Music Sessions Research Articles

Music compensates for altered gene expression in age-related cognitive disorders

Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes of ACD patients and healthy controls, pre-post a music session (n = 60), and main genes/pathways were compared to those dysregulated in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) as revealed by a multi-cohort study (n = 1269 MCI/AD and controls). Music was associated with 2.3 times more whole-genome gene expression, particularly on neurodegeneration-related genes, in ACD than in controls. Co-expressed gene-modules and pathways analysis demonstrated that music impacted autophagy, vesicle and endosome organization, biological processes commonly dysregulated in MCI/AD. Notably, the data indicated a strong negative correlation between musically-modified genes/pathways in ACD and those dysregulated in MCI/AD. These findings highlight the compensatory effect of music on genes/biological processes affected in MCI/AD, providing insights into the molecular mechanisms underlying the benefits of music on these disorders.

Spark Care+: Personalized Music Therapy for Relaxation and Energizing Using a Mobile and AI Approach

Worldwide 1 in 8 people live with a mental illness (WHO, 2022). Music releases neurotransmitters, including dopamine, but without the side effects of medications (Schriewer, Bulaj, 2016). This study aims to test the effectiveness of personalized music therapy to relax or energize participants using a machine learning model (ML) connected to a mobile app created by the researcher, using information from the Galvanic Skin Response and Heart Rate sensors. In order to provide a more personalized therapy experience, an option to change pieces was given if biometrics did not align with session goals after 15 seconds. Sixty sessions of 15 minutes each took place, 25 at home and 35 in school settings. Participants had higher variance in the energizing session compared to the relaxation. However, significantly more participants across both sessions had a decrease in biometrics rather than an increase or no change, indicating that both music sessions helped the participants relieve stress. The number of interventions for all pieces statistically decreased while the average ratings from 1-5 statistically increased from the first to the last piece indicating the effectiveness of the machine learning model for both sessions selecting the pieces that fit the participant’s preferences while helping to lower stress and obtain the session’s optimal physiological and emotional responses. The data suggests that the personalized music selection for both relaxation and energizing by the Spark Care+ app can lead to participants feeling more relaxed or energized depending on their musical choices.

Creative aging in virtual spaces: using museum content and music therapy to explore cultural diversity

IntroductionDuring the pandemic, many creative aging programs stopped being delivered in person, and practitioners turned to various virtual platforms to deliver content for older adults to maintain their cognitive, physical, and psychosocial well-being. Collaborators from a university-based music therapy program and a global music museum developed asynchronous virtual programs, one for wellness populations and another for memory care settings. Content was developed and delivered by the paper’s principal investigators in collaboration with the museum’s curatorial team and an upper division music therapy class composed of juniors and first-year graduate equivalency students (n = 21). The asynchronous program included museum gallery content and music therapy interventions of singing, movement, and/or instrument playing based on highlighted geographic regions. The purpose of the study was to explore older adults’ experiences when participating in the program.MethodsFifty-six older adults from three post-acute care facilities (two skilled nursing facilities and one assisted living center) served as participants. Older adult participants were categorized as cognitively healthy (n = 27) or those diagnosed with dementia (n = 29) and attended five music sessions over 8 weeks, ranging from 30 to 60 min in length. A within-subject repeated measures design was used to investigate the impact of the creative aging program on older adults’ psychosocial well-being and engagement behaviors. Psychosocial well-being for cognitively healthy older adults were measured with the Multicultural Quality of Life Index, Engagement in Meaningful Activity Survey, and the PROMIS Social Isolation Short Form-4a. Psychosocial well-being for older adults with memory loss was measured with the Quality of Life in Late-Stage Dementia tool.ResultsCognitively healthy older adults showed an increase in psychological/emotional wellness after participating in the program, while older adults with memory loss appeared less irritable and physically uncomfortable and seemed to enjoy interacting with others more. Surprisingly, the cognitively healthy older adults also showed an increase in social isolation between the start and end of the program, which may not be related to the intervention, but to the fact that all three sites had COVID outbreaks during the study and had to pause their group activities programming and residents were required to stay in their rooms. Additionally, the music interventions fostered engagement behaviors of interest (facial expression, posture), and response (body movement, eye contact, and musical interaction with the leaders in the videos) for both groups of older adults. Instrument interventions were most engaging for cognitively healthy older adults. Singing interventions were most engaging for older adults with dementia, whereas movement interventions were less engaging for older adults with dementia.DiscussionFindings suggest that creative aging virtual programs can be delivered in asynchronous settings to enhance older adults’ well-being and foster engagement. Additionally, virtual programming may be used to augment ongoing programming or used to reach older adults when distance is a factor to enhance older adults’ well-being.

