Murraya Koenigii Leaves Research Articles

Green Protocol for the Synthesis of Luminescent Carbon Nanodots Derived from Murraya Koenigii Leaves and Urea: Enhancing Photoluminescence for Advanced Bioimaging.

We have synthesized Murraya Koenigii leaves powder-derived carbon nanodots (CNDs) by hydrothermal method. A tribute to our commitment to environmental sustainability is the unique composition of our CNDs, which are made entirely of natural carbon sources and a green solvent, water. Our further efforts to improve performance led us to start making nitrogen-doped CNDs. By using urea as a non-toxic source of nitrogen, we observed a substantial increase in fluorescence intensity, extending the usefulness and potential of these nanomaterials. We investigated the optical properties using UV-Vis and fluorescence spectroscopy. The other parameters, like structural and size-shape morphology, were analyzed using FTIR, XRD, and HR-TEM, respectively. The fluorescence spectroscopy demonstrated their capability to exhibit wavelength-dependent photoluminescence (PL), highlighting the potential of these CNDs for cell bioimaging applications. The fluorescence properties affirm their suitability for biomedical applications, as they do not involve any inherent risk to cells.

Synthesis and Characterization of Silver Nanoparticles by Murraya Koenigii Leaves

Nanoparticles have a size of 1nm-100nm in any one of the three dimensions. Smaller nanoparticles have different physical, chemical and biological properties than atoms and molecules. Metals, non-oxide ceramic materials, metal oxides, silicates, and polymers, and organic and biomolecular components can be used to create material nanoparticles. Nanoparticles come in various shapes, like spheres, platelets, cylinders, and tubes. Green synthesized nanoparticles are not costly due to unemployment of toxic and hazardous compounds. Plants are widely spread, freely accessible, and safe to touch. They also supply a variety of metabolic compounds which are advantageous in reducing, capping and stabilizing process throughout in synthesis process. The reduction mechanism is based on the phytochemicals present in plant extract. In present work we synthesize silver nanoparticles by using Murraya Koenigii leaves through ecofriendly method. For synthesis of Silver nanoparticles, Silver nitrate (AgNO3) used as metal precursor salt and green extract of Murraya Koenigii used as reducing and capping agent for formation of nanoparticles. The nanoparticles then formed characterized by X-ray diffraction, Scanning electron microscope, Energy dispersive spectroscopy, Dynamic light scattering, Fourier transform infrared spectroscopy and optical properties by UV-Visible spectroscopy. XRD revealed the crystalline structure of silver nanoparticles, FESEM and Dynamic light scattering reveled the particle size of 60 nm, FTIR revealed the presence of different functional groups which are attached with sample and Optical properties of sample revealed by UV-Visible spectroscopy that also satisies different experimental results.

Moth Bean, Gelatin, and Murraya Koenigii Leaves Extract-Based Film and Coating: Effect of Coating on Shelf and Quality of Solanum Melongena

Moth bean starch (MS), gelatin (GA), and Murraya koenigii leaves extract (ME) are blended at different compositions to prepare film and coating according to casting and dipping approaches. Different MS, GA, and ME compositions were used to synthesize films and coating. The film compositions (MS : GA: ME: 60 : 20 : 20 and MS : GA: ME:20 : 60 : 20) were represented in terms of F3 and F4, respectively. The results showed that F3 exhibited better physicochemical properties than other films. In addition, SEM images showed that all components of the films were uniformly mixed and formed smooth surface morphology without cracks and bubbles. FTIR results indicate that ME in the films induces interactions between the film components, causing an improvement in compactness. Moreover, an optimized film-forming solution was tested as a coating. Parameters such as skin tightness, weight loss, pH, titratable acidity, and sensory analysis were considered to check the quality of coated Solanum melongena during storage. The results show that the formulation effectively maintains the quality parameters during storage. Furthermore, it also notices that coating extends the shelf life of Solanum melongena by one week.

Mnemonic and Histopathological Assessment of the Neuroprotective Effects of Murraya Koenigii Leaves Extract in Rats with Partial Global Cerebral Ischaemia

Introduction: Preclinical studies have reported that Murraya koenigii leaves (MKL) could enhance memory. MKL is also known for its antioxidant activity. The current study was to assess the possible neuroprotective potential of MKL methanolic extract in a two vessel occlusion (2VO) rat model of partial global cerebral ischaemia. Methods: Rats were divided into memory and learning groups. Each group was subdivided into sham control, untreated 2VO and MKL-treated 2VO subgroups. The Morris water maze test was implemented to assess the rats’ cognitive function postoperatively. Brain samples were histopathologically examined for viable neurons within the CA1 hippocampal region. Results: Water maze test findings showed that MKL positively improved memory and learning impairments. However, this improvement in memory test for the treated group was still significantly inferior to that of the healthy control group. Additionally, MKL treated group exhibited insignificant difference in the number of viable hippocampal CA1 pyramidal neurons from that of the untreated 2VO group, whereas both MKL treated and untreated 2VO groups showed significantly less viable neurons when compared with the control group. Conclusion: MKL extract modestly improved memory without providing substantial neuroprotective action to the hippocampal neurons in rats with chronic partial global cerebral ischaemia.

