N1-P2 Response Research Articles

The relation between long latency cortical auditory evoked potentials and stuttering severity in stuttering school-age children

BackgroundDisturbances in auditory processing and feedback have been suggested to play a role in the pathogenesis of developmental stuttering. Long latency cortical auditory evoked potentials in response to non-linguistic and linguistic stimuli can be used to investigate these disturbances. There were differences between developmental stuttering patients. However, there is no solid evidence of these differences to date. ObjectiveThis study aims to determine whether there is a statistically significant difference in component P1–N1–P2 of long latency cortical auditory evoked potentials between stuttering school-aged children and non-stuttering children. In addition, the study aims to investigate the relationship between these potentials and objective quantitative measures of stuttering. MethodThe study included two groups, patients and controls, consisting of 40 subjects aged 6–12 years. For the cases group, the severity of stuttering symptoms and P1–N1–P2 responses to a non-linguistic stimulus were evaluated. In addition, the P1–N1–P2 responses of the matched control group were evaluated. ResultsThe P1–N1 responses were similar in both study groups, while P2 response was shorter in the patient group, but the difference was not statistically significant compared to the control group. N1 latency has the only statistically significant correlation with the percentage of repetitions, prolongation, and blocks. The female cases had a decreased, not statistically significant, latency than the male cases group. ConclusionIn contrast to the previous finding, the study revealed a non-statistically significant different P1–N1, a non-statistically significant reduced P2 response to a non-linguistic stimulus, in CWS, in as evidence for basic auditory processing. The study also revealed a significant correlation between N1 latency and proportion of the repetition symptoms.

Right, but not left, posterior superior temporal gyrus is causally involved in vocal feedback control

The posterior superior temporal gyrus (pSTG) has been implicated in the integration auditory feedback and motor system for controlling vocal production. However, the question as to whether and how the pSTG is causally involved in vocal feedback control is currently unclear. To this end, the present study selectively stimulated the left or right pSTG with continuous theta burst stimulation (c-TBS) in healthy participants, then used event-related potentials to investigate neurobehavioral changes in response to altered auditory feedback during vocal pitch regulation. The results showed that, compared to control (vertex) stimulation, c-TBS over the right pSTG led to smaller vocal compensations for pitch perturbations accompanied by smaller cortical N1 and larger P2 responses. Enhanced P2 responses received contributions from the right-lateralized temporal and parietal regions as well as the insula, and were significantly correlated with suppressed vocal compensations. Surprisingly, these effects were not found when comparing c-TBS over the left pSTG with control stimulation. Our findings provide evidence that supports a causal relationship between right, but not left, pSTG and auditory-motor integration for vocal pitch production. This lends support to a right-lateralized contribution of the pSTG in not only detecting vocal feedback errors but also driving motor commands for error correction.

Right, but not left, posterior superior temporal gyrus is causally involved in vocal feedback control

The posterior superior temporal gyrus (pSTG) has been implicated in the integration of auditory feedback and motor system for controlling vocal production. However, the question as to whether and how the pSTG is causally involved in vocal feedback control is currently unclear. To this end, the present study selectively stimulated the left or right pSTG with continuous theta burst stimulation (c-TBS) in healthy participants, then used event-related potentials to investigate neurobehavioral changes in response to altered auditory feedback during vocal pitch regulation. The results showed that, compared to control (vertex) stimulation, c-TBS over the right pSTG led to smaller vocal compensations for pitch perturbations accompanied by smaller cortical N1 and larger P2 responses. Enhanced P2 responses received contributions from the right-lateralized temporal and parietal regions as well as the insula, and were significantly correlated with suppressed vocal compensations. Surprisingly, these effects were not found when comparing c-TBS over the left pSTG with control stimulation. Our findings provide evidence, for the first time, that supports a causal relationship between right, but not left, pSTG and auditory-motor integration for vocal pitch regulation. This lends support to a right-lateralized contribution of the pSTG in not only the bottom-up detection of vocal feedback errors but also the involvement of driving motor commands for error correction in a top-down manner.