Enabling Musical, Pedagogical, and Social Continuities through “Participation” in Mary O’s Virtual Irish Traditional Music Session

This study utilises virtual ethnography to examine “Mary O’s Virtual Session,” a weekly Irish traditional music session that, in response to the COVID-19 pandemic, migrated online using YouTube Live—a platform key to the study for facilitating interactive, synchronous learning. Drawing on theoretical frameworks by scholars including Turino (2008) and Jenkins (2006), this research interrogates “participation” and examines the transformative potential of this virtual session as a locus for music transmission, challenging traditional practices’ reliance on co-location. Despite limitations imposed by the virtual environment, the research posits that this adaptation cultivated a crucial “nexus of learning,” facilitating substantial pedagogical, musical, and social continuities for music learners amidst the pandemic. The findings provide valuable insights for music educators in the digital age, suggesting the importance of media convergence in developing supports to enable learner participation in virtual spaces. This study underscores the ongoing evolution and specialisation of online teaching in music education.

Functional reorganization of the brain in distinct frequency bands during eyes-open meditation

Meditation is a self-regulatory process practiced primarily to reduce stress, manage emotions and mental health. The objective of this work is to study the information exchange between electrodes within and across the hemispheres during meditation using functional connectivity (FC) measures. We investigate the changes in the coherence between EEG electrode pairs during the meditation with open eyes practiced by long-term Brahmakumaris Rajyoga meditators and during listening to music by controls as the comparable task. FC derived from coherency, pairwise phase consistency (PPC) is used to study the changes in intra and interhemispheric coherence. Integrating connectivity (IC) derived from node degree strength has also been analyzed. Meditators show increased PPC in higher theta and alpha bands both within and across hemispheres. However, the control subjects with no knowledge of meditation show no change in theta band during the music session. Further, during baseline conditions, higher interhemispheric anterior to posterior IC is found in meditators in higher beta and slow gamma bands than controls. Distinct patterns of changes are observed with the PPC and IC measures in different frequency bands during meditation in the meditators and music-listening session in the control subjects indicating varied information processing between the right and left hemispheres. Increased IC is found between the frontal electrodes implying increased self-awareness in meditators. The PPC between the occipital electrodes in meditators is less than the controls in baseline condition indicating a possible modified visual information processing in Rajyoga meditators due to the long-term practice of meditation with open eyes. Overall, the changes in PPC and associated IC indicate increased functional integration during meditation supporting the hypothesis of communication through coherence and cortical integration theory during the non-ordinary state of consciousness induced by meditation.

Home-based family caregiver-delivered music and reading interventions for people living with dementia (HOMESIDE trial): an international randomised controlled trial

