Climate change communication remains a vital issue globally in view of the increasing concerns on the adverse impacts of climate change. Using a total of 327 Ghanaians, this research investigated public perception on the level of effectiveness of climate change communication channels in the country. Simple random and convenience sampling methods were employed to select respondents who filled a set of questionnaires. In analyzing the data, cross tabulation, means, standard deviations, Mann-Whitney U test and Kruskal Wallis test were employed. Though many respondents believed climate change is already harming local communities, they were dissatisfied with the existing institutional, legal and regulatory frameworks for addressing climate change impacts. Also, the respondents believed that local authorities, the media and political officeholders were not actively addressing climate change impacts. Radio, television, and social media platforms were perceived as generally effective climate change communication channels in Ghana. However, respondents were lowly satisfied with the overall level of effectiveness of climate change communication channels in the country. Significant differences existed in the views of respondents on the effectiveness of climate change communication channels used in Ghana based on gender (Z score=-2.022, P<0.5). Similarly, there were significant differences in the views of respondents on the effectiveness of climate change communication channels and their level of education (X2 =23.763, P<0.05). The Ministry of Environment, Science and Innovation should team up with the Ministry of Local Government and Rural Development, and the Ministry of Information to develop a more comprehensive program aimed at promoting behavior and social change towards climate change adaptation and mitigation. The Metropolitan, Municipal and District Assemblies should liaise with community radios to come up with measures to promote the use of climate change communication channels based on the unique demographic characteristics and socio-cultural contexts of target audience.