Auditory cortical responses to abrupt lateralization shifts do not reflect the activity of hemifield-specific units involved in opponent coding of auditory space

Recent studies show that the classical model based on axonal delay-lines may not explain interaural time difference (ITD) based spatial coding in humans. Instead, a population-code model called “opponent channels model” (OCM) has been suggested. This model comprises two competing channels respectively for the two auditory hemifields, each with a sigmoidal tuning curve. Event-related potentials (ERPs) to ITD-changes are used in some studies to test the predictions of this model by considering the sounds before and after the change as adaptor and probe stimuli, respectively. It is assumed in these studies that the former stimulus causes adaptation of the neurons selective to its side, and that the ERP N1–P2 response to the ITD-change is the specific response of the neurons with selectivity to the side of probe sound. However, these ERP components are known as a global, non-specific acoustic change complex of cortical origin evoked by any change in the auditory environment. It probably does not genuinely reflect the activity of some stimulus-specific neuronal units that have escaped the refractory effect of the preceding adaptor, which means a violation of the crucial assumption in an adaptor-probe paradigm. To assess this viewpoint, we conducted two experiments. In the first one, we recorded ERPs to abrupt lateralization shifts of click trains having various pre- and post-shift ITDs within the physiological range of −600μs to +600μs. Magnitudes of the ERP components P1, N1, and P2 to these ITD-shifts did not comply with the additive behavior of partial probe responses presumed for an adaptor-probe paradigm, casting doubt on the accuracy of testing sensory coding models by using ERPs to abrupt lateralization changes. Findings of the second experiment, involving ERPs to conjoint outwards/transverse shift stimuli also supported this conclusion.

The effect of sensorineural hearing loss on central auditory processing of signals in noise in older adults.

The study aimed to explore the effect of sensorineural hearing loss on the central auditory processing of signals in noise using cortical auditory evoked potentials (CAEPs) in a cohort of older adults. Three groups of individuals participated in the study. Each group included 33 older adults with normal hearing, those with mild hearing loss and those with moderate hearing loss. N1-P2 peaks of CAEPs by speech stimuli in silent conditions and with varying sound pressure levels of background noise were recorded. CAEP latencies, amplitudes and relative changes in CAEP amplitudes as a function of decreasing signal-to-noise ratios (SNR) in three groups were analyzed using the mixed analysis of variance method. There was a significant main effect of SNR on all CAEP components, as well as significant main effects of hearing status on N1 latencies, amplitudes and relative changes in N1 amplitudes. A significant interaction was found between hearing status and SNR for relative changes in N1 amplitudes. The normal hearing group differed from both the mild and moderate hearing loss groups in terms of relative changes in N1 amplitudes at SNR 10 dB. The results showed decreased amplitudes and increased latencies for N1-P2 response as the SNR of CAEP stimuli was lowered. The degree of reduction in the N1 amplitudes of the older people with normal hearing resulting from the increase in the background noise level was greater than those in their sensorineural hearing-impaired counterparts, providing evidence for decreased central inhibition for individuals with age-related hearing loss.

The Onset-Offset N1-P2 Auditory Evoked Response in Individuals With High-Frequency Sensorineural Hearing Loss: Responses to Broadband Noise.

Purpose Clinical use of electrophysiologic measures has been limited to use of brief stimuli to evoke responses. While brief stimuli elicit onset responses in individuals with normal hearing and normal central auditory nervous system (CANS) function, responses represent the integrity of a fraction of the mainly excitatory central auditory neurons. Longer stimuli could provide information regarding excitatory and inhibitory CANS function. Our goal was to measure the onset-offset N1-P2 auditory evoked response in subjects with normal hearing and subjects with moderate high-frequency sensorineural hearing loss (HFSNHL) to determine whether the response can be measured in individuals with moderate HFSNHL and, if so, whether waveform components differ between participant groups. Method Waveforms were obtained from 10 participants with normal hearing and seven participants with HFSNHL aged 40-67 years using 2,000-ms broadband noise stimuli with 40-ms rise-fall times presented at 50 dB SL referenced to stimulus threshold. Amplitudes and latencies were analyzed via repeated-measures analysis of variance (ANOVA). N1 and P2 onset latencies were compared to offset counterparts via repeated-measures ANOVA after subtracting 2,000 ms from the offset latencies to account for stimulus duration. Offset-to-onset trough-to-peak amplitude ratios between groups were compared using a one-way ANOVA. Results Responses were evoked from all participants. There were no differences between participant groups for the waveform components measured. Response × Participant Group interactions were not significant. Offset N1-P2 latencies were significantly shorter than onset counterparts after adjusting for stimulus duration (normal hearing: 43 ms shorter; HFSNHL: 47 ms shorter). Conclusions Onset-offset N1-P2 responses were resistant to moderate HFSNHL. It is likely that the onset was elicited by the presentation of a sound in silence and the offset by the change in stimulus envelope from plateau to fall, suggesting an excitatory onset response and an inhibitory-influenced offset response. Results indicated this protocol can be used to investigate CANS function in individuals with moderate HFSNHL. Supplemental Material https://doi.org/10.23641/asha.14669007.

