By means of a multicenter study a new contrast medium (SHU SOS A, Schering, Berlin, Germany) for colour cluplex sonography (CDS) was tested in 29 patients with cerebrovascular disease who showed in the native investigation (computed sonography system Acuson 128 XMP, Acuson, Calif., USA) insufficient signal intensity (SI) caused by dorso-medial origin of the internal carotid artery (ICA), mural calcifications, and for optimal evaluation of stenosis-grading, plaque morphology and demonstration of a residual lumen of the ICA. In all cases sufficient-to-optimal rise in CDS SI occurred, and no serious events during or after contrast-medium application were observed. The test agent is considered to be a convenient drug for raising CDS Sl in patients with low native colour signals. A systematical analysis of the multicenter study follow this report.
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