Treatment of interstitial lung disease associated with connective tissue disease (CTD-ILD) is an area of high unmet medical need. A 1-year cyclophosphamide (CYC) treatment regimen improved scleroderma (SSc)-associated ILD (SSc-ILD) in a randomized placebo-controlled trial1, but failed to sustain improvement after 2 years2. A second multicenter trial of 6 months of CYC for SSc-ILD did not demonstrate efficacy3. Even given a possible modest benefit, CYC is undesirable for chronic or repetitive use due to its toxicity, making the ascertainment of other treatments for CTD-ILD a high priority. In this issue of The Journal , Fischer, et al 4 report apparent broad utility of mycophenolate mofetil (MMF) in the treatment of CTD-ILD. MMF has been gaining acceptance for treatment of CTD-ILD based on earlier small studies, including those of the authors5 and others6,7,8,9,10,11 and a recent metaanalysis12. This body of work suggests that MMF can confer stability or modest improvement in pulmonary function tests (PFT). The Scleroderma Lung Study-II (SLS-II) [a US National Institutes of Health (NIH)-sponsored randomized, blinded comparison of 2-year treatment with MMF versus 1-year treatment with CYC, plus 1-year followup for SSc-ILD] completed enrollment of about 140 subjects (http://clinicaltrials.gov/show/NCT00883129). It will be 2 more years, however, before analysis of SLS-II is completed. The Fischer, et al study, although neither randomized nor blinded, has several important strengths. First, it comprises the largest published groups of MMF-treated patients with SSc-ILD as well as other CTD-ILD. Second, there appears to be broad benefit of MMF, irrespective of the specific CTD diagnosis, or of ILD histologic subtype. The study benefits from relatively uniform dosing of MMF at 2 grams per day … Address correspondence to Dr. Molitor; E-mail: jmolitor{at}umn.edu