Evaluation of Antiasthmatic Activity of Murraya Koenigii L. Leaves

The present investigation was designed to evaluate the anti-asthmatic activity of ethanolic extract of Murraya Koenigii Leaves in experimental animals. Murraya Koenigii Leaves was evaluated for anti-histaminic activity using isolated Guinea pig tracheal chain preparation, histamine induced Bronchoconstriction in Guinea pig and milk induced leucocytosis in mice. Ethanolic extract of Murraya Koenigii Leaves oral dose 400mg/kg body weight significantly inhibited dose dependent contraction of Guinea pig tracheal chain produced by histamine and also showed significant protection by prolonging PreConvulsion Dyspnoea time (PCT) in guinea pigs. Murraya Koenigii Leaves was evaluated by milk induced leucocytosis in mice showed significant decreased of total leukocyte count. Thus, Murraya Koenigii Leaves showed anti-allergic activity against histamine hence possesses potential role in the treatment of asthma.

Eco-friendly Green Synthesis and Characterization of Silver Nanoparticles Derived from Murraya koenigii Leaves Extract

Eco-friendly Green Synthesis and Characterization of Silver Nanoparticles Derived from Murraya koenigii Leaves Extract

Beneficial Effects of Murraya Koenigii Leaves Chloroform Extract (MKCE) on Erythrocyte, Thrombocyte and Leukocyte Indices in Lead-intoxicated Mice

Introduction Acute or chronic exposure to lead induces dysfunction in physiological, biochemical and behavioural parameters in the body. It is one of current interesting studies of different sequestering agents to chelate heavy metals for minimizing toxicities and safe for use. Synthetic chelatin

Role of Hydroalcoholic and Aqueous leaf extracts of Murraya koenigii in Gastroprotection

Murraya koenigii leaves are regularly used in our diet and hence, our gastrointestinal tract is regularly exposed to this extract. Therefore the present study was focused on the evaluation of the Gastroprotective action of Murraya koenigii leaf extracts on Pancreas and Duodenum. Male albino mice (35-40 gm) were treated with Murraya koenigii leaf extracts (Hydroalcoholic and Aqueous), against Carbon tetrachloride (CCl 4 ) induced toxic model for seven days, using two different dose concentrations. The mice were divided into six groups, including Group I Untreated Controls and Group I A Vehicle controls. The negative control (Group II) was administered CCl 4 along with vehicle (olive oil) . Group III and IV were administered low dose (150 mg/kg body weight) of aqueous and hydroalcoholic extracts after inducing toxicity with CCl 4. Similarly , Group V and VI were administered with high dose (250mg/kg body weight) of the extracts. Biochemical markers included ATPase, ALKpase, ACPase, SDH, Protein and Cholesterol in both target tissues; duodenal Triglycerides and Pancreatic amylase were also estimated. It was observed that Murraya koenigii leaf extracts had a mitigative effect and were able to bring the elevated levels of ATPase, SDH, ALKPase, ACPase and Amylase to near normal values. The hydroalcoholic extract proved to be more effective than the aqueous extract. Hence, Murraya koenigii leaf extracts have potent ameliorative action on the CCl4 induced toxicity in the duodenum and pancreas, manifesting potent gastroprotective activity. The present study has significant impact since the plant is used extensively in both cuisine and medication.

Antioxidant and Antifungal Potential of Murraya Koenigii Leaves Extracts (Crude) and Essential Oil

The present study was aimed for the evaluation of antioxidant activity and antifungal activity of essential oil and crude extracts (methanol and ethanol) of Murraya koenigii leaves. The antioxidant activity of these extracts was determined by DPPH (1, 1- Diphenyl- 2- picrylhydrazyl) assay. It was found that free radical scavenging activity of Murraya koenigii essential oil and crude extracts was significantly higher in methanol extract among all the extracts studied. The extracts showed lower antioxidant activity compared to ascorbic acid used as reference. Similarly, the antifungal activity of these extracts was determined by poisoned food technique. On comparing the antifungal activities of three extracts on Fusarium oxysporum and Rhizoctonia solani, the activity of methanol extract was higher against Rhizoctonia solani than Fusarium oxysporum in comparison to rest of the extract, while essential oil showed moderate activity. The extracts showed lower antifungal activity compared to acetic acid used as reference. Therefore Murraya koenigii can be used as medicinal agents beneficial for enhancing the antioxidant and antifungal activity.

