Nanjing University Research Articles

Prenatal diagnosis and outcome of pregnancy for women with high risks by screening of fetal free DNA from peripheral blood samples

To analyze the results of prenatal diagnosis and outcome of pregnancy for women with a high risk for fetal aneuploidies. A total of 747 cases of prenatal diagnosis by amniocentesis due to high risks by non-invasive prenatal testing (NIPT) were selected from January 2015 to March 2022 in the Drum Tower Hospital Affiliated to Nanjing University Medical School. The amniotic fluid samples were subjected to chromosomal karyotyping and/or chromosomal microarray analysis. All cases were followed up by searching the birth information or telephone calls, and the results were recorded. 2 test or F test were used for comparing the difference between the groups. Among the 747 pregnant women with a high risk by NIPT, 387 were true positives, and the overall positive predictive value (PPV) was 51.81%. The PPVs for trisomy 21 (T21), trisomy 18 (T18), trisomy 13 (T13) and sex chromosome aneuploidies (SCA) were 80.24% (199/248), 60% (48/80), 14% (7/50) and 38.97% (106/272), respectively. The PPV for T21 was significantly higher than T18 and T13 (χ2 = 85.216, P < 0.0001). The PPV for other chromosomal aneuploidies and copy number variations (CNVs) were 11.11% (5/45) and 40.74% (22/52), respectively. The PPV for increased X chromosomes was significantly higher than X chromosome decreases (64.29% vs. 22.22%, χ2 = 5.530, P < 0.05). The overall PPV for elder women (≥ 35 years old) was significantly higher than younger women (69.35% vs. 42.39%, χ2 = 49.440, P < 0.0001). For T21 and T18, the PPV of Z ≥ 10 group was significantly higher than that for 3 ≤ Z < 5 group or 5 ≤ Z < 10 group (P < 0.05). Among 52 cases with a high risk for CNVs, the PPV for the ≤ 5 Mb group was significantly higher than the 5 Mb < CNVs < 10 Mb or > 10 Mb groups (60% vs. 30%60% vs. 23.53%, P < 0.05). Among the 387 true positive cases, 322 had opted for induced labor, 53 had delivered with no abnormal growth and development, and 12 were lost during the follow-up. The PPVs for common chromosomal aneuploidies are related to the age and Z value of the pregnant women, which were higher in the elder group and higher Z value group. In addition, the PPV is associated with high risk types. The PPV for T21 was higher than T18 and T13, and that for 45,X was lower than 47,XXX, 47,XYY or 47,XXY syndrome. NIPT therefore has relatively high PPVs for the identification of chromosomal CNVs.

A bibliometric analysis of deep learning applications in climate change research using CiteSpace

&lt;p&gt;In recent years, artificial intelligence, particularly deep learning, has garnered significant attention among practitioners and scholars in meteorology and atmospheric sciences, leading to a substantial body of literature. This study aims to delineate the present research status and trends in climate innovation through CiteSpace visual analysis. To comprehend the current landscape, prevalent terms, and research frontiers of deep learning for climate change research (DLCCR) within meteorology and atmospheric applications, we gathered 256 published papers spanning from 2018 to 2022 from the Web of Science (WOS) core database. Employing these articles, we conducted co-authorship, co-citation, and keyword co-occurrence analyses. The findings unveiled a steady rise in DLCCR publications over the last five years. However, the correlation between high yield and high-citation authorship appears inconsistent and weak. Notably, prolific authors in this domain included Zhang Z.L. and Bonnet P. Furthermore, leading institutions such as the Chinese Academy of Sciences (China), le Centre National de la Recherche Scientifique (France), and Nanjing University of Information Science and Technology (China) have played pivotal roles in advancing DLCCR. The primary contributors among high-yield countries primarily cluster in a select group comprising China, the USA, South Korea, and Germany. Identifying significant information gaps in numerical weather, atmospheric physics and processes, algorithm parametrizations, and extreme events, our study underscores the necessity for future researchers to focus on these and related subjects. This study provides valuable insights into research hotspots, developmental trajectories, and emerging frontiers, thereby delineating the knowledge structure in this field and highlighting directions for further climate innovation research.&lt;/p&gt;

Reconstruction of a century of air pollution history in Nanjing, China, using trace elements in situ leaf specimens of Platanus × hispanica and Pittosporum tobira

