Event Abstract Back to Event Immune manifestations in myelodysplasia. A prospective 4 year study. Cristina Belizna1*, Alaa Ghali1, Daniel Henrion1 and Norbert Ifrah2 1 CHU Angers, Internal Medicine, France 2 CHU Angers, Hematology, France The presence of systemic and/or immune manifestations in myelodysplasia is classical, even thought rarely presenting as initial clinical event. Purpose We present a prospective study (2009-2012) with systemic and/or immune manifestations dominating the clinical presentation. Patients et methods 341 patients with a formal diagnosis of myelodysplasia were followed-up for 4 years. Among them 36 developped systemic and/or immune manifestations during the follw-up period (2009-2012). The clinical picture in these cases consisted in transient fever, not related to infections (25%), arthralgia or arthritis (17%), and especially cutaneous (purpura 35%, nodular 15%, papular 8%, and necrotic lesions 5%) related to cutaneous lymphocytary and/or leucocytoclasic vasculitis. Lung symptoms were occasional (2% of cases), the same as renal manifestations (3% of cases). Even though infrequently, some rare cases of systemic vasculitis have been reported in our series (one cas of Wegener granulomatosis, two cas of microscopic polyangeitis et one cas of Churg-Strauss syndrome). Immune anomalies were recorded in 25% of the cases (antinuclear antibodies 20%, ANCA 10%, rheumatoid factor 12%). A corticosteroid treatment was efficient in 90% of the cases. Discussion and conclusion The association between myelodysplasic syndromes with systemic and immune manifestations seems to not be occasional and suggest the eventuality of a potential common primary immune disorder. Keywords: Vasculitis, Leukocytoclastic, Cutaneous, myelodysplasia, Vascular Diseases, Vasculitis, myelodysplastic syndrome (MDS) Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Belizna C, Ghali A, Henrion D and Ifrah N (2013). Immune manifestations in myelodysplasia. A prospective 4 year study. . Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00509 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Apr 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. Cristina Belizna, CHU Angers, Internal Medicine, ANGERS, 49000, France, crbelizna@chu-angers.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Cristina Belizna Alaa Ghali Daniel Henrion Norbert Ifrah Google Cristina Belizna Alaa Ghali Daniel Henrion Norbert Ifrah Google Scholar Cristina Belizna Alaa Ghali Daniel Henrion Norbert Ifrah PubMed Cristina Belizna Alaa Ghali Daniel Henrion Norbert Ifrah Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.