PurposeTo investigate the determinants of fraud in medical imaging research. MethodThis study analyzed aggregated survey data on scientific integrity completed by 877 corresponding authors who published in imaging journals in 2021. Multivariate regression analyses were performed to determine the association of scientific fraud with the following variables: survey participants’ age (<18, 18–24, 25–34, 35–44, 45–54, 55–64, or > 65 years), gender (male, female, or other), Corruption Perceptions Index (CPI) of their country of work (linear 0–100 scale), academic degree (medical doctor or other), academic position (none, fellow/resident, instructor/ lecturer, assistant professor, associate professor, full professor, or other), and years of research experience (<5, 5–10, or > 10 years). ResultsThirty-seven survey participants (4.2%) indicated they had committed scientific fraud in the past 5 years, and 223 (25.4%) indicated they had witnessed or suspected scientific fraud by departmental colleagues in the past 5 years. Instructors/lecturers were significantly more likely (P = 0.029) and fellows/residents were nearly significantly more likely (P = 0.050) to have committed scientific fraud, with odds ratios (ORs) of 4.954 and 5.156, respectively (Nagelkerke R2 of 0.114). Survey participants > 65 years of age and survey participants working in less corrupt countries were significantly less likely (P = 0.022 and P = 0.044, respectively) to have witnessed or suspected scientific fraud committed by their departmental colleagues, with ORs of 0.412 and 0.988 (per unit increase in CPI), respectively (Nagelkerke R2 of 0.064). ConclusionsFraud in medical imaging research appears to be more common among junior faculty and in more corrupt countries.