Leaves can specifically uptake trace elements from the surrounding environment. And tree leaves are a good biological indicator for air pollution. Therefore, chemical analysis of leaf specifications can be used to reproduce a historical record of air pollution. To better understand the history of urban air pollution from the 1920s to the 2020s in Nanjing, China, leaf samples of two woody plants, Platanus × hispanica and Pittosporum tobira, were collected in this study as environmental indicators from different historical periods. These included historical herbarium specimens and current leaves from live trees. The concentrations of 10 trace elements were determined in the samples using ICP‒MS. Pollution indices were calculated, yielding the key findings. The historical leaf samples showed continuously increasing mean concentrations of the 10 trace elements over time, which significantly correlating with automobile quantities and the number of large-scale industrial enterprises (p < 0.05). Moreover, modern leaf trace element concentrations were significantly correlated with PM10, PM2.5, automobiles, large-scale industrial enterprises, and atmospheric factors, confirming these as sources. In addition to the historical growth trend, spatial heterogeneity was revealed in historical Platanus × hispanica leaf samples from the 14 sites in Nanjing. Changes in heavy metal trace element pollution distributions were consistent with transportation and industrial expansion, with homologous patterns across elements. Specifically, post 1980s increases were observed in the representative NJ2 (Zhongshan Botanical Garden) and the NJ5(Nanjing University) sites, with higher concentrations occurring at in the NJ5 contaminated site than at the NJ2 uncontaminated site. After 2009, the 10 element (except Cd) pollution indices in Platanus × hispanica leaves fluctuated but declined overall. This reconstruction of Nanjing's air pollution history demonstrates that ample environmental information can be extracted from plant leaf markers over time and space.

Research on the Paths of Promoting the University Governance by Law—Take C University in Nanjing as an Example

Research on the Paths of Promoting the University Governance by Law—Take C University in Nanjing as an Example

Preface

This volume contains a unique collection of papers collected at 2023 2nd International Conference on Mechanical, Aerospace Technology and Materials Application (MATMA 2023), which took place in Shenyang, China from September 15th to 17th, 2023 (hybrid conference). Each paper recognizes the seminal contributions to mechanical and aerospace technology and materials made by every author, and acknowledges their impact on their own researches.All the scientific participants, many of whom were students, had many fruitful discussions and exchanges that contributed to the success of the Conference. Participants from about 10 countries made the Conference truly international in scope.There were 3 plenary keynote speeches by renowned professors covering different topics of the Conference theme: Prof. Junhui Hu (Nanjing University of Aeronautics and Astronautics, China) talked on The BAW Based Ultrasonic Manipulation and Fabrication of Micro/Nano Scale Materials, Prof. Kun Li (Chongqing University, China) on Additive Manufacturing and Intelligent Control of High-Performance Metal Materials, and Prof. Laichang Zhang (ECU’s School of Engineering, Australia) on Processing Optimization and Mechanical Performance of Titaniumalloys Fabricated by Powder Bed Fusion. The speakers gave very illuminating speeches that drew many people’s full attention. These speeches, held on Saturday morning, were very accessible to the general audience. In addition, there were quantities of oral and poster presentations on ongoing current researches. These presentations cover the full range of the Conference topics, which include Aerospace Design, Testing and Performance, Aerodynamics and Control, Nanotechnology, Special High-Performance Materials, Combustion and Emission Control, etc.All in all, the 2nd International Conference on Mechanical, Aerospace Technology and Materials Application held in Shenyang was very successful. The plenary speeches and the progress and oral reports bridged the gap between different fields related to mechanical and aerospace technology and materials, making it possible for non-experts in a given area to gain insights into new areas. Also, included among the speakers were several young scientists, who brought new perspectives to their fields.We would like to acknowledge the authors of the papers collected in this present volume, the members of Technical Program Committee and Organizing Committee for their guidance and support, and the referees for their generous work. Our thanks also go to the editors and other staff of Journal of Physics: Conference Series, for their time and kindness in waiting for the final submission of the papers.Given the rapidity with which science is advancing in all the areas covered by MATMA, we expect that these future series conferences of MATMA will be as stimulating as this most recent one was, as indicated by the contributions presented in this Proceedings volume.The Committee of MATMA 2023List of Committee Member is available in this pdf.

Quantifying carotid stiffness in chronic kidney disease using ultrafast ultrasound imaging.

