Osteoporosis has been defined as a skeletal disorder characterized by compromised bone strength, predisposing a person to increased risk of fracture.1 The three major osteoporotic fractures are those of the forearm, vertebra and hip, but fractures of the humerus, pelvis and ribs are also common. The incidence of these fracture rises steeply with age, such that most occur in people aged >65 years, where they are associated with excess mortality, substantial morbidity, and significant health and social services expenditure.2 This paper outlines the physiological roles of calcium and vitamin D, and assesses the current criteria for adequate calcium intake and optimal vitamin D status in adults. It highlights the prevalence of vitamin D insufficiency and low calcium intake in the UK, and reviews studies of vitamin D supplementation, with and without calcium, in the prevention of falls and fractures. Relevant clinical trials were identified using the search strategies described in recent meta-analyses.3,,4 Calcium is required for a number of functions in the body, including neuromuscular activity, membrane function, hormone secretion, enzyme activity, coagulation of the blood and skeletal mineralization.5 Over 99% of the body's calcium is stored in bone, where it provides mechanical strength to the skeleton, and serves as a mineral reservoir that can be drawn upon to maintain a normal plasma calcium. An adequate dietary calcium is therefore required to offset the obligatory losses of calcium in the urine and digestive juices, and prevent unnecessary loss of calcium from the skeletal reservoir.5 The recommended dietary calcium intake varies widely from country to country.6 In the US an intake of between 1000 and 1500 mg/day is recommended for adults, depending on age, gender and menstrual status.7 In contrast, the UK Committee on the Medical Aspects of Food and Nutrition Policy (COMA) … Address correspondence to Professor R.M. Francis, Musculoskeletal Unit, Freeman Hospital, Newcastle upon Tyne NE7 7DN. email: rmfrancis{at}compuserve.com