Music interventions provided by qualified therapists within residential aged care are effective at attenuating behavioural and psychological symptoms (BPSD) of people with dementia (PwD). The impact of music interventions on dementia symptom management when provided by family caregivers is unclear. We implemented a community-based, large, pragmatic, international, superiority, single-masked randomised controlled trial to evaluate if caregiver-delivered music was superior to usual care alone (UC) on reducing BPSD of PwD measured by the Neuropsychiatric Inventory-Questionnaire (NPI-Q). The study included an active control (reading). People with dementia (NPI-Q score ≥6) and their caregiver (dyads) from one of five countries were randomly allocated to caregiver-delivered music, reading, or UC with a 1:1:1 allocation stratified by site. Caregivers received three online protocolised music or reading training sessions delivered by therapists and were recommended to provide five 30-min reading or music activities per week (minimum twice weekly) over 90-days. The NPI-Q severity assessment of PwD was completed online by masked assessors at baseline, 90- (primary) and 180-days post-randomisation and analysed on an intention-to-treat basis using a likelihood-based longitudinal data analysis model. ACTRN12618001799246; ClinicalTrials.govNCT03907748. Between 27th November 2019 and 7th July 2022, we randomised 432 eligible of 805 screened dyads (music n=143, reading n=144, UC n=145). There was no statistical or clinically important difference in the change from baseline BPSD between caregiver-delivered music (-0.15, 95% CI-1.41 to 1.10, p=0.81) or reading (-1.12, 95% CI-2.38 to 0.14, p=0.082) and UC alone at 90-days. No related adverse events occurred. Our findings suggested that music interventions and reading interventions delivered by trained caregivers in community contexts do not decrease enduring BPSD symptoms. Our funding was provided by National Health and Medical Research Council, Australia; The Research Council of Norway; Federal Ministry of Education and Research, Germany; National Centre for Research and Development, Poland; Alzheimer's Society, UK, as part of the Joint Programme for Neurodegenerative Diseases consortia scheme.

Live bedside music for hospitalized older adults: A qualitative descriptive interview study.

Hospitalization may have a major impact on older patients as it is often a period of psychosocial vulnerability. Music is one of the most described art forms used in healthcare. Applied in clinical settings, it can affect a patients' emotional and psychosocial well-being. Incorporating a wider perspective of health promotion that aims to advance not only physical health, but a patients' overall well-being, is part of a person-centred approach to care. We developed an innovative participatory music practice in which professional musicians and music therapists visited patients at their bedside for 10-15 min in a Dutch and Austrian hospital. This qualitative study explores the added value of live bedside music practice for older hospitalized patients in Austria and the Netherlands. Semi-structured interviews were conducted between October 2020 and February 2022 with 23 hospitalized patients aged ≥60 years. Due to the COVID-19 pandemic, the music sessions in Austria were facilitated by establishing a live connection between musicians and patients using a tablet. Data were transcribed verbatim and performed qualitative content analysis following the steps of thematic analysis. The COnsolidated criteria for REporting Qualitative research (COREQ) checklist was applied to report data collection, analysis and results. Four themes emerged from the data analysis. Participants described the perceived influences of live bedside music in terms of (1) emotional release, (2) positive distraction, (3) alterations in contact and (4) shared humanity. Overall, participants positively valued the live bedside music practice and expressed a desire for its continuation. This study explores the experiences and the added value of live bedside music for older hospitalized patients. By facilitating distraction and emotional release and enhancing nurse-patient interactions, live bedside music can significantly improve hospital experiences for older patients. Results reveal that live bedside music provides a positive patient experience and can be part of integrative and holistic care for hospitalized older patients. Live bedside music can attend to the emotional needs of older patients which are often under addressed in clinical settings but are crucial for enhancing their well-being.

Joint music sessions, parents, and their lesbian and gay young adult children: Effectiveness on the ‘coming out’ process, relationships, and wellbeing

‘Coming out’ can be a psychologically challenging event and parental acceptance is often a prime concern. This article reports a study on the impact of music sessions delivered online and jointly for dyads of parents and their young adult children with lesbian and gay sexual identities in improving parental acceptance of sexual orientation, parent adult relationships, and wellbeing, compared to a waitlist control group. The music sessions were effective (Hedges’ g= −0.91 to 0.67; p < 0.05) and participants with higher formal education (postgraduate or professional degree), and whose intervention compliance was higher (>50% music sessions attended and homework sessions completed), were reported higher post-test scores on perceived parental support on sexual orientation, positive dimensions of parent adult relationships (warmth or affection, thoughtfulness, doing favors, and support of decisions made), and wellbeing, and lower post-test scores on negative dimensions of parent adult relationships (anger/hostility, insensitivity, demanding favors, and doubts on decisions made). Actor-partner interdependence models suggested that post-test outcome scores of parents and young adults were mutually interdependent and associated. With adequate emphasis on program compliance and some refinements for participant dyads with less formal education, music sessions enhance relationality and can be an effective family-based intervention for persons with diverse sexual identities.

