Municipal solid waste (MSW) landfill slope failures can have significant consequences for the economy, environment, and human health. One potential cause of slope failure is insufficient reliability, resulting from inadequate design. The usual practice in the design of MSW landfills involves utilizing established geotechnical codes, such as Eurocode 7 (EC7), to perform slope stability assessments. Considering the substantial heterogeneity of MSW relative to soil, questions arise regarding the justification of such an approach in the design of MSW landfills. This study examines the suitability of applying EC7 in MSW landfill design, analyzing the stability and reliability of landfill slopes across various heights, front slope angles, design approaches, and consequence classes. This study finds that, in most cases considered, EC7 does not ensure an adequate level of reliability for MSW landfill slopes. Therefore, it is suggested that EC7 should be complemented with specific guidelines for incorporating MSW in geotechnical analyses to achieve the desired structural reliability. Adopting this strategy will not only enhance the reliability of landfill design but also promote the development of solutions that are economically and environmentally sustainable.