Varying effect of noise on sound onset and acoustic change evoked auditory cortical N1 responses evoked by a vowel-vowel stimulus

IntroductionAccording to previous studies noise causes prolonged latencies and decreased amplitudes in acoustic change evoked cortical responses. Particularly for a consonant-vowel stimulus, speech shaped noise leads to more pronounced changes on onset evoked response than acoustic change evoked response. Reasoning that this may be related to the spectral characteristics of the stimuli and the noise, in the current study a vowel-vowel stimulus (/ui/) was presented in white noise during cortical response recordings. The hypothesis is that the effect of noise will be higher on acoustic change N1 compared to onset N1 due to the masking effects on formant transitions. MethodsOnset and acoustic change evoked auditory cortical N1-P2 responses were obtained from 21 young adults with normal hearing while presenting 1000 ms /ui/ stimuli in quiet and in white noise at +10 dB and 0 dB signal-to-noise ratio (SNR). ResultsIn the quiet and +10 dB SNR conditions, the N1-P2 responses to both onset and change were present. In the +10 dB SNR condition acoustic change N1-P2 peak-to-peak amplitudes were reduced and N1 latencies were prolonged compared to the quiet condition. Whereas there was not a significant change in onset N1 latencies and N1-P2 peak-to-peak amplitudes in the +10 dB SNR condition. In the 0 dB SNR condition change responses were not observed but onset N1-P2 peak-to-peak amplitudes were significantly lower, and onset N1 latencies were significantly higher compared to the quiet and the 10 dB SNR conditions. Onset and change responses were also compared with each other in each condition. N1 latencies and N1-P2 peak to peak amplitudes of onset and acoustic change were not significantly different in the quiet condition. Whereas at 10 dB SNR, acoustic change N1 latencies were higher and N1-P2 amplitudes were lower than onset latencies and amplitudes. To summarize, presentation of white noise at 10 dB SNR resulted in the reduction of acoustic change evoked N1-P2 peak-to-peak amplitudes and the prolongation of N1 latencies compared to quiet. Same effect on onsets were only observed at 0 dB SNR, where acoustic change N1 was not observed. In the quiet condition, latencies and amplitudes of onsets and changes were not different. Whereas at 10 dB SNR, acoustic change N1 latencies were higher, amplitudes were lower than onset N1. Discussion/conclusionsThe effect of noise was found to be higher on acoustic change evoked N1 response compared to onset N1. This may be related to the spectral characteristics of the utilized noise and the stimuli, possible differences in acoustic features of sound onsets and acoustic changes, or to the possible differences in the mechanisms for detecting acoustic changes and sound onsets. In order to investigate the possible reasons for more pronounced effect of noise on acoustic changes, future work with different vowel-vowel transitions in different noise types is suggested.

Changes in Speech-Related Brain Activity During Adaptation to Electro-Acoustic Hearing.

Objectives: Hearing improves significantly with bimodal provision, i.e., a cochlear implant (CI) at one ear and a hearing aid (HA) at the other, but performance shows a high degree of variability resulting in substantial uncertainty about the performance that can be expected by the individual CI user. The objective of this study was to explore how auditory event-related potentials (AERPs) of bimodal listeners in response to spoken words approximate the electrophysiological response of normal hearing (NH) listeners.Study Design: Explorative prospective analysis during the first 6 months of bimodal listening using a within-subject repeated measures design.Setting: Academic tertiary care center.Participants: Twenty-seven adult participants with bilateral sensorineural hearing loss who received a HiRes 90K CI and continued use of a HA at the non-implanted ear. Age-matched NH listeners served as controls.Intervention: Cochlear implantation.Main Outcome Measures: Obligatory auditory evoked potentials N1 and P2, and the event-related N2 potential in response to monosyllabic words and their reversed sound traces before, as well as 3 and 6 months post-implantation. The task required word/non-word classification. Stimuli were presented within speech-modulated noise. Loudness of word/non-word signals was adjusted individually to achieve the same intelligibility across groups and assessments.Results: Intelligibility improved significantly with bimodal hearing, and the N1–P2 response approximated the morphology seen in NH with enhanced and earlier responses to the words compared to their reversals. For bimodal listeners, a prominent negative deflection was present between 370 and 570 ms post stimulus onset (N2), irrespective of stimulus type. This was absent for NH controls; hence, this response did not approximate the NH response during the study interval. N2 source localization evidenced extended activation of general cognitive areas in frontal and prefrontal brain areas in the CI group.Conclusions: Prolonged and spatially extended processing in bimodal CI users suggests employment of additional auditory–cognitive mechanisms during speech processing. This does not reduce within 6 months of bimodal experience and may be a correlate of the enhanced listening effort described by CI listeners.