Person-Centred, Culturally Appropriate Music Intervention to Improve Psychological Wellbeing of Residents with Advanced Dementia Living in Australian Rural Residential Aged Care Homes.

This quasi-experimental, nonrandomized intervention study reports the effect of person-centred, culturally appropriate music on psychological wellbeing of residents with advanced dementia in five rural residential aged care homes in Australia. Seventy-four residents attended in person-centred music sessions and culturally appropriate group sessions. Interest, response, initiation, involvement, enjoyment, and general reactions of the residents were assessed using the Music in Dementia Assessment Scale (MiDAS), and interviews and focus groups were conducted with aged care staff and musicians. The overall effect of person-centred sessions at two-time points were: during the intervention-351.2 (SD 93.5); and two-hours post intervention-315.1 (SD 98.5). The residents presented a moderate to high level of interest, response, initiation, involvement, and enjoyment during the session and at post-intervention. However, the MiDAS sub-categories' mean scores differed between the time-points: interest (t59 = 2.8, p = 0.001); response (t59 = 2.9, p = 0.005); initiation (t59 = 2.4, p = 0.019); and involvement (t59 = 2.8, p = 0.007), indicating a significant decline in the effect of person-centred music over time. Interestingly, during the period of time, most of the residents were observed with no exhibitions of agitation (87.5%), low in mood (87.5%), and anxiousness (70.3%), and with a presentation of relaxation (75.5%), attentiveness (56.5%), and smiling (56.9%). Themes from qualitative data collected regarding culturally appropriate group music sessions were behavioural change, meaningful interaction, being initiative, increased participation, and contentment. The findings suggest that the integration of music into care plans may reduce the residents' agitation and improve their emotional wellbeing in rural aged care homes.

How Music Moves Us: Music-induced Emotion Influences Motor Learning

Music is an important tool for the induction and regulation of emotion. Although learning a sequential motor behaviour is essential to normal motor function, to our knowledge, the role of music-induced emotion on motor learning has not been explored. Our experiment aimed to determine whether listening to different emotional music could influence motor sequence learning. We focused on two sub-components of motor sequence learning: the acquisition of the order of the elements in the sequence (the “what”), and the ability to carry out the sequence, combining the elements in a single, skilled action (the “how”). Twenty subjects performed a motor sequence-learning task with a digitizing tablet in three different experimental sessions. In each session they executed the task while listening to three different musical pieces, eliciting fearful, pleasant, and neutral mood. Eight targets were presented in a pre-set order and subjects were asked to learn the sequence while moving. Music-induced pleasure had an impact on movement kinematics with onset time and peak velocity decreasing and movement time increasing more with respect to neutral music session. Declarative learning, verbal recall of the sequence order, was improved under emotional manipulation, but only for fear-condition. Results suggest that music-induced emotion can influence both sub-components of motor learning in a different way. Music-induced pleasure may have improved motor components of sequence learning by means of increased striatal dopamine availability whereas music-induced fear may facilitate the recruitment of attentional circuits, thus acting on declarative knowledge of the sequence order.

Comparing the benefits of parent–infant flute and singing groups for communication and parenting: A feasibility study

There is growing evidence highlighting benefits of musical exposure and participation on several aspects of development and parenting. Aiming to establish a rigorous protocol allowing researchers to study different types of musical interactions and their benefits on the development of early communication, the present study explored parents’ experiences of musically engaging with their infants in different types of music groups. Twenty-five infants and their parents were randomly assigned to one of three groups: (1) singing, (2) flute playing, or (3) control group. Music sessions were held weekly for 14 weeks and were followed by the home use of the recorded routines specific of each group, for further 3 months. Semi-structured interviews were conducted with the experimental groups’ participants, and pre/post quantitative developmental measures were collected from all groups, to assess participants’ compliance. Qualitative analyses of the interviews revealed both shared themes, (communication enhancement, enjoyment, and regulation); and unique themes (creativity and freedom in the flute group; familiarity and responsiveness in the singing group). The feasibility study was successful in establishing a workable protocol to use in RCT longitudinal interventions aiming to examine how specific aspects of the musical experience might differentially support developmental outcomes, in parent–infant groups.

