The author presents an effective method for computation of the transient response of multiple nonuniform transmission lines. This time-domain analysis technique can predict reflections and crosstalk. The proposed spectral technique is used to transform partial differential equations describing a system of transmission lines into a set of linear ordinary differential equations, which can be solved with one of the many well-developed integration techniques. Numerical experiments performed with the prototype program showed that the method can solve specific problems (lossless, uniform lines) just as fast as less general methods based on modal analysis exploiting the particular properties of lines.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>