Long-latency event-related responses to vowels: N1-P2 decomposition by two-step principal component analysis

The N1-P2 complex of the auditory event-related potential (ERP) has been used to examine neural activity associated with speech sound perception. Since it is thought to reflect multiple generator processes, its functional significance is difficult to infer. In the present study, a temporospatial principal component analysis (PCA) was used to decompose the N1-P2 response into latent factors underlying covariance patterns in ERP data recorded during passive listening to pairs of successive vowels. In each trial, one of six sounds drawn from an /i/−/e/ vowel continuum was followed either by an identical sound, a different token of the same vowel category, or a token from the other category. Responses were examined as to how they were modulated by within- and across-category vowel differences and by adaptation (repetition suppression) effects. Five PCA factors were identified as corresponding to three well-known N1 subcomponents and two P2 subcomponents. Results added evidence that the N1 peak reflects both generators that are sensitive to spectral information and generators that are not. For later latency ranges, different patterns of sensitivity to vowel quality were found, including category-related effects. Particularly, a subcomponent identified as the Tb wave showed release from adaptation in response to an /i/ followed by an /e/ sound. A P2 subcomponent varied linearly with spectral shape along the vowel continuum, while the other was stronger the closer the vowel was to the category boundary, suggesting separate processing of continuous and category-related information. Thus, the PCA-based decomposition of the N1-P2 complex was functionally meaningful, revealing distinct underlying processes at work during speech sound perception.

Event-related potentials to single-cycle binaural beats and diotic amplitude modulation of a tone.

When two tones with slightly different frequencies are dichotically presented, binaural beats (BBs) are experienced. BBs resulting from the cycling change in interaural phase difference elicit electroencephalographic responses. Because they repeat at short periods, allowing poor recovery of the cortical responses, these steady-state responses have small amplitudes, and their various wave components intermingle and might mask each other. Using single-cycle BBs separated by relatively long inter-onset intervals would be a solution, but introducing a transient interaural frequency shift requires response subtraction which may not be acceptable for non-additive brain responses. The proposed stimulation method employs transient and monaurally subthreshold frequency shifts in opposite directions in the two ears to produce single-cycle BBs of a 250Hz tone. These shifts are perceived as distinct BBs when presented dichotically, but remain subthreshold when presented monotically. Therefore, no frequency-shift response is elicited, and the specific BB response is obtained with no need for waveform subtraction. We recorded from 19 normal hearing participants the event-related potentials (ERPs) to single-cycle BBs and also to temporary diotic amplitude modulation (AM) with matched perceptual salience. The ERPs to single-cycle BBs presented at 2s inter-onset intervals had N1-P2 responses with up to seven times larger amplitudes than the conventional steady-state BB responses in the literature. Significant differences were found between the scalp potential distributions of the N1 responses to BB and AM stimuli, suggesting that the cortical sites, where envelope-based level processing and temporal fine structure-based spatial processing of the stimulus take place, are not totally overlapped.

Effects of directional sound processing and listener's motivation on EEG responses to continuous noisy speech: Do normal-hearing and aided hearing-impaired listeners differ?