The mortality and disability of chronic kidney disease (CKD) are highly linked to the incidence of atherosclerotic cardiovascular events. Numerous clinical biochemical indicators of renal function often only increase in advanced stages of CKD, driving an urgent need for reliable indicators of atherosclerosis in early CKD. Ultrafast pulse wave velocity (ufPWV) can evaluate the stiffness of the straight carotid in vivo and quantitatively reflect the degree of early atherosclerosis. However, the use of ufPWV in CKD has not yet been reported. In this study, we aimed to explore the association between carotid stiffness, quantified using ufPWV, and renal function in CKD patients. This cross-sectional study enrolled a total of 582 participants between March 2017 and May 2022 in the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine. Among those, 205 individuals without a history of CKD and estimated glomerular filtration rate (eGFR) ≥90 mL/min/1.73 m2 were included as controls. According to the Kidney Disease Outcomes Quality Initiative (K/DOQI) expert group of the American Kidney Foundation staging for CKD, 44 stages 1 and 2 CKD patients were included in the early CKD group, whereas 49 stages 3, 4, and 5 CKD patients were included in the advanced CKD group. Clinical and serum parameters, ultrasonic characteristics including carotid intima-media thickness (cIMT), and pulse wave velocity at the beginning of systole (PWV-BS) and pulse wave velocity at the end of systole (PWV-ES) of systole were analyzed. One-way analysis of variance (ANOVA) and least significant difference (LSD) tests were performed to compare cIMT, PWV-BS, and PWV-ES among subgroups in pairs. Pearson's correlation analysis, scatter plots, and subgroups correlation analysis were used to determine the relationships among ultrasound characteristics (cIMT, PWV-BS, PWV-ES), and major cardiovascular risk factors. PWV-BS and PWV-ES for the early and advanced CKD groups were significantly higher than those for controls (all P<0.05). PWV-ES had the greatest correlation with age (r=0.474, P<0.001). PWV-ES had the greatest increase with age in the early CKD group (r=0.698, P<0.001). ufPWV can be used for the quantitative evaluation of carotid stiffness in CKD patients. PWV-ES may be more advantageous in the assessment of carotid atherosclerosis in early CKD patients.

Chem&amp;Bio Interdisciplinary Graduates Training in Nanjing University Promoted by Chemistry and Biomedicine Innovation Center

Chem&amp;Bio Interdisciplinary Graduates Training in Nanjing University Promoted by Chemistry and Biomedicine Innovation Center

중국에서 문화지리학의 태동과 발전

Examining the emergence and development of cultural geography in China, this study aims to identify major researchers and research trends by generation and to identify major research bases and characteristics by region as well. For these purposes, we tracked the master-apprentice relationship of scholars who published cultural geographical studies in major geographical journals in China. According to the generation classification, scholars could be divided into five generations in this study. Geographical study of culture started in the Huadong region centered on Nanjing University was found to be divided into two bases: Beijing and Guangzhou. Although it is nearly 100 years since geographical study of culture emerged in China, cultural geography was firstly introduced to universities as a course by the third generation scholars in the mid-1980s, shortly after the Chinese economic reform. Leading the research from the late 1990s to the late 2010s, the fourth generation had contributed to the transition from ‘historical and cultural geography’ that inherited from earlier generations to ‘social and cultural geography’. The fifth generation, who began academic activities in the 2010s, has switched to ‘social and cultural geography.’ We argue that ‘institutional sustainability’ and ‘critical mind on issues in China’ are the tasks of Chinese cultural geography.

