Abstract A data driven structural change detection method is described and evaluated where the data are acceleration and force measurements from a mechanical structure in the form of a vehicle. By grouping the measured signals as inputs and outputs an hypothesized MIMO linear dynamic relation between the inputs and outputs is assumed. It is assumed that baseline data are available to build statistical models for the estimated frequency function of the baseline system at selected frequencies. When new data is available, the monitoring algorithm re-estimates the non-parametric frequency function and uses a test statistic based on the statistical distance to detect possible change. To generate the frequency function estimates a non-parametric MIMO frequency function estimator based on the local rational model (LRM) method is developed. A statistical analysis of the proposed test statistic shows that it has an F-distribution for data from the baseline case. The method is evaluated on simulated data from a high fidelity full scale vehicle simulation generating both baseline data and data from a structurally changed vehicle. In the evaluation, the frequency response functions were estimated by the non-parametric LRM method, the parametric ARX estimate and the non-parametric ETFE. The results show that all three methods can detect the structural change while the LRM method is more robust with respect to the selection of the hyperparameters.