Multivariate Canonical Correlation Research Articles

Emphasizing symbolic capital: its superior influence on the association between family socioeconomic status and adolescent subjective well-being uncovered by a large-scale multivariate network analysis.

Family socioeconomic status (FSES) serves as a significant determinant for subjective well-being. However, extant research has provided conflicting evidence on the correlation between FSES and adolescent students' subjective well-being (SSWB). Data were collected from 12,058 adolescent students (16 years of age) by the Programme for International Student Assessment (PISA) 2018. Multivariate canonical correlation and Mantel test were utilized to investigate the specific connection between FSES and SSWB. Furthermore, a Gaussian EBICglasso graph-theoretical model was used to capture the topological properties of the FSES-SSWB network and reveal the interplay among multifarious components of FSES and SSWB. FSES was positively correlated with SSWB. In the FSES-SSWB network, parental educational attainment and occupation status demonstrated the highest centrality values, thereby contributing significantly to the relationship between FSES and SSWB. However, family wealth, along with educational and cultural resources, displayed lower centrality values, signifying their weaker roles in this relationship. Our findings suggest that symbolic capital, rather than family affluence, exerts a dominant influence on adolescent SSWB. In other words, SSWB may not be detrimentally influenced by a deficiency in monetary resources. However, it is more susceptible to being unfavorably impacted by inferior parental educational attainment and occupational standing.

Cerebellum and social abilities: A structural and functional connectivity study in a transdiagnostic sample.

The cerebellum has been involved in social abilities and autism. Given that the cerebellum is connected to the cortex via the cerebello-thalamo-cortical loop, the connectivity between the cerebellum and cortical regions involved in social interactions, that is, the right temporo-parietal junction (rTPJ) has been studied in individuals with autism, who suffer from prototypical deficits in social abilities. However, existing studies with small samples of categorical, case-control comparisons have yielded inconsistent results due to the inherent heterogeneity of autism, suggesting that investigating how clinical dimensions are related to cerebellar-rTPJ functional connectivity might be more relevant. Therefore, our objective was to study the functional connectivity between the cerebellum and rTPJ, focusing on its association with social abilities from a dimensional perspective in a transdiagnostic sample. We analyzed structural magnetic resonance imaging (MRI) and functional MRI (fMRI) scans obtained during naturalistic films watching from a large transdiagnostic dataset, the Healthy Brain Network (HBN), and examined the association between cerebellum-rTPJ functional connectivity and social abilities measured with the social responsiveness scale (SRS). We conducted univariate seed-to-voxel analysis, multivariate canonical correlation analysis (CCA), and predictive support vector regression (SVR). We included 1404 subjects in the structural analysis (age: 10.516 ± 3.034, range: 5.822-21.820, 506 females) and 414 subjects in the functional analysis (age: 11.260 ± 3.318 years, range: 6.020-21.820, 161 females). Our CCA model revealed a significant association between cerebellum-rTPJ functional connectivity, full-scale IQ (FSIQ) and SRS scores. However, this effect was primarily driven by FSIQ as suggested by SVR and univariate seed-to-voxel analysis. We also demonstrated the specificity of the rTPJ and the influence of structural anatomy in this association. Our results suggest that there is a complex relationship between cerebellum-rTPJ connectivity, social performance and IQ. This relationship is specific to the cerebellum-rTPJ connectivity, and is largely related to structural anatomy in these two regions. PRACTITIONER POINTS: We analyzed cerebellum-right temporoparietal junction (rTPJ) connectivity in a pediatric transdiagnostic sample. We found a complex relationship between cerebellum and rTPJ connectivity, social performance and IQ. Cerebellum and rTPJ functional connectivity is related to structural anatomy in these two regions.

Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease

Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN), two complementary kidney function markers. However, it is unknown whether additional SNPs for kidney function can be identified by multivariate statistical analysis. To address this, we applied canonical correlation analysis (CCA), a multivariate method, to two individual-level CKD genotype datasets, and metaCCA to two published GWAS summary statistics datasets. We identified SNPs previously associated with kidney function by published univariate GWASs with high replication rates, validating the metaCCA method. We then extended discovery and identified previously unreported lead SNPs for both kidney function markers, jointly. These showed expression quantitative trait loci (eQTL) colocalisation with genes having significant differential expression between CKD and healthy individuals. Several of these identified lead missense SNPs were predicted to have a functional impact, including in SLC14A2. We also identified previously unreported lead SNPs that showed significant correlation with both kidney function markers, jointly, in the European ancestry CKDGen, National Unified Renal Translational Research Enterprise (NURTuRE)-CKD and Salford Kidney Study (SKS) datasets. Of these, rs3094060 colocalised with FLOT1 gene expression and was significantly more common in CKD cases in both NURTURE-CKD and SKS, than in the general population. Overall, by using multivariate analysis by CCA, we identified additional SNPs and genes for both kidney function and CKD, that can be prioritised for further CKD analyses.

Maternal fatty acid status during pregnancy versus offspring inflammatory markers: a canonical correlation analysis of the MEFAB cohort.

The development of inflammatory lung disorders in children may be related to maternal fatty acid intake during pregnancy. We therefore examined maternal fatty acid (FA) status during pregnancy and its associations with inflammatory markers and lung conditions in the child by analyzing data from the MEFAB cohort using multivariate canonical correlation analysis (CCA). In the MEFAB cohort, 39 different phospholipid FAs were measured in maternal plasma at 16, 22 and 32 weeks of pregnancy, and at day of birth. Child inflammatory markers and self-reported doctor diagnosis of inflammatory lung disorders were assessed at 7 years of age. Using CCA, we found that maternal FA levels during pregnancy were significantly associated with child inflammatory markers at 7 years of age and that Mead acid (20:3n-9) was the most important FA for this correlation. To further verify the importance of Mead acid, we examined the relation between maternal Mead acid levels at the day of birth with the development of inflammatory lung disorders in children at age 7. After stratification for the child's sex, maternal Mead acid levels at day of birth were significantly related with self-reported doctor diagnosis of asthma and lung infections in boys, and bronchitis and total number of lung disorders in girls. Future studies should investigate whether the importance of Mead acid in the relation between maternal FA status and inflammation and lung disorders in the child is due to its role as biomarker for essential fatty acid deficiency or due to its own biological function as pro-inflammatory mediator.

Pengaruh Aktivitas Belajar Siswa Menggunakan Model Problem Based Learning Terhadap Kemampuan 4c (Collaboration, Communication, Critical Thinking, Creative Thinking) Siswa Pada Materi Sistem Pernapasan Di SMA

The background of this research is Biology material about respiratory system' disease and disorders has not be linked to problems relevant on Students' life, Students' 4C capabilities are a global demand and students learning Activities have not fully paid attention to schools. Therefore, researcher tried to connect Students' Learning activities with Students' 4C capabilities in learning. The purpose of this study is to determine the effect of Students' learning activities using Problem Based Learning Model on 4C (Collaboration , Communication, Critical Thinking Creative Thinking) the capability of Students on Respiratory System Material. The research method used an experimental design. The population in this study are all students of class XI IPA at SMAN 1 Sukagumiwang in 2020/2020, the sampling technique is purposive as many as 20 students. Data collection techniques using tests, observation, quistionaires and documentation. Data analysis techniques used statistical and Multivariate Canonical Correlation. The results of this study are (1) Students learning activities using the PBL mod which has an effect on Students' 4C capabilities with an eigenvalue of 46.5 and the deoendent variabkr redudancy index explained by the independent Canonical variate of 97.8% and the independent variabkr redundancy index explained by the variable itsel. The dependent Canon is 68.5%, the eigenvakues indicate that the high level of learning activity Will affect the Students' 4C capabilities.

Tangent functional canonical correlation analysis for densities and shapes, with applications to multimodal imaging data

It is quite common for functional data arising from imaging data to assume values in infinite-dimensional manifolds. Uncovering associations between two or more such nonlinear functional data extracted from the same object across medical imaging modalities can assist development of personalized treatment strategies. We propose a method for canonical correlation analysis between paired probability densities or shapes of closed planar curves, routinely used in biomedical studies, which combines a convenient linearization and dimension reduction of the data using tangent space coordinates. Leveraging the fact that the corresponding manifolds are submanifolds of unit Hilbert spheres, we describe how finite-dimensional representations of the functional data objects can be easily computed, which then facilitates use of standard multivariate canonical correlation analysis methods. We further construct and visualize canonical variate directions directly on the space of densities or shapes. Utility of the method is demonstrated through numerical simulations and performance on a magnetic resonance imaging dataset of glioblastoma multiforme brain tumors.

