Duchenne muscular dystrophy is a genetic disease that causes a reduction in the expression of dystrophin, thus, with the reduction of the levels of this protein, a progression of muscle atrophy, reduction of strength and physical impairments is identified, which culminates in death from inability to contract the respiratory muscles. Creatine is a dietary supplement that helps maintain strength and recent findings indicate a potential anti-inflammatory effect of this amine. The present study aimed to compare the progress of muscular dystrophy in terms of inflammation, presence of intramuscular glycogen and tissue fibrosis in the gastrocnemius and pectoralis major muscles of MDX mice. We selected 20 MDX mice that were supplemented or not with creatine at a dosage of 0.3 grams per kilogram of body weight, for 16 weeks. After that, the gastrocnemius and pectoralis major were extracted for morphological and morphometric analysis. The inflammatory progress derived from Duchenne muscular dystrophy affects animals, even when supplemented, however, in a less forceful and disabling way, enabling them to have less functional damage. Nevertheless, the supplemented animals have a greater stock of intramuscular glycogen in the evaluated gastrocnemius tissue, a factor that corroborates with the survival and better quality of movement in these animals, given the availability of energy for the contraction of this musculature. Furthermore, a lower frequency and extent of tissue fibrosis is observed in supplemented animals, aspects that enable longer survival and qualify creatine, even in an experimental condition, as an auxiliary supplement in the treatment of a severe dystrophic condition, acting mainly in the maintenance of strength and reduction of local tissue fibrosis.