This document is part of a global investigation that aims to establish best practices in usability testing of mobile applications, that fit the specific needs of persons with cognitive disabilities. The motivating factor is to improve the quality of life of people with special needs. As a first step, we want to discover what are the skills of people with DS (DS) when using a mobile device. Thanks to its direct manipulation interaction style, multi-touch technology is the ideal mechanism for learning activities with a view to the social inclusion of people with DS. This paper investigates the most common touchscreen gestures on commercial existing software. A commercial analysis was carried out to discover the touch screen gestures used by 103 free software Apps running on a mobile touch screen tablet of 11 where the applications run”. The commercial analysis showed that most applications support tap and drag operations on multi-touch technology. Additionally, the research sought to discover the adults with DS (19–54 years of age) ability to perform other gestures on multi-touch surfaces. A DS user skill study was performed to assess the ability of this user segment to interact with multi-touch surfaces. The analysis involved 53 participants, aged between 19 and 54 years, from two vocational training centers attended by people with DS in Madrid. Authors used the Gesture Games App for experimenting with multi-touch gestures such as tap, double tap, long press, drag, scale up, scale down, and one-finger rotation. Tap, double tap, and drag were the three gestures that the most participant could use. In contrast, participants had difficulty performing one-finger rotation and long press gesture. Our statistical analysis showed that the ability to perform each gesture was independent of gender, age group, and previous experience with touchscreen of a participant.