Clinicopathological and molecular features of metaplastic thymoma

Objective: To investigate the clinicopathological features, and molecular genetic alterations of metaplastic thymoma (MT). Methods: A total of ten MT cases, diagnosed from 2011 to 2021, were selected from the Department of Pathology of Jinling Hospital, Nanjing University Medical School, Nanjing, China for clinicopathological and immunohistochemical (IHC) examination and clinical follow-up. Fluorescence in situ hybridization (FISH), next-generation sequencing (NGS), and YAP1 C-terminus (YAP1-CT) IHC were performed to detect YAP1::MAML2 fusions. Results: There were four males and six females, ranging in age from 29 to 60 years (mean 50 years, median 54 years). Microscopically, all tumors showed a typical biphasic morphology consisting of epithelial components and gradually or abruptly transitioning spindle cell components. The two components were present in varying proportions in different cases. Immunophenotypically, the epithelial cells were diffusely positive for CKpan, CK5/6 and p63. The spindle cells were diffusely positive for vimentin and focally positive for EMA. TdT was negative in the background lymphocytes. Ki-67 proliferation index was less than 5%. YAP1 and MAML2 break-apart FISH analyses showed that all ten cases had narrow split signals with a distance of nearly 2 signal diameters and may be considered false-negative. Using YAP1::MAML2 fusion FISH assays, abnormal fusion signals were observed in all the ten cases. NGS demonstrated YAP1::MAML2 fusions in all eight cases with adequate nucleic acids; in two cases the fusions were detected by DNA sequencing and in eight cases by RNA sequencing. All ten cases of MT demonstrated loss of YAP1 C-terminal expression in epithelioid cells. Conclusions: MT is a rare and low-grade thymic tumor characterized by a biphasic pattern and YAP1::MAML2 fusions. Break-apart FISH assays may sometimes show false-negative results due to the proximity of YAP1 and MAML2, while YAP1 C-terminal IHC is a highly sensitive and specific marker for MT. Loss of YAP1 C-terminal expression can also be used to screen YAP1::MAML2 fusions for possible MT cases.

Knowledge mapping of idiopathic scoliosis genes and research hotspots (2002-2022): a bibliometric analysis.

The etiology of idiopathic scoliosis (IS) remains unclear. Gene-based studies on genetic etiology and molecular mechanisms have improved our understanding of IS and guided treatment and diagnosis. Therefore, it is imperative to explicate and demarcate the preponderant areas of inquiry, key scholars, and their aggregate scholarly output, in addition to the collaborative associations amongst publications or researchers. Documents were retrieved from the Web of Science Core Collection (WoSCC) with the following criteria: TS = ("idiopathic scoliosis" AND gene) refined by search operators (genomic OR "hereditary substance" OR "germ plasm" OR Cistrons OR genetics OR genetic OR genes OR Polygenic OR genotype OR genome OR allele OR polygenes OR Polygene) AND DOCUMENT TYPES (ARTICLE OR REVIEW), and the timespan of 2002-01-01 to 2022-11-26. The online bibliometric analysis platform (bibliometric), bibliographic item co-occurrence matrix builder (BICOMB), CiteSpace 6.1. R6 and VOS viewer were used to evaluate articles for publications, nations, institutions, journals, references, knowledge bases, keywords, and research hotspots. A total of 479 documents were retrieved from WoSCC. Fourty-four countries published relevant articles. The country with the most significant number of articles was China, and the institution with the most significant number of articles was Nanjing University. Citation analysis formed eight meaningful clusters and 16 high-frequency keywords. (2) The citation knowledge map included single nucleotide polymorphisms, whole exome sequencing, axonal dynamin, drug development, mesenchymal stem cells, dietary intake, curve progression, zebrafish development model, extracellular matrix, and rare variants were the current research hotspots and frontiers. Recent research has focused on IS-related genes, whereas the extracellular matrix and unusual variants are research frontiers and hotspots. Functional analysis of susceptibility genes will prove to be valuable for identifying this disease.

The Application of Cognitive Linguistics Theory in Japanese Language Teaching in the Age of Artificial Intelligence

Abstract This paper firstly summarizes the tense expressions in Japanese, Chinese and English according to the cognitive linguistics theory so as to derive the grammatical transformation law in the process of Japanese to Chinese or Japanese to English. Secondly, on the basis of artificial intelligence technology, a hierarchical Japanese phrase model based on maximum entropy tense classification features is proposed, and the extraction of Japanese phrase rules is realized through maximum entropy mathematical modeling to obtain the model feature function and decoding strategy, and the application of the model in Japanese language teaching is explained in the research. Then, the second-year students of Japanese language major in the School of Foreign Studies, Nanjing University of Posts and Telecommunications are selected as the research objects, research tools and experimental process are determined, and simulation analysis and statistical analysis are used to analyze the example of Japanese language teaching with the integration of artificial intelligence. The results show that on the model, compared with the baseline, the model in this paper improves the blue value by 0.64%, the comprehensibility by 4.39%, and the tense accuracy by 4.14% on the whole test set, which verifies the effectiveness of the hierarchical phrase model fused with the tense features proposed in this paper in Japanese-Chinese translation. In terms of Japanese language teaching, the independent samples t-test p-values were less than 0.05, and the students in class A outperformed the students in class B in the four question types: multiple choice, sentence ordering, Chinese-to-Japanese translation and composition. This study improves students’ language proficiency and achieves the objective of developing high-quality talents.