ObjectiveIt has been suggested that the next major advancement in hearing aid (HA) technology needs to include cognitive feedback from the user to control HA functionality. In order to enable automatic brainwave-steered HA adjustments, attentional processes underlying speech-in-noise perception in aided hearing-impaired individuals need to be better understood. Here, we addressed the influence of two important factors for the listening performance of HA users – hearing aid processing and motivation – by analysing ongoing neural responses during long-term listening to continuous noisy speech. MethodsSixteen normal-hearing (NH) and 15 linearly aided hearing-impaired (aHI) participants listened to an audiobook recording embedded in realistic speech babble noise at individually adjusted signal-to-noise ratios (SNRs). A HA simulator was used for simulating a directional microphone setting as well as for providing individual amplification. To assess listening performance behaviourally, participants answered questions about the contents of the audiobook. We manipulated (1) the participants' motivation by offering a monetary reward for good listening performance in one half of the measurements and (2) the SNR by engaging/disengaging the directional microphone setting. During the speech-in-noise task, electroencephalography (EEG) signals were recorded using wireless, mobile hardware. EEG correlates of listening performance were investigated using EEG impulse responses, as estimated using the cross-correlation between the recorded EEG signal and the temporal envelope of the audiobook at the output of the HA simulator. ResultsAt the behavioural level, we observed better performance for the NH listeners than for the aHI listeners. Furthermore, the directional microphone setting led to better performance for both participant groups, and when the directional microphone setting was disengaged motivation also improved the performance of the aHI participants. Analysis of the EEG impulse responses showed faster N1P2 responses for both groups and larger N2 peak amplitudes for the aHI group when the directional microphone setting was activated, but no physiological correlates of motivation. SignificanceThe results of this study indicate that motivation plays an important role for speech understanding in noise. In terms of neuro-steered HAs, our results suggest that the latency of attentional processes is influenced by HA-induced stimulus changes, which can potentially be used for inferring benefit from noise suppression processing automatically. Further research is necessary to identify the neural correlates of motivation as an exclusive top-down process and to combine such features with HA-driven ones for online HA adjustments.

The Sense of Sounds: Brain Responses to Phonotactic Frequency, Phonological Grammar and Lexical Meaning.

Two outstanding questions in spoken-language comprehension concern (1) the interplay of phonological grammar (legal vs. illegal sound sequences), phonotactic frequency (high- vs. low-frequency sound sequences) and lexicality (words vs. other sound sequences) in a meaningful context, and (2) how the properties of phonological sequences determine their inclusion or exclusion from lexical-semantic processing. In the present study, we used a picture-sound priming paradigm to examine the ERP responses of adult listeners to grammatically illegal sound sequences, to grammatically legal sound sequences (pseudowords) with low- vs. high-frequency, and to real words that were either congruent or incongruent to the picture context. Results showed less negative N1-P2 responses for illegal sequences and low-frequency pseudowords (with differences in topography), but not high-frequency ones. Low-frequency pseudowords also showed an increased P3 component. However, just like illegal sequences, neither low- nor high-frequency pseudowords differed from congruent words in the N400. Thus, phonotactic frequency had an impact before, but not during lexical-semantic processing. Our results also suggest that phonological grammar, phonotactic frequency and lexicality may follow each other in this order during word processing.

Differential effects of hearing loss on neural and behavioral measures of speech perception in noise

Understanding speech in background noise is difficult for many listeners, and those with hearing impairment tend to show considerable variability in performance. Event-related potentials (ERPs) and associated cortical oscillations are useful for examining neural responses to speech in various listening conditions and may represent neurophysiological markers of auditory perception. The present study examined the effects of hearing impairment on the neural coding and perception of speech in noise in a group of adult listeners with varying degrees of sensorineural hearing loss. This work was also designed to determine whether cortical ERPs and oscillatory rhythms in various frequency bands can predict the effects of hearing impairment on sentence recognition in noise. Passive N1-P2 and MMN responses were elicited with a double-oddball paradigm containing a consonant and vowel change in background noise. Speech perception was evaluated using phoneme discrimination and sentence recognition in noise tasks. Anal...

Effect of musical training on EEG measures of spectro-temporal processing

Recent studies show that musical training enhances auditory processing abilities such as sensitivity to temporal fine structure and narrowband frequency resolution. Little is known about the effect of musical training on broadband spectro-temporal processing using rippled noise. This study evaluated whether musician enhancement in frequency resolution can be generalized to broadband spectro-temporal resolution using electrophysiological measures. We tested the hypothesis that musicians have enhanced broadband spectral resolution abilities compared to non-musicians. Spectral processing was measured using P1 N1 P2 responses to spectro-temporally modulated rippled noise. The test stimulus was spectro-temporally modulation wideband (4 octaves) rippled noise from 350 to 5600 Hz. EEG recordings were made using a 32-channel standard 10/20 configuration BioSemi system with a sampling rate of 4 kHz. For each condition, 1000 repetitions of the test stimuli were presented at 100% modulation with 2 Hz temporal modulation via electrically shielded ER-3A earphones, using a passive listening paradigm. The amplitude and latency of the P1-N1-P2 components were measured to determine whether musicians had better sensitivity to spectro-temporal modulation compared to age-matched non-musicians. Results to date show slight musician enhancement in spectral processing. The clinical implications of these findings for auditory-rehabilitation will be discussed.