GenéLive! Generating Rhythm Actions in Love Live!

This article presents our generative model for rhythm action games together with applications in business operation. Rhythm action games are video games in which the player is challenged to issue commands at the right timings during a music session. The timings are rendered in the chart, which consists of visual symbols, called notes, flying through the screen. We introduce our deep generative model, GenéLive!, which outperforms the state-of-the-art model by taking into account musical structures through beats and temporal scales. Thanks to its favorable performance, GenéLive! was put into operation at KLab Inc., a Japan-based video game developer, and reduced the business cost of chart generation by as much as half. The application target included the phenomenal "Love Live!", which has more than 10 million users across Asia and beyond, and is one of the few rhythm action franchises that has led the online era of the genre. In this article, we evaluate the generative performance of GenéLive! using production datasets at KLab as well as open datasets for reproducibility, while the model continues to operate in their business. Our code and the model, tuned and trained using a supercomputer, are publicly available.

Parents and Teachers’ Perceptions of Online Music Sessions for Children with Autism During the Covid-19 Pandemic in Malaysia: An Exploratory Feasibility Study

Parents and Teachers’ Perceptions of Online Music Sessions for Children with Autism During the Covid-19 Pandemic in Malaysia: An Exploratory Feasibility Study

The Effect of Music as a Non-Pharmacological Intervention on the Physiological, Psychological, and Social Response of Patients in an Intensive Care Unit.

Music is an intriguing but relatively under-researched intervention with many potential benefits for mechanically ventilated patients. The review aimed to assess the impact of listening to music as a non-pharmacological intervention on the physiological, psychological, and social responses of patients in an intensive care unit. The literature review was conducted in the fourth quarter of 2022. The overview included papers found in Science Direct, EBSCO, PubMed, Ovid, Scopus, and original research papers published in English meeting the PICOS criteria. Articles published between 2010 and 2022 meeting the inclusion criteria were included for further analysis. Music significantly affects vital parameters: decreases the heart rate, blood pressure, and breathing; reduces pain intensity. The analyses confirmed that music affects anxiety levels, reduces sleep disturbances and delirium occurrence, and improves cognitive function. The effectiveness of the intervention is influenced by the choice of music. There is evidence of the beneficial effects of music on a patient's physiological, psychological, and social responses. Music therapy is highly effective in reducing anxiety and pain and stabilizes physiological parameters, i.e., the heart rate and respiratory rate, after music sessions in mechanically ventilated patients. Studies show that music reduces agitation in confused patients, improves mood, and facilitates communication.

Electroencephalographic interbrain synchronization in children with disabilities, their parents, and neurologic music therapists.

As with typically developing children, children with cerebral palsy and autism spectrum disorder develop important socio-emotional rapport with their parents and healthcare providers. However, the neural mechanisms underlying these relationships have been less studied. By simultaneously measuring the brain activity of multiple individuals, interbrain synchronization could serve as a neurophysiological marker of social-emotional responses. Music evokes emotional and physiological responses and enhances social cohesion. These characteristics of music have fostered its deployment as a therapeutic medium in clinical settings. Therefore, this study investigated two aspects of interbrain synchronization, namely, its phase and directionality, in child-parent (CP) and child-therapist (CT) dyads during music and storytelling sessions (as a comparison). A total of 17 participants (seven cerebral palsy or autism spectrum disorder children [aged 12-18 years], their parents, and three neurologic music therapists) completed this study, comprising seven CP and seven CT dyads. Each music therapist worked with two or three children. We found that session type, dyadic relationship, frequency band, and brain region were significantly related to the degree of interbrain synchronization and its directionality. Particularly, music sessions and CP dyads were associated with higher interbrain synchronization and stronger directionality. Delta (.5-4Hz) range showed the highest phase locking value in both CP and CT dyads in frontal brain regions. It appears that synchronization is directed predominantly from parent to child, that is, parents and music therapists' brain activity tended to influence a child's. Our findings encourage further research into neural synchrony in children with disabilities, especially in musical contexts, and its implications for social and emotional development.