Multivariate shoulder and spine relationship using planar range of motion assessment

ContextGoniometry and posture are commonly used metrics in clinical assessment of the shoulder and spine. When both the shoulder and spine are assessed individually using these techniques, there are structural and functional musculoskeletal relationships between the two anatomical regions that may be overlooked. ObjectiveTo determine the relationships between and within the shoulder and spine as measured by active range of motion (ROM) and spine curvature. DesignCross-sectional. SettingClinical assessment in university setting. Participants163 asymptomatic, right hand dominant, young adults; InterventionNone. Main outcome measuresA multivariate canonical correlation was used to identify a shoulder-spine relationship using active ROM assessments. ResultsA shoulder-spine relationship was determined using planar assessments and multivariate analyses of these two areas. Measures contributing to this relationship included shoulder flexion, internal rotation, external rotation, and trunk flexion and lumbar lordosis. ConclusionsThe findings of this study suggest that assessment of shoulder ROM should be interpreted with respect to spine region and vice versa, regardless of presenting region of concern, owing to the multivariate shoulder-spine ROM relationship when considering multiple measures of ROM and posture.

INFLUENCE OF THE LAURACEAE FAMILY ON THE DYNAMICS OF A MIXED OMBROPHILOUS FOREST REMNANT

Lauraceae family has one of the highest values of importance in the Mixed Ombrophilous Forest (MOF). The commercial value of some of its species was a reason for intense forest exploitation in the southern region of Brazil. Considering the hypothesis that it provides an essential subsidy for the constitution of this forest type, the aim of this study was to identify and quantify the influence of Lauraceae family in the dynamics of a 15.2 ha MOF remnant. Census data were collected every three years, since 2007, in which all trees with a circumference at 1.3 m height equal to or greater than 30 cm were identified and measured. Dynamics were analyzed by periodic increment in diameter, recruitment, and mortality through the measurement periods, while cluster multivariate analysis and canonical correlation were applied for grouping species and assessing their importance on the forest remnant dynamics. Diameter distribution prognosis of Lauraceae and its species was obtained through a transition matrix. Eleven tree species of Lauraceae family were identified, which showed decreasing diameter distribution and value of importance equals to 9.51%. Using cluster analysis, five groups were obtained, while the canonical correlation of 0.551 was considered moderate and statistically significant by Wilks’ Lambda test. By the projection of diameter distribution, it was verified that the study community is stable and self-regenerative. Although it is considered moderate, the influence of family on the forest remnant tends to increase with the advance of ecological succession.

Do Changes in Fitness Status, Testosterone Concentration, and Anthropometric Characteristics Across a 16-Month Training Period Influence Technical Performance of Youth Soccer Players During Small-Sided Games?

Rodrigues Lopes, RA, Aoki, MS, Carling, C, Vaz Ronque, ER, and Moreira, A. Do changes in fitness status, testosterone concentration, and anthropometric characteristics across a 16-month training period influence technical performance of youth soccer players during small-sided-games? J Strength Cond Res 36(5): 1404-1409, 2022-This study examined the influence of changes in physical capacity, testosterone concentration, and anthropometric characteristics across a 16-month training period on technical performance of youth players during small-sided games (SSG). Thirty-five elite youth players (14.3 ± 0.2 years, 170 ± 6.2 cm, and 61 ± 6 kg) were assessed on 3 occasions (T1, T2, and T3) over the period. A multivariate canonical correlation (MCC) was used to assess the multiple associations between the criterion variable (SSG technical performance) and the predictor variable (physical capacity represented by the Yo-Yo Intermittent Recovery Test Level 1 [Yo-Yo IRT1], testosterone concentration, and anthropometric characteristics). Changes between T1 and T3 were retained for MCC analysis. Multivariate canonical correlation analysis revealed 2 significant functions (R2 = 0.42 and 0.36) indicating a significant relationship between predictor and criterion variables. Changes in Yo-Yo IRT1 performance were the main contributor to the predictor variable, whereas the frequency of tackles/interceptions contributed mostly to the criterion variable (SSG technical performance). These results showed that technical performance in SSG was influenced by changes in Yo-Yo IRT1 performance, suggesting the importance of monitoring in conjunction, intermittent exercise capacity, and technical performance in SSG in youth soccer players. In addition, the stability in technical performance during SSG observed over the experimental period suggests that practitioners could use SSG as a tool for systematic real-world monitoring of technical performance rather than isolated practice drills.

