This work analyzes the transmission line characteristics of a plasmonic metal-insulator-metal (MIM) waveguide and a square ring resonator (SRR) for dual band applications. The MIM-SRR-based bio-sensor using 3-Aminopropyl triethoxy silane (APTES) and titanium dioxide ( T i O 2 ) as a precursor material are proposed and investigated in this paper. The MIM waveguide characteristics such as propagation length and effective refractive index have been obtained using the finite differential time domain (FDTD) solver of CST studio suite. The MIM-based SRR band-pass filter was designed and analyzed at 1300 nm (230.6 THz) and 1600 nm (187.37 THz) wavelengths. In this work, the bio-compatibility material T i O 2 is used as an agent of bio-molecules detection, and APTES is used as a linker between silicon dioxide and T i O 2 . The proposed MIM-SRR- T i O 2 -based bio-sensor is operated at 1320 nm (227.115 THz) and 1630 nm (183.922 THz). The proposed MIM-SRR-APTES- T i O 2 bio-sensor is operating at dual pass bands of 1415 nm (211.867 THz) and 1762 nm (170.143 THz). The proposed MIM-SRR-APTES- T i O 2 has a Q -factor of 22.353 and 20.655 and a sensitivity of 571.02 and 877.86 nm/RIU at 1415 and 1762 nm, respectively. APTES and T i O 2 are responsible for detecting cervical cancer, which is generally observed in woman. The scalability and multiplexing capability of semiconductor-based technology, silicon photonic ring resonators, are promising analytical tools for detecting various sensing applications. The overall size of the proposed bio-sensor is 1200 n m × 300 n m × 60 n m .