Substance abuse is a progressive global epidemic requiring a complex multisystem approach to improve patient outcomes. While many studies have sought to evaluate outcomes of chronic substance abuse, there remains a paucity of literature to characterize the cardiovascular outcome of acute poisoning. We sought to evaluate the correlation between illicit drug poisoning and dysrhythmia. Objective: A composite database of National Inpatient Sample (NIS) for 2016 and 2017 was queried using ICD-10 codes[RG1] to identify patients with poisoning from several commonly abused substances including: cannabis, cocaine, heroin, amphetamines, hallucinogens, and LSD. A propensity weighted logistic regression analysis was performed controlling for age, gender, and comorbidities. Propensity weighted cohorts were compared for correlation with dysrhythmias [atrial fibrillation/flutter (AF/AFL), sick sinus syndrome (SSS), bradyarrhythmia, AV block (AVB1, AVB2, CHB), supraventricular tachycardia (SVT), ventricular tachycardia (VT), and ventricular fibrillation (VF)]. [RG1]Were ICD-10 codes available in 2016, 2017? The study cohort of 22,485 patients with hospitalization forillicit drug poisoning was evaluated.Average age was 40+ 0.2 years, 32% of whom were female. A propensity weighted logistic regression model using each dysrhythmia category as a dependent variable was performed using Stata 17.0 controlling for age, gender, and comorbidity (presence of AICD, Pacemaker, history of chronic heart failure, diabetes, ischemic stroke, COPD, PVD, CKD, OSA, hypertension, CAD). Using a Bonferroni correction for 15 variables, a p value threshold of 0.003 was used. As covariates were chosen based on prior available evidence to suggest harm, negative Z statistics were assumed to be erroneous. [RG1] Cannabis poisoning was found to have a strong correlation to bradyarrhythmia, AVB1. Cocaine poisoning was found to be strongly associated with SSS, AF/AFL, bradyarrhythmia, AVB1, AVB2, CHB, SVT, VF, and VT (Table 1). [RG1]These should be under methods. Patients with cannabis and cocaine poisoning were found to be strongly correlated with concurrent dysrhythmia.