An aqueous extract of Murraya koenigii leaves induces paraoxonase 1 activity in streptozotocin induced diabetic mice

Murraya koenigii (Mk) leaves possess a hypoglycemic effect. Activity of paraoxonase 1 (PON1), a HDL-associated antioxidant enzyme, was found to be decreased during hyperglycemia. The present study explored the effect of Murraya koenigii leaves (MkL) on paraoxonase 1 activity in order to control the oxidative stress in diabetes. Hyperglycemia was induced in mice by a single dose of streptozotocin (200 mg kg(-1) body weight). Diabetic mice were treated with the aqueous extract of MkL orally once daily for 15 days. Doses of 75 and 150 mg kg(-1) body weight of the aqueous MkL extract decreased the blood sugar level significantly in a dose dependant manner. MkL administration significantly reduced oxidative stress by decreasing the MDA level and by increasing GSH level, SOD as well as catalase activity. However, PON1 activity was found to be increased after administration of aqueous MkL extract. MkL treatment also possesses a hypolipidemic effect as inferred from the decrease in total cholesterol, triglyceride level and increase in HDL-C concentration. Here we conclude that after MkL treatment, not only the antioxidant parameters like SOD, CAT, GSH and MDA, but also PON1 may be involved in decreasing the oxidative stress associated with diabetes.

Anti-inflammatory, analgesic and anti-ulcerogenic effect of total alkaloidal extract from Murraya koenigii leaves in animal models

The fresh leaves of Murraya koenigii are often added to various dishes in Asian countries due to the delicious taste and flavour that they impart. In the present study, the effect of the total alkaloidal extract from Murraya koenigii leaves (MKA) with respect to anti-inflammatory, analgesic and anti-ulcerogenic effects were evaluated using different experimental animal models. Oral supplementation of MKA at 10, 20 and 40 mg kg(-1) body weight successfully and dose-dependently reduced the formation of oedema induced by carrageenan, histamine and serotonin as well as formaldehyde-induced arthritis. In addition, the extract (10, 20 and 40 mg kg(-1), p.o.) attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by a subplantar injection of formalin in mice. MKA at higher doses (20 and 40 mg kg(-1), p.o) reduced the early phase response induced by formalin as well as reaction time on hot plate models. Interestingly, there was no ulcer score with the ulcerogenic effect of MKA. Moreover, all the doses of MKA (10, 20 and 40 mg kg(-1), p.o) showed promising anti-ulcerogenic activity with protection against acute gastric ulcers induced by ethanol plus hydrochloric acid and aspirin models in a dose dependent manner.

Protective effect of Murraya koenigii (L) leaves extract in streptozotocin induced diabetics rats involving possible antioxidant mechanism

Diabetes causes increased oxidative stress, which is thought to play an important role in the pathogenesis of various diabetic complications. The antioxidant actions are keys to preventing or reversing diabetes and its complications. Thus the aim of the present study was to evaluate the antioxidant potential of ethanolic Murraya koenigii leaves (MKL) extract on Thiobarbituric Acid Reactive Substances (TBARS) as index of lipid peroxidation and on the glycemic control in streptozotocin induced diabetic rats. Effect of oral administration of MKL (300 and 500 mg/kg) on the level of blood glucose, glycosylated haemoglobin, on TBARS and glycogen levels were estimated in streptozotocin induced diabetic rats. Glibenclamide was used as a standard drug. The elevated level of blood glucose, glycosylated haemoglobin, TBARS observed in diabetic rats were significantly altered compared to control but it not come to normal level after treatment with MKL for 15 days in diabetic rats. From the results it suggest that the ethanolic extract of M. koenigii possessed potent antioxidant properties which may be due to the presence of biological active ingredient such as carbazole alkaloids, glycoside, triterpenoids and phenolic compounds. Thus the antidiabetic activity of M. koenigii leaves was probably due to the presence of its antioxidant property. Key words: Diabetes mellitus, Murraya koenigii, antioxidant.

Nootropic Potential of Murraya koenigii leaves in Rats

Murraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

Antiamnesic potential of Murraya koenigii leaves

Murraya koenigii leaves commonly known as curry patta are added routinely to Indian gravy and vegetarian dishes as a favorite condiment. The effects of Murraya koenigii leaves (MKL) on cognitive functions, total serum cholesterol level and brain cholinesterase activity in young and aged mice fed orally with a diet containing 2%, 4% and 8% w/w of MKL for 30 days consecutively, were investigated. The memory scores were measured using various exteroceptive and interoceptive behavioral models. The MKL diets produced a significant dose-dependent improvement in the memory scores of young and aged mice and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Also, brain cholinesterase activity and total cholesterol levels were reduced by the MKL diets. The underlying mechanism of action for the observed nootropic effect may be attributed to pro-cholinergic activity and a cholesterol lowering property. Therefore, it would be worthwhile to investigate specifically the therapeutic potential of MKL in the management of Alzheimer patients.