Modeling the relationship between organizational performance and green supply chain practices using canonical correlation analysis

The world is moving towards a environmental restricted scenario where excellence and growth in business is contingent upon good governance and excellent green sustainability related policies, strategies and long-term values to stay ahead in competition. Green supply chain management (GSCM) practices play an essential role in shaping the way of offering environmental sustainable products and services to customers. Existing research insists that multiple pressure push organizations to navigate towards ‘eco design’, ‘green purchasing’ and ‘cooperation with customers’ leading to green supply chain management. But how these factors exactly impact the organisational performance based on green supply chain management is being explored in this research. Hypothesis developed is tested by using multivariate canonical correlation analysis to model the regression relationship of 54 manufacturing organizations. Green purchasing and eco-design are the main contributors of GSCM’s organisational performance. Cooperation with customer as major roadblock for organisational’s performance and requires management, to ponder over for improved results. The findings coincide with published research articles that were conducted in developing countries, such as Brazil and Jordan, to ensure environmental sustainability with the integration of GSCM practices.

Dispositions of agency as explanatory mechanisms of employees’ satisfaction with retention practices

This study explored the explanatory power of psychological dispositions of agency (i.e. employability attributes and organisational commitment) in relation to employees’ satisfaction with organisational retention practices. Participants were a convenience sample of employees from a higher education academic institution in South Africa (N = 311; females = 61%, black = 46%; age range = 31 to 45 years). The employees completed a biographical questionnaire, the Employability Attributes Scale (EAS), the Organisational Commitment Questionnaire (OCQ), and the Retention Factor Scale (RFS). A multivariate canonical correlation analysis showed that affective and normative commitment significantly explained the variance in satisfaction with compensation, training and development, and career opportunities. Career self-management and sociability attributes significantly explained satisfaction with career opportunities. Employee retention strategies that took into account dispositions of agency and retention practices satisfaction appear to prime employees for higher levels of organisational commitment.

Discovering markers of healthy aging: a prospective study in a Danish male birth cohort

There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recruited from the 1953 Danish Male Birth Cohort (N=193). Applying an extreme group design, members were selected in 2 groups based on cognitive change between IQ at age ~20y (IQ-20) and age ~57y (IQ-57). Subjects showing the highest (n=95) and lowest (n=98) change were selected (at age ~57) for assessments on multiple IDPs and non-IDPs. We investigated the relationship between 453 IDPs and 70 non-IDPs through pairwise correlation and multivariate canonical correlation analysis (CCA) models. Significant pairwise associations included positive associations between IQ-20 and gray-matter volume of the temporal pole. CCA identified a richer pattern - a single “positive-negative” mode of population co-variation coupling individual cross-subject variations in IDPs to an extensive range of non-IDP measures (r = 0.75, Pcorrected < 0.01). Specifically, this mode linked higher cognitive performance, positive early-life social factors, and mental health to a larger brain volume of several brain structures, overall volume, and microstructural properties of some white matter tracts. Interestingly, both statistical models identified IQ-20 and gray-matter volume of the temporal pole as important contributors to the inter-individual variation observed. The converging patterns provide novel insight into the importance of early adulthood intelligence as a significant marker of late-midlife neural decline and motivates additional study.

Investigation of the Relationship Between Susceptibility Loci for Hip Osteoarthritis and Dual X-Ray Absorptiometry-Derived Hip Shape in a Population-Based Cohort of PerimenopausalWomen.