Older Adults, Well-Being, and Affect: Music Sessions Vis-à-Vis Music-With-Meditation Sessions

ABSTRACT This article reports a study on the impact of music sessions compared with music-with-meditation sessions for older adults’ well-being and affect balance. Participants who attended music-with-meditation sessions over a period of 6 months, reported significant improvements in scores on measures of affect balance, psychological resources and strengths, and satisfaction with life. Gains were higher for female older adults, participants who had a college or postgraduate degree, retired or homemakers, currently married or widowed, and older adults who lived with spouse and family including adult children or with adult children alone. Program compliance indicated through regular attendance at the music-with-meditation sessions and completion of corresponding homework sessions were strongest predictors of improvements in older adults’ wellbeing and affect balance. An augmented and improvised music intervention, embellished with meditation sessions, is effective in bolstering psychological resources for older adults. Some program refinements would be needed for male older adults, participants with lower formal education or those who have professional degrees, in-service or self-employed, ever-single or divorced/separated older adults, and those living with other kith-kin, alone, or in institutions/assisted living facilities.

A CROSS SECTIONAL OBSERVATIONAL STUDY ON THE EFFECT OF MUSIC ON THE ANXIETY STATE OF PATIENTS ADMITTED FOR COVID 19 IN A TERTIARY CARE HOSPITAL IN NEW DELHI

Background: COVID 19 has led to dramatic changes in the lives of people leading to an increase in stress and anxiety. Music intervention is a non-medicated method for relieving anxiety. This current study aims to understand whether music can be effectively used to alleviate anxiety in admitted COVID-19 patients. Objective: To study the effect of music on anxiety in patients admitted for COVID-19 in a tertiary care hospital in New Delhi Method: 34 patients (17 females &amp;17 males) were randomly divided into two groups, a control (N=17) and a music group (N=17). Vitals of all the patients were noted. Patients of the music group were asked to listen to relaxing instrumental for 30 minutes, while patients of the control group were asked to relax for 30 minutes. Vitals of all the patients were noted again. Patients were asked to fill State Trait Anxiety Inventory (STAI) before and after intervention. Results: The post-intervention mean scores of STAI after the music session were lower in the music group than the control group [95.06 (SD 8.5)) versus 102.37 (SD 10.3)]. The differences in mean values of pre- to post-intervention changes between both groups after music session were statistically significant. Conclusions: Our findings suggest that listening to music lowers anxiety. As music is non- invasive and free of side-effects we recommend that music intervention service should be used to improve health care quality.

Music and Movement for Health: Protocol for a pragmatic cluster-randomised feasibility pilot trial of an arts-based programme for the health and wellbeing of older adults.

Background: Arts-based health programmes (ABHP) can enhance the physical and psychosocial health and wellbeing of older people. However, the feasibility and usefulness of such programmes in Ireland are currently unknown. The primary aim of this study is to examine the feasibility of the study design, its application to a music and movement for health programme and associated costs. The secondary aim is to obtain preliminary effect estimates of an ABHP on health and wellbeing in older adults. Methods: This study is a pragmatic cluster-randomised controlled feasibility trial. Community-dwelling adults, aged 65 years or older will be recruited in the mid-west region of Ireland via methods including social prescription, traditional and social media. The clusters, based on geographical region, will be block randomised to either the ABHP or control using 1:1 allocation ratio. The programme will comprise a 1.5-hour music and dance session each week for 12-weeks together with a 1-hour home-based music and movement programme for 12-weeks. A qualitative and quantitative process evaluation of the arts-based health programme will be performed. Outcomes: Primary outcomes for feasibility include recruitment rates (the number of participants recruited per cluster per month); retention rate (the number of participants who complete measures at baseline and at follow up post intervention, and minimum average attendance. Secondary outcomes will include physical function, balance, physical activity, loneliness, social isolation, cognition, mood, as well as quality of life and cost. Conclusions: If this pioneering study finds evidence to support feasibility and acceptability, a future larger-scale definitive trial will be conducted to examine the effectiveness of an arts-based health programme for older adults. This research aims to strengthen collaborative efforts to implement effective, sustainable and cost-effective programmes for older adults to support community connection, enhancing health and wellbeing, in turn reducing demands on the healthcare system. ISRCTN registration: ISRCTN35313497 (18/02/2022).