Infant Cortical Auditory Evoked Potentials to Lateralized Noise Shifts Produced by Changes in Interaural Time Difference.

Newborns reliably orient to sound location soon after birth; by age 1 month this orienting disappears until after age 4 months. It has been suggested that orienting by the newborn reflects subcortical-mediated reflexes, which are suppressed by age 1 month; reappearance of orienting then occurs after age 4 months with maturation of cortical mechanisms of sound localization. In the present study, we assess auditory lateralization in young infants (and adults) by recording slow cortical auditory evoked potentials to lateralization shifts in dichotic noise produced by changes in interaural time difference (ITD). Fifteen normal infants aged under 4 months (mean = 10.7 weeks) had cortical auditory evoked potentials assessed in response to (1) diotic "onset" noise bursts (0 msec ITD) and (2) shifts in continuous lateralized noise (75 dB SPL) produced by ITD shifts of 0.5, 0.8, 1, 2, 4, and 8 msec. Shifts alternated between ears occurred every 2 sec. Stimuli were presented using insert earphones; infants slept during recordings. For comparison, similar recordings were obtained in 11 normal-hearing, awake, adults. Additionally, "control" recordings to the ITD-shift stimuli presented to only one ear were obtained in the adults. Similar to previous research, adults showed clear N1-P2 responses to the lateralization shifts (ITD 0.5 to 2.0 msec). Responses decreased for longer ITD shifts, with no adult responses to the 8-msec ITD shift. N1 latencies to ITD-shift stimuli were 28 to 34 msec longer than to the onset stimuli. No responses were seen in the control conditions when ITD-shift stimuli were presented to only one ear (confirming the binaural nature of the ITD-shift responses). All infants showed P2 responses to one or more of the ITD-shift stimuli up to ±1 msec; compared with adults, infants showed larger amplitude decreases and fewer responses to longer ITD-shift stimuli. As was seen with the adult responses, infant response (P2) latencies to ITD shifts were longer compared with their responses to the onset stimuli; however, these increases, 32 to 78 msec, were significantly longer than those seen in the adults. Young infants (even as young as 5 weeks) show clear evidence of auditory cortical responsivity to lateralization shifts produced by changes in the ITD of continuous noise, indicating that they have the capacity to process binaural ITD timing cues well before the age of 4 months. Further research is required to determine whether the larger latency increase in infants for ITD-shift stimuli (relative to the onset stimuli) and the greater effect of longer ITD shifts on response presence and amplitude in infants reflects immaturity of lateralization processing and/or reduced responses recorded during sleep. Slow cortical auditory evoked potentials elicited to lateralization shifts in dichotic noise provide a method to investigate binaural hearing processes in young children with normal or impaired hearing.

Summary of the N1-P2 Cortical Auditory Evoked Potential to Estimate the Auditory Threshold in Adults.

This article introduces the cortical auditory evoked potential (CAEP) and describes the use of the N1-P2 response complex as an objective predictor of hearing threshold in adults and older children. The generators of the CAEP are discussed together with issues of maturation, subject factors, and stimuli and recording parameters for use in the clinic. The basic methods for response identification are outlined and suggestions are made for determining the CAEP threshold. Clinical applications are introduced and the accuracy of the CAEP as an estimator of hearing threshold is given. Finally, a case study provides an example of the technique in the context of medicolegal assessment.

