Abstract
Introduction Acute or chronic exposure to lead induces dysfunction in physiological, biochemical and behavioural parameters in the body. It is one of current interesting studies of different sequestering agents to chelate heavy metals for minimizing toxicities and safe for use. Synthetic chelatin
Highlights
Acute or chronic exposure to lead induces dysfunction in physiological, biochemical and behavioural parameters in the body
The present study describes the in-vivo protective effects of Murraya koenigii Chloroform Extract (MKCE) against lead induced haemotoxicity in male albino Swiss mice
Acute lead exposure led to significant decrease in Red Blood Cells (RBC) (6.22 ± 0.15), HGB (9.35 ± 0.21), Packed Cell Volume (PCV) (28.48 ± 0.56), Red Cell Distribution Width-Standard Deviation (RDW-SD) (27.85 ± 0.40) and Red Cell Distribution Width-Correlation Variance (RDW-CV) (15.43 ± 0.45) in lead-intoxicated group as compared with respect to control group (P < 0.05)
Summary
Acute or chronic exposure to lead induces dysfunction in physiological, biochemical and behavioural parameters in the body. It is one of current interesting studies of different sequestering agents to chelate heavy metals for minimizing toxicities and safe for use. Occurring plant extracts have been proved since many years for their scavenging properties and restoring capabilities against oxidative stress. These have capacity for suppressing absorption of heavy metals into the body. Recent studies have been reported for the use of plant extracts like Withania somnifera 2 and Tinospora cordiflora 3 act as natural chelating agents to scavenge heavy metals in lieu of synthetic chelants and antioxidants
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