To examine relationships between known osteoarthritis (OA) susceptibility loci and hip shape in a population-based cohort of perimenopausal women in order to investigate whether hip shape contributes to OA development. Hip shape was measured, using statistical shape modeling, on dual x-ray absorptiometry scans of the hip from mothers in the Avon Longitudinal Study of Parents and Children (ALSPAC). The proximal femur and superior acetabulum were outlined, and independent hip shape modes were generated. In a subregional model, points were restricted to the acetabulum and superior femoral head. Associations between 11 OA-related single-nucleotide polymorphisms, identified by literature search, and shape modes were analyzed in a multivariate canonical correlation analysis. A total of 3,111 women (mean age 48 years) had genetic and hip shape data. The KLHDC5/PTHLH rs10492367 OA risk allele was associated with a wider upper femur in the whole shape model (P = 1 × 10-5 ). The DOT1L rs12982744 OA risk allele was associated with reduced superior joint space in the subregional shape model (P = 2 × 10-3 ). The COL11A1 rs4907986 OA risk allele was associated with lateral displacement of the femoral head relative to the acetabulum in the subregional shape model (P = 5 × 10-4 ). Regional association plots identified an additional COL11A1 locus in moderate linkage disequilibrium with rs4907986, which was more strongly associated with hip shape (rs10047217; P = 3 × 10-6 ). Colocalization analysis indicated sharing of genetic signals for hip shape and hip OA for the KLHDC5/PTHLH and COL11A1 loci. Hip OA susceptibility loci were associated with shape in this study, suggesting that these loci (and potentially yet-to-be-identified hip OA loci) could contribute to hip OA in later life via perturbing biologic pathways that mediate morphology development.

Six NSCL/P Loci Show Associations With Normal-Range Craniofacial Variation.

Objectives: Orofacial clefting is one of the most prevalent craniofacial malformations. Previous research has demonstrated that unaffected relatives of patients with non-syndromic cleft lip with/without cleft palate (NSCL/P) show distinctive facial features, which can be an expression of underlying NSCL/P susceptibility genes. These results support the hypothesis that genes involved in the occurrence of a cleft also play a role in normal craniofacial development. In this study, we investigated the influence of genetic variants associated with NSCL/P on normal-range variation in facial shape.Methods: A literature review of genome wide association studies (GWAS) investigating the genetic etiology of NSCL/P was performed, resulting in a list of 75 single nucleotide polymorphisms (SNPs) located in 38 genetic loci. Genotype data were available for 65 of these selected SNPs in three datasets with a combined sample size of 7,418 participants of European ancestry, whose 3D facial images were also available. The effect of each SNP was tested using a multivariate canonical correlation analysis (CCA) against 63 hierarchically-constructed facial segments in each of the three datasets and meta-analyzed. This allowed for the investigation of associations between SNPs known to be involved in NSCL/P and normal-range facial shape variations in a global-to-local perspective, without preselecting specific facial shape features or characteristics.Results: Six NSCL/P SNPs showed significant associations with variation in normal-range facial morphology. rs6740960 showed significant effects in the chin area (p = 3.71 × 10−28). This SNP lies in a non-coding area. Another SNP, rs227731 near the NOG gene, showed a significant effect in the philtrum area (p = 1.96 × 10−16). Three SNPs showed significant effects on the shape of the nose. rs742071 (p = 8.71 × 10−14), rs34246903 (p = 6.87 × 10−12), and rs10512248 (p = 8.4 × 10−9). Respectively, these SNPs are annotated to PAX7, MSX1, and PTCH1. Finally, rs7590268, an intron variant of THADA, showed an effect in the shape of the supraorbital ridge (p = 3.84 × 10−7).Conclusions: This study provides additional evidence NSCL/P-associated genetic variants influence normal-range craniofacial morphology, with significant effects observed for the chin, the nose, the supraorbital ridges and the philtrum area.

Abstract 5210: Liver prometastatic genes in patients with and without colorectal cancer

Abstract Metastasis-related hepatic genes were investigated in the tumor-unaffected hepatic tissue from patients with hepatic colorectal cancer (CRC) metastases. In addition, the contribution of CRC and patient's clinical parameters and comorbidities to hepatic expression of CRC prometastatic genes was also studied in new hepatic biopsies from metastasis-free CRC patients and from CRC-free patients used as controls. The expression level of 58% metastasis-associated hepatic genes significantly changed between patients with and without CRC. Principal component and Linear discriminant statistical analyses, and a hierarchical cluster analysis based on Pearson's correlation indices uncovered a subset of 37 CRC-dependent liver prometastatic genes able to segregate patients with and without CRC. Functionally, they belonged to immune regulation, inflammation, metabolic bioprotection, hepatokines and regeneration factors. More importantly, a multivariate canonical correlation analysis showed the additional contribution of patient's pathophysiology and comorbidities to hepatic gene expression and metastasis risk. The liver prometastatic gene expression pattern represented a patient-specific and heterogeneous hepatic reaction to CRC-specific factors, which developed prior to metastatic recurrence and varied according to location of such CRC in the left and right-sided colonic area and rectum. Citation Format: Fernando Vidal-Vanaclocha. Liver prometastatic genes in patients with and without colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5210.