Effects of background noise on inter-trial phase coherence and auditory N1–P2 responses to speech stimuli

This study investigated the effects of a speech-babble background noise on inter-trial phase coherence (ITPC, also referred to as phase locking value (PLV)) and auditory event-related responses (AERP) to speech sounds. Specifically, we analyzed EEG data from 11 normal hearing subjects to examine whether ITPC can predict noise-induced variations in the obligatory N1–P2 complex response. N1–P2 amplitude and latency data were obtained for the /bu/syllable in quiet and noise listening conditions. ITPC data in delta, theta, and alpha frequency bands were calculated for the N1–P2 responses in the two passive listening conditions. Consistent with previous studies, background noise produced significant amplitude reduction and latency increase in N1 and P2, which were accompanied by significant ITPC decreases in all the three frequency bands. Correlation analyses further revealed that variations in ITPC were able to predict the amplitude and latency variations in N1–P2. The results suggest that trial-by-trial analysis of cortical neural synchrony is a valuable tool in understanding the modulatory effects of background noise on AERP measures.

Cortical auditory evoked potentials as an objective measure of behavioral thresholds in cochlear implant users

The aim of this study was to assess the suitability of using cortical auditory evoked potentials (CAEPs) as an objective tool for predicting behavioral hearing thresholds in cochlear implant (CI) users. Nine experienced adult CI users of Cochlear™ devices participated. Behavioral thresholds were measured in CI users across apical, mid and basal electrodes. CAEPs were measured for the same stimuli (50 ms pulse trains of 900-pps rate) at a range of input levels across the individual's psychophysical dynamic range (DR). Amplitude growth functions using global field power (GFP) were plotted, and from this the CAEP thresholds were extrapolated and compared to the behavioral thresholds. Increased amplitude and decreased latency of the N1–P2 response was seen with increasing input level. A strong correlation was found between CAEP and behavioral thresholds (r = 0.93), implying that the cortical response may be more useful as an objective programming tool for cochlear implants than the auditory nerve response.

Auditory N1-P2 Cortical Event Related Potentials in Auditory Neuropathy Spectrum Disorder Patients

OBJECTIVE: The purpose of this study was to determine whether a group of patients with auditory neuropathy have abnormal changes in auditory N1-P2 and to analyze the results in those patients and compare them with matched group of normal subjects. MATERIALS and METHODS: Cortical auditory evoked potentials were obtained from nine female and seven male patients with auditory neuropathy, ranging in age from 19 to 48 years. The control group comprised 15 (9 males and 6 females) age-matched, normally hearing adults. Cortical auditory evoked potentials were recorded in both groups. Audiological assessments were performed in both groups, which included pure tone audiometry, speech audiometry, tympanometry, acoustic reflex, distortion products otoacoustic emissions, as well as auditory brainstem potential testing. RESULTS: N1-P2 amplitudes were reduced and latencies were prolonged in the study group, and these parameters were found to be statistically significant when compared to normal subjects (p<0.05). CONCLUSION: The neurophysiologic measures of auditory processing-i.e., N1-P2 response to tonal frequency stimuli-in auditory neuropathy spectrum disorder patients are found to be different. Hence, arguing a doubt on the affection of hypothesize origin of the N1-P2 potential in ANSD

Electrophysiological gap detection thresholds: effects of age and comparison with a behavioral measure.

Temporal processing ability has been linked to speech understanding ability and older adults often complain of difficulty understanding speech in difficult listening situations. Temporal processing can be evaluated using gap detection procedures. There is some research showing that gap detection can be evaluated using an electrophysiological procedure. However, there is currently no research establishing gap detection threshold using the N1-P2 response. The purposes of the current study were to 1) determine gap detection thresholds in younger and older normal-hearing adults using an electrophysiological measure, 2) compare the electrophysiological gap detection threshold and behavioral gap detection threshold within each group, and 3) investigate the effect of age on each gap detection measure. This study utilized an older adult group and younger adult group to compare performance on an electrophysiological and behavioral gap detection procedure. The subjects in this study were 11 younger, normal-hearing adults (mean = 22 yrs) and 11 older, normal-hearing adults (mean = 64.36 yrs). All subjects completed an adaptive behavioral gap detection procedure in order to determine their behavioral gap detection threshold (BGDT). Subjects also completed an electrophysiologic gap detection procedure to determine their electrophysiologic gap detection threshold (EGDT). Older adults demonstrated significantly larger gap detection thresholds than the younger adults. However, EGDT and BGDT were not significantly different in either group. The mean difference between EGDT and BGDT for all subjects was 0.43 msec. Older adults show poorer gap detection ability when compared to younger adults. However, this study shows that gap detection thresholds can be measured using evoked potential recordings and yield results similar to a behavioral measure.