As an alternative to chemical and physical approaches, green synthesis of metal nanoparticles is a developing area in the field of bio-nanotechnology and offers economic and environmental benefits. In the field of health and hygiene, engineered metal nanoparticles have increased their popularity due to their effectiveness in penetrating living systems. Metal nanoparticles can be efficiently biosynthesized using a range of microbes and plant extracts. Green synthesis of these nanoparticles and their use in diverse technologies have a bright future due to the shifting perspectives of the international community on sustainable development, environmental improvement, and the reduction of dangerous man-made waste. The focus of the current review was primarily on various methods employed for the green synthesis of metal nanoparticles, which is a more environment-friendly technique for creating metallic nanocarriers and altering their surfaces, use these metal nanoparticles, including metal sulfides, zinc oxide, copper, gold, platinum, and palladium, as well as nano metal-organic frameworks, in drug delivery systems.