Innovative Telerehabilitation Enhanced Care Programme (ITECP) in young and middle-aged patients with haemorrhagic stroke to improve exercise adherence: protocol of a multicentre randomised controlled trial

IntroductionExercise rehabilitation is crucial for promoting the rehabilitation of limb motor function in people who had stroke and is related to a better prognosis. However, the exercise adherence of patients...

Fostering talents in biotechnology major through the university-enterprise collaborative training mode

With the high-quality development of biotechnology-related industries in China, the demand for talents and training quality in this field have received extensive attention. Several universities in Nanjing have conducted in-depth analysis on the shortcomings of talent training that does not closely match the needs of industries and enterprises. These universities have since effectively leveraged its professional characteristics, deepened university-enterprise cooperation, and encouraged the alignment of professional development with industrial growth. Biotechnology major has always focused on nurturing individuals with "right conduct, good learning, and strong ability", and capitalized on its comparative disciplinary advantages. These universities vigorously promoted and continuously optimized the model of university-enterprise collaborative training, highlighted the integration of science, industry and education, focused on innovative education teaching methods, as well as practical engineering practice to enhance its quality. The preliminary training results show that this model has promoted students' engineering practical abilities and comprehensive qualities, garnering recognition from employers and students alike.

RATIONALITY ANALYSIS OF UNIVERSITY BRAND IMPLEMENTATION PATH

Brand is a socio-economic phenomenon. Brand is the product of the development of commodity economy to a certain stage. The generation of brand marks the maturity of the concept in the process of commodity exchange. To simply define a brand, it refers to a name, symbol, symbol or design of a seller or service, highlighting its competitive advantage and being distinguished from its competitors. In tandem with trends toward the popularization, marketization, and internationalization of higher education, brand marketing emerged in the field of higher education in the 1980s. In addition, with improvements in social welfare and new forms of public management, the commercialization and marketization of higher education have attracted increasing attention. The definition of the university brand can be described as that the university brand is the organic combination of representation information (name, noun, mark or design) and profound connotation (value, culture, personality and spirit), so that it is distinguished from competitors and recognized by consumers. Brand strategy is the overall planning and implementation of brand building and future development carried out by brand institutions under the guidance of brand strategic thinking based on their own conditions and analysis of the current situation and future trends of the external competitive environment. The essence of brand strategy is to shape the core expertise of the company, thereby ensuring its long-term development. Brand strategy is to establish a corporate strategy centered on building a strong brand. The core of raising brand building to the business strategy of a company lies in establishing a distinctive brand identity. Through the analysis of the actual situation and future trend of the external competitive environment, according to the guidance of its own conditions, the university conducts the overall planning and implementation of the future development of the university under the guidance of brand strategic thought. The C9 Alliance is the first university alliance between top universities in China. The alliance includes nine universities, including Peking University, Tsinghua University, Zhejiang University, Fudan University, Shanghai Jiao Tong University, Nanjing University, University of Science and Technology of China, Xi'an Jiaotong University and Harbin Institute of Technology. Its development model, development path, talent training and other aspects are the target of many Chinese universities. Centering on the connotation of university brand, this paper analyzes the brand implementation road of "C9 Alliance" university to prove the rationality of the model observation point proposed in this paper, and on this basis, puts forward reference suggestions on the implementation path of ordinary undergraduate university brand.

Analysis on Strengthening the Construction of School Spirit in Private Independent Colleges and Universities

Private independent colleges and universities shoulder the responsibility of training application-oriented talents. Teaching atmosphere, learning atmosphere, research atmosphere is not only related to the quality of talent training and the level of school running, but also related to the healthy development of independent colleges and universities themselves. This paper analyzes and discusses the core connotation and index system of the school spirit construction of China’s private independent colleges and universities: using the method of literature, investigation and research, inclusion and summary and logical analysis, strengthening the construction of the study style, advocating scientific research, and constructing three-dimensional figures of “finding problems, analyzing problems, and solving problems”. Taking nanjing tech university pujiang institute as the research object, this paper puts forward some ideas and countermeasures to strengthen the construction of school spirit. It provides some theoretical and practical guidance for the evaluation system of campus atmosphere construction of private independent colleges in China.

