Due to the lack of normalized management, industrial waste is often co-disposed at open solid waste dumping sites, which could aggravate the groundwater pollution. In this study, 5 practical open solid waste dumping sites dealing with municipal solid wastes (MSW) (2 of 5) and industrial wastes mixed with MSW (3 of 5) were chosen to investigate the effect of waste co-disposal on the groundwater contamination. The industrial waste was mainly from rubber production, leather production, machinery industry, pharmaceutical industry and plastic production. 3 to 6 groundwater wells were excavated from each dumping site and 148 indices were analyzed, including regular chemicals, heavy metals, biological pollutants, volatile organic compounds (VOCs), semi-volatile organic compounds (SVOCs) and pesticide residues. Nemerow index analysis showed that 5 indices were severely polluted in the groundwater from every industrial waste co-disposal landfill, while only 0 and 1 severely polluted index was found for the two MSW landfill, respectively. The principal component analysis (PCA) analysis indicated that 2 biological pollutant (plate-counting bacteria (TPB) and total coliforms (TCs)), 4 chemical pollutants (permanganate index, ammonia, S2− and petroleum) were closely connected with the disposal of industrial waste. Besides, co-disposal of industrial waste also brought in series of PAHs and dichloromethane, with di(2-ethylhexyl)phthalate exceeding the standard limit (10.5 mg L−1). Attention should be paid to TPB and TCs, whose maximal concentrations exceeded the standard limit by extraordinary 3200 and 1600 times, respectively. The distribution pattern of the pollutants showed that the biological pollutants at the downstream area, and chemical pollutants at the leakage points exhibited the highest concentration, which indicated the downstream area and seepage points should be specially concerned for the industry waste co-disposed dumping sites.