Cowpea (Vigna unguiculata L. walp) is one of the most important leguminous crops that are widely grown throughout the tropics. The aim of the study is to evaluate the combination of two botanical powders and a synthetic insecticide in the control of cowpea weevil (Callosobruchus maculatus) on stored cowpea grain. The botanical powders were admixed with the cowpea grain at a combination of 3:7, 7:3 and 5:5 per 50g of beans while the primiphos methyl powder was admixed at 0.25g per 50g of cowpea. In the control, no treatment was used. The experimental design adopted for the experiment was Complete Randomized Design (CRD) and each treatment was replicated four times for each experiment. Twenty (20) adults of C. maculatus unsexed (taken from stock culture kept in the laboratory) were introduced into each vial including the control and were covered with muslin cloth held tightly in place with rubber band to prevent the weevils from escaping. The experiments were monitored for 72 hours. The results showed that the plant powders and primiphos methyl powder were good grain protectants. The highest mortality recorded was in primiphos methyl powder (78) followed by the combination of Azadirachta indica and Zingiber officinale powder at the ratio of 5:5 (76), 7:3 (68) while the least was 3:7 which recorded 62. The mean mortality of C. maculatus caused by primiphos methyl powder (6.50), was significantly (P<0.05) different from the untreated control (0.00), but was not statistically different from the combination of Azadirachta indica and Zingiber officinale in the ratio of 5 to 5, but the combinations of A. indica and Z. officinale in the ratio of 3:7 and 7:3 were significantly different. The study suggests that botanicals should be incorporated into grain protection as alternatives to chemical insecticides in the control of C. maculatus in cowpea grain during storage.