An Analysis of Multiple Stressors on Resident Benthic Communities in a California Agricultural Stream

This 3-year study (2015-2017) was designed to characterize benthic communities (macroinvertebrates) and physical habitat in an agriculturally dominated waterbody in the Central Coast area of California (Santa Maria River). Benthic communities as represented by various metrics that represent richness, composition, tolerance/intolerance and trophic measures were used as response variables for the various stressors described below. Concurrent water quality evaluations, physical sediment parameters (grain size and total organic carbon [TOC]), pyrethroids, bulk metals—including simultaneously extracted metals (SEM) and acid volatile sulfides (AVS) ratios—and nutrients were measured. The relationship of various benthic metrics to physical habitat metrics, pyrethroids, metals, nutrients and sediment characteristics was evaluated for the 3-year data set. Total physical habitat scores in this watershed were considered to be poor. Samples collected for various sediment chemistry measurements were from depositional areas (fine grain areas primarily silt and clay) where hydrophobic chemicals such as pyrethroids could be found if sources exist. Dominant benthic taxa collected were generally considered to be tolerant to moderately tolerant of environmental stressors and rated as impaired based on a benthic index. Potentially toxic sediment concentrations of arsenic, cadmium and nickel were reported at various sites based on a comparison with existing threshold effect levels. Pyrethroid concentrations interpreted by using a highly protective toxics units approach with a laboratory sensitive taxon ( Hyalella) suggested potential toxicity at various sites. Nutrient concentrations could not be interpreted within the context of potential impairment because the State of California has not developed nutrient criteria. The results of the stepwise linear regression models comparing benthic metrics with all environmental variables showed that TOC was the most important variable shaping the benthic communities. In contrast, pyrethroids, metals and physical habitat were not shown to be significant factors shaping benthic communities. The summary multivariate canonical correlation analysis indicated that less stressed, more diverse benthic communities tended to be associated more with TOC-rich finer sediments and lower concentrations of phosphorous-based nutrients, and more stressed, less diverse benthic communities tended to be associated with less organically rich, somewhat less fine sediments and higher phosphorous concentrations.

Is the technical performance of young soccer players influenced by hormonal status, sexual maturity, anthropometric profile, and physical performance?

The aim of this study was to examine the influence of hormonal status, anthropometric profile, sexual maturity level, and physical performance on the technical abilities of 40 young male soccer players during small-sided games (SSGs). Anthropometric profiling, saliva sampling, sexual maturity assessment (Tanner scale), and physical performance tests (Yo-Yo and vertical jumps) were conducted two weeks prior to the SSGs. Salivary testosterone was determined by the enzyme-linked immunosorbent assay method. Technical performance was determined by the frequency of actions during SSGs. Principal component analyses identified four technical actions of importance: total number of passes, effectiveness, goal attempts, and total tackles. A multivariate canonical correlation analysis was then employed to verify the prediction of a multiple dependent variables set (composed of four technical actions) from an independent set of variables, composed of testosterone concentration, stage of pubic hair and genitalia development, vertical jumps and Yo-Yo performance. A moderate-to-large relationship between the technical performance set and the independent set was observed. The canonical correlation was 0.75 with a canonical R2 of 0.45. The highest structure coefficient in the technical performance set was observed for tackles (0.77), while testosterone presented the highest structure coefficient (0.75) for the variables of the independent set. The current data suggest that the selected independent set of variables might be useful in predicting SSG performance in young soccer players. Coaches should be aware that physical development plays a key role in technical performance to avoid decision-making mistakes during the selection of young players.

