AbstractVariable water quality within buildings is of increasing concern due to public health impacts (e.g., lead, Legionella pneumophila, Naegleria fowleri, disinfection byproducts). Advances in data acquisition and analytics provide the opportunity to monitor real‐time building‐wide water quality variability. Accordingly, the goal of this research was to create a water quality sensor platform including data acquisition, storage, and mining methods able to monitor, and ultimately improve, water quality within buildings. The platform was used to monitor water temperature, pH, conductivity, oxidation–reduction potential, dissolved oxygen, and chlorine using sensors only. Other building data infrastructure, specifically Wi‐Fi logins by occupants, were used to approximate activity rates and associated water use. An advanced machine‐learning technique, gradient boosting machines, predicted the chlorine residuals throughout the building plumbing network better than multivariate linear regression models. Finally, the implications of water quality monitoring on costs, scalability, reliability, human dimensions, regulatory compliance, and future green building designs are considered.