Path to Improve the Professional Quality of Students Majoring in Financial News: Micro Evidence from 300 Questionnaires from Three Universities

&lt;p class="MsoNormal" style="margin-top: 12pt; text-align: justify;"&gt;&lt;span lang="EN-US" style="font-family: arial, helvetica, sans-serif;"&gt;There must be a better match between the supply of financial news graduates in colleges and the media's demand for financial news talents. Based on 300 questionnaires and in-depth interviews from three universities, namely Shanghai University of Finance and Economics, Nanjing University of Finance and Economics, and Jiangxi University of Finance and Economics, this paper uses the interview method to excavate the professional quality improvement path for majoring in financial news students. Results reveal that undergraduates majoring in financial news have problems such as low professional identity, insufficient recognition of the discipline system, poor sense of professional identity, common matching between job selection and majors, and worrying about the status quo of professional literacy. Therefore, the improvement of the professional quality of students majoring in financial news and the reform of the training program needs to drive the professional quality of students in multiple dimensions, change their professional cognitive problems, strengthen their professional identity, and achieve an effective match between supply and demand of financial media professionals.&lt;/span&gt;&lt;/p&gt;

Unveiling the nexus of postoperative fever and delirium in cardiac surgery: identifying predictors for enhanced patient care.

Postoperative delirium (POD) is a significant complication observed in cardiac surgery patients, characterized by acute cognitive decline, fluctuating mental status, consciousness impairment, and confusion. Despite its impact, POD often goes undiagnosed. Postoperative fever, a common occurrence after cardiac surgery, has not been comprehensively studied in relation to delirium. This study aims to identify perioperative period factors associated with POD in patients undergoing cardiopulmonary bypass, with the potential for implementing preventive interventions. In a prospective observational study conducted between February 2023 and April 2023 at the Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, a total of 232 patients who underwent cardiac surgery were enrolled. POD assessment utilized the Confusion Assessment Method for the ICU (CAM-ICU), while high fever was defined as a bladder temperature exceeding 39°C. Statistical analysis included univariate and multivariate analyses, logistic regression, nomogram development, and internal validation. The overall incidence of postoperative delirium was found to be 12.1%. Multivariate analysis revealed that postoperative lactate levels [odds ratio (OR) = 1.787], maximum temperature (OR = 11.290), and cardiopulmonary bypass time (OR = 1.015) were independent predictors of POD. A predictive nomogram for POD was developed based on these three factors, demonstrating good discrimination and calibration. The prediction model exhibited a C-statistic value of 0.852 (95% CI, 0.763-0.941), demonstrating excellent discriminatory power. Sensitivity and specificity, based on the area under the receiver operating characteristic (AUROC) curve, were 91.2% and 67.9%, respectively. This study underscores the high prevalence of POD in cardiac surgery patients and identifies postoperative lactate levels, cardiopulmonary bypass duration, and postoperative fever as independent predictors of delirium. The association between postoperative fever and POD warrants further investigation. These findings have implications for implementing preventive strategies in high-risk patients, aiming to mitigate postoperative complications and improve patient outcomes.

The predictive values of platelet mitochondrial mass and quantity during the perioperative period in elderly patients on the occurrence of postoperative delirium

