This paper presents the synthesis and design optimization of a compact and yet economical hybrid two-fingered micro–nano manipulator hand. The proposed manipulator hand consists of two series modules, i.e., an upper and lower modules. Each of them consists of a parallel kinematics chain with a glass pipette (1 mm diameter and 3–10 cm length) tapered to a very sharp end as an end-effector. It is driven by three piezo-electric actuated prismatic joints in each of the three legs of the parallel kinematics chain. Each leg of the kinematics chain has the prismatic–revolute–spherical joint structure. As the length of the glass pipette end-effector is decreased, the resolution and accuracy of the micro–nano manipulator hand is increased. For long lengths of the glass pipette end-effector, this manipulator works as a micro manipulator and for short lengths it works as a nano manipulator. A novel closed-form solution for the problem of inverse kinematics is obtained. Based on this solution, a simulation program has been developed to optimally choose the design parameters of each module so that the manipulator will have a maximum workspace volume. A computer-aided design model based on optimal parameters is built and investigated to check its workspace volume. Experimental work has been carried out for the purpose of calibration. Also, the system hardware setup of the hybrid two-fingered micro–nano manipulator hand and its practical Jacobian inverse matrices are presented.