for continued research and development to overcome current technical challenges.