Live and Recorded Music Interventions to Reduce Postoperative Pain: Protocol for a Nonrandomized Controlled Trial.

Postoperative patients who were previously engaged in the live musical intervention Meaningful Music in Healthcare reported significantly reduced perception of pain than patients without the intervention. This encouraging finding indicates a potential for postsurgical musical interventions to have a place in standard care as therapeutic pain relief. However, live music is logistically complex in hospital settings, and previous studies have reported the more cost-effective recorded music to serve as a similar pain-reducing function in postsurgical patients. Moreover, little is known about the potential underlying physiological mechanisms that may be responsible for the reduced pain perceived by patients after the live music intervention. The primary objective is to see whether a live music intervention can significantly lower perceived postoperative pain compared to a recorded music intervention and do-nothing control. The secondary objective is to explore the neuroinflammatory underpinnings of postoperative pain and the potential role of a music intervention in mitigating neuroinflammation. This intervention study will compare subjective postsurgical pain ratings among 3 groups: live music intervention, recorded music intervention, and standard care control. The design will take the form of an on-off nonrandomized controlled trial. Adult patients undergoing elective surgery will be invited to participate. The intervention is a daily music session of up to 30 minutes for a maximum of 5 days. The live music intervention group is visited by professional musicians once a day for 15 minutes and will be asked to interact. The recorded music active control intervention group receives 15 minutes of preselected music over headphones. The do-nothing group receives typical postsurgical care that does not include music. At study completion, we will have an empirical indication of whether live music or recorded music has a significant impact on postoperative perceived pain. We hypothesize that the live music intervention will have more impact than recorded music but that both will reduce the perceived pain more than care-as-usual. We will moreover have the preliminary evidence of the physiological underpinnings responsible for reducing the perceived pain during a music intervention, from which hypotheses for future research may be derived. Live music can provide relief from pain experienced by patients recovering from surgery; however, it is not known to what degree live music improves the patients' pain experience than the logistically simpler alternative of recorded music. Upon completion, this study will be able to statistically compare live versus recorded music. This study will moreover be able to provide insight into the neurophysiological mechanisms involved in reduced pain perception as a result of postoperative music listening. The Netherlands Central Commission on Human Research NL76900.042.21; https://www.toetsingonline.nl/to/ccmo_search.nsf/fABRpop?readform&unids=F2CA4A88E6040A45C1258791001AEA44. PRR1-10.2196/40034.

Comparing Effects of Massage Therapy and Music on Chemotherapy-Induced Nausea and Vomiting in Cancer Children: A Randomized Control Trial

Background: Nausea and vomiting are common complications of chemotherapy. Objectives: The present study aimed to evaluate the efficacy of massage and music on chemotherapy-induced nausea and vomiting (CINV) in the pediatric oncology ward in 2017. Methods: The present randomized controlled trial used the convenience sampling method, and all samples were randomly assigned to two massage or music therapy groups. Accordingly, all subjects received one massage session and one music session, with one washout session between the two interventions. The severity of nausea and vomiting before, immediately after, and one hour after chemotherapy was assessed using the Visual Analogue Scale (VAS) and after 12 hours using the adapted Rhodes index of nausea and vomiting for pediatrics by child (ARINVC). The collected was analyzed with SPSS software version 18 using the repeated measures analysis of variance, Friedman test, chi-square, Fisher's exact, and independent t-test. Results: The results showed that nausea and vomiting scores were not significantly different between the two groups (P &gt; 0.05). However, the scores significantly increased in both methods immediately after the intervention, simultaneous with chemotherapy (P &lt; 0.05), and decreased below the baseline; however, they were not significantly different from the pre-intervention scores (P &gt; 0.05). In the second phase, one hour after the intervention, the scores of nausea and vomiting decreased below the baseline, which was significantly different from the pre-intervention scores (P &lt; 0.05). Conclusions: The massage or music therapy methods revealed no difference in reducing the severity of chemotherapy-induced nausea and vomiting in children. Nurses can use non-medicinal methods such as massage and music to reduce the complications of chemotherapy, especially nausea, and vomiting.