This study aims to develop learning modules for science subjects to determine the feasibility, practicality, and effectiveness of using science learning modules for class IX in junior high school. This research is a type of research and development conducted at SMP Negeri 1 Paringin. The selected development model is the ADDIE model. The object of research is the development of science learning modules on the topic of biotechnology. Data collection using questionnaires and questions (pretest-posttest). The result of this research is the development of science learning modules. The modules that have been developed are declared good, based on material experts with an average score of 3.64 or 91.08 with the criteria "Very Valid", assessments from media experts with an average of 3.79 or 94.83% with the criteria "Very Valid". Modules that have been assessed as good are then tested for their effectiveness on students. Based on the results of research conducted by learning with the Science module that the effectiveness of student learning has increased in class IX B which can be seen in the N-Gain result of 0.73 with the "High" criterion. According to the data on student responses to the Science module as a whole it was stated "Very Practical", this can be seen from the results of the average score from the respondent's trial of 3.37 with a percentage of 84.21%. Based on the research results, the product in the form of a science learning module on the topic of biotechnology for differentiation learning is declared valid, effective, and practical and can be used as a support for learning in science lessons on the topic of biotechnology.
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