With the massive spike in the use of Online Social Network Sites (OSNSs) platforms such as Web 2.0, microblogs services and online blogs, etc., valuable information in the form of sentiment, thoughts, opinions, as well as epidemic outbreaks, etc. are transferred. With the OSNSs being widely accessible, this work aims at proposing a novel approach for disease (dengue or flu) detection based on social media posts. For this purpose, an automated approach is designed with the help of LSTM (Long Short Term Memory) and word embedding techniques. Then the performance of the proposed approach is validated using a set of standard evaluation matrices. In addition, the effectiveness of the selected models is evaluated with performance measurement techniques. The accuracy of the proposed research approach is evaluated using two word embedding techniques; Word2Vec with Skip-gram (SG) and Word2Vec with Continuous-bag-of-words (CBOW). Based on the results conducted in this paper the LSTM Word2Vec with CBOW achieved better results compared to LSTM with Word2Vec SG features embedding technique. Our findings prove that the proposed method yields 94% accuracy compared to state-of-the-art approaches. Consequently, LSTM performed better than other leading methods in the detection of disease-infected people in tweets. In the end, spatial analysis is performed to identify the disease infected region.