Statistical Analysis of Causality between Capital Structure and Firm Profitability: Evidence from Bosnia and Herzegovina

Abstract This research is designed to examine the relationship between the capital structure and profitability of non-financial firms in Bosnia and Herzegovina during the ten years period, from 2003-2012. The goal is to prove the existence of the relationship between the firm’s capital structure choice and its profitability. The analysis is extended by including the debt structure and differentiating between the types of debt such as the long-term and the short-term ones. Canonical correlation and multiple regression analysis are used. The results of the multivariate canonical correlation analysis provide support to a hypothesis that the capital structure and profitability have statistically significant relationships. Furthermore, the findings provide support that firms develop different patterns of profitability depending on the capital structure choice. We found that an increasing proportion of short-term debt and long-term debt in the overall liability of the firm reduces its profitability.

Effect of Toothpaste Application Prior to Dental Bleaching on Whitening Effectiveness and Enamel Properties.

The purpose of this study was to investigate the effects on the enamel properties and effectiveness of bleaching using 35% hydrogen peroxide (HP) when applying toothpastes with different active agents prior to dental bleaching. Seventy enamel blocks (4 × 4 × 2 mm) were submitted to in vitro treatment protocols in a tooth-brushing machine (n=10): with distilled water and exposure to placebo gel (negative control [NC]) or HP bleaching (positive control [PC]); and brushing with differing toothpastes prior to HP bleaching, including potassium nitrate toothpaste (PN) containing NaF, conventional sodium monofluorophosphate toothpaste (FT), arginine-based toothpastes (PA and SAN), or a toothpaste containing bioactive glass (NM). Color changes were determined using the CIE L*a*b* system (ΔE, ΔL, Δa, and Δb), and a roughness (Ra) analysis was performed before and after treatments. Surface microhardness (SMH) and cross-sectional microhardness (CSMH) were analyzed after treatment. Data were analyzed with repeated measures ANOVA for Ra, one-way ANOVA (SMH, ΔE, ΔL, Δa, and Δb), split-plot ANOVA (CSMH), and Tukey post hoc test (α<0.05). The relationship between the physical surface properties and color properties was evaluated using a multivariate Canonical correlation analysis. Color changes were statistically similar in the bleached groups. After treatments, SMH and CSMH decreased in PC. SMH increased significantly in the toothpaste groups vs the negative and positive control (NM > PA = SAN > all other groups) or decreased HP effects (CSMH). Ra increased in all bleached groups, with the exception of NM, which did not differ from the NC. The variation in the color variables (ΔL, Δa, and Δb) explained 21% of the variation in the physical surface variables (Ra and SMH). The application of toothpaste prior to dental bleaching did not interfere with the effectiveness of treatment. The bioactive glass based toothpaste protected the enamel against the deleterious effects of dental bleaching.

Regeneration Dynamics of White Spruce, Trembling Aspen, and Balsam Poplar in Response to Disturbance, Climatic, and Edaphic Factors in the Cold, Dry Boreal Forests of the Southwest Yukon, Canada

The southwestern region of the Yukon Territory of Canada has experienced an unprecedented spruce bark beetle outbreak (Dendroctonus rufipennis) and an increase in the frequency of forest fires that extend beyond historical trends and that have caused significant impacts on forest structure and composition. A Strategic Forest Management Plan (SFMP) for the Champagne and Aishihik Traditional Territory located in the southwest Yukon was implemented in 2004 in response to the spruce bark beetle (D. rufipennis) infestation and increased fire risk. The plan has recommended salvage harvesting of beetle-killed stands as a strategy to facilitate the development of a timber industry in the region and reduce the fire risk around communities. One of the objectives of the SFMP is to maintain, restore, or enhance forest regeneration, which requires an understanding of regeneration dynamics in the region. In this study, we investigated the regeneration of white spruce (Picea glauca), trembling aspen (Populus tremuloides), and balsam poplar (Populus balsamifera) and the relationship with climatic, disturbance, and edaphic factors within the region. Multivariate canonical correlation analysis was used to assess the weighted relationship between regeneration presence/absence and environmental factors, and negative binomial regression analysis was used to model regeneration abundance of white spruce, trembling aspen, and balsam poplar. We found that although regeneration of all three species responded positively to disturbance, the broadleaved species occupied disturbed plots at higher ratios than white spruce. Regeneration of broadleaved species was higher in open sites with exposed aspects, indicating a preference for warmer sites with higher solar radiation inputs. These findings support the hypothesis that if fire increased in the region with the warmer climate predicted by the Intergovernmental Panel on Climate Change, then the region will probably experience an increase in broadleaved species, leading to a more heterogeneous landscape.