Objective: To investigate the changes of platelet mitochondrial mass and quantity during perioperative period in elderly patients, and assess their predictive values on the occurrence of postoperative delirium (POD). Methods: In this prospective study, 162 elderly patients scheduled for abdominal surgery under general anesthesia were enrolled from November 2021 to January 2022 in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School. Among them, 20 patients [10 males, 10 females, aged (71.4±6.8) years] developed POD within 3 days after surgery (POD group), and another 20 patients[12 males, 8 females, aged (67.7±5.3) years] who did not develope POD were selected as controls (control group) using propensity score matching method. Blood samples were collected preoperatively, at the end of surgery and on the first postoperative day. Platelets were extracted and mitochondrial mass was detected with flow cytometry. Transmission electron microscopy was used to determine mitochondrial quantity. The receiver operating characteristic (ROC) curve was drawn to analyze the value of mitochondrial mass and quantity in predicting the occurrence of POD. Results: The mean fluorescence intensities of platelet mitochondrial mass were 193±46, 236±61, 264±53 preoperatively, at the end of surgery and on the first postoperative day in the POD group, respectively. The corresponding values were 209±61, 191±67 and 201±56 in the control group. The platelet mitochondrial mass of patients in the POD group was significantly increased on the first postoperative day compared to preoperative levels (P<0.001). In contrast, there was no significant difference in the control group (P=0.410). Patients in the POD group had higher platelet mitochondrial mass than patients in the control group on the first postoperative day(P=0.002). Meanwhile, platelets from patients in the POD group showed significantly higher number of mitochondria than platelets from patients in the control group [3 (2, 4) vs 2 (1, 2), P<0.001]. According to the ROC curve of platelet on the first postoperative day, at a mitochondrial mass cut-off value of>275.35, the sensitivity, specificity and area under the ROC curve to detect the occurrence of POD were 55%, 90% and 0.800 (95%CI: 0.666-0.934, P<0.001). At a mitochondrial quantity cut-off value of>2, the sensitivity, specificity and area under the ROC curve to detect the occurrence of POD were 53%, 78% and 0.680 (95%CI: 0.584-0.776, P<0.001). Conclusions: Patients who developed POD show higher platelet mitochondrial mass after surgery compared to preoperative levels. The mitochondrial mass of platelets on the first postoperative day has good predictive value on the occurrence of POD.

A commentary on 'Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: a retrospective cohort study' ( Int J Surg 2022;105:106843).

aDepartment of General Surgery, Nanjing Drum Tower Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Graduate School of Peking Union Medical College bSchool of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine cDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. Published online ■ ■ *Corresponding author. Address: Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, No. 321, Zhongshan Road, Nanjing 210008, China. Tel: 86-13357851195; fax: 86-25-86560946. E-mail address: [email protected] (X. Xu). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

Preface

The Asian Aerospace and Astronautics Conference (AAAC 2023) will take place in Wuhan, Hubei, China from September 15-17, 2023, where participants will gain detailed insights into the state of the art of aerospace and astronautics, and enjoy the exchange with other enthusiasts from all over the world who are interested in this highly relevant and constantly growing area. The conference is sponsored by Science and Engineering Institute (SCIEI), Huazhong University of Science and Technology, co-sponsored by The Hong Kong Polytechnic University, Nanjing University of Science and Technology, York University, etc.This international conference was over three-days and provided a forum for discussion of aerospace and astronautics. Submitted papers were received and sent for preliminary and peer review conducted by the technical committees. Professional comments are given according to the aspects of originality, innovation, applicability, technical merit, organizing and writing, relevance to conference. After several rounds of review procedure, some excellent papers have been received to get published in the conference proceedings. The proceedings contains a collection of research papers, organized with 6 chapters: aircraft structural design and wing aerodynamic analysis, automation control and visualization technology for flight systems, system design and safety analysis in aerospace engineering, aviation system and engine performance simulation and evaluation, new propulsion technology based on combustion mode, engineering material mechanics analysis and performance simulation and so on.The conference invited four internationally recognised experts in their fields of aerospace and astronautics to deliver keynote and invite speeches, including Prof. Zheng Hong Zhu, York University, Canada; Prof. Chih-Yung Wen, The Hong Kong Polytechnic University, Hong Kong, China; Prof. Yan Wang, Nanjing University of Aeronautics and Astronautics, China; Prof. Lei Shi, Northwestern Polytechnical University, China. Each speaker has delivered the speech more than 30 minutes. In addition, around 50 experts and scholars and listeners from the world’s top research institutes of aerospace technology, including Northwestern Polytechnical University, Nanjing University of Aeronautics and Astronautics, Beihang University, Nanjing University of Science and Technology.We would especially like to thank the organization committees, the members of the program committees and technical committees. They have worked very hard in reviewing papers and making valuable suggestions for the authors to improve their work. We also would like to express our gratitude to the external reviewers, for providing extra helps in the review process, and the authors for contributing their research result to the conference. Without such support a conference cannot maintain quality or add real original contributions to knowledge. It goes without saying, it is core to success, but here we re-iterate that point.On behalf of organizing committees, we would like to express our sincere gratitude to all participants and speakers who contribute to make this event a great success.Conference Organizing Committee AAAC 2023List of Organizing Committees, Statement of Peer Review are available in this Pdf.