Multiple Surveys Research Articles

Do Surveys Change Behaviours?

Abstract It is well known that being observed can change our behaviour. Alexandru Cernat and Florian Keusch used digital trace data to see whether taking part in multiple political surveys made participants more interested in news and politics

Changes in Child Discipline Strategies in Iran During the Outbreak of COVID-19.

During the prolonged COVID-19 pandemic, anxiety and depression were common among caregivers and parents more prone to adopt harsh disciplinary techniques when angry or stressed. The purpose of this study was to investigate if there are any differences in parents’ disciplinary strategies following social distancing efforts during the COVID-19 pandemic. An online questionnaire was completed by a convenience sample of parents (N = 605) and mothers (n = 533; 88.1%) aged 37.80 years old (SD = 5.66; range = 20–59) who lived with children aged 6–12 years in Iran during the COVID-19 pandemic. Iran's Multiple Indicator Demographic and Health Survey questionnaire was used to gauge child discipline. There was an increase in shaking (1.8%), shouting and yelling (15.5%). The findings of this study serve as a reminder to researchers and government officials that child abuse and violence are more likely to occur during stressful times and provide the scientific foundation for the development of tailored psychological treatment.

Teenage bicyclists' perceptions toward automated vehicles and their associated traffic infrastructure: A focus group discussion

Automated vehicles (AVs) can improve traffic safety for vulnerable road-users like bicyclists. It is most likely that current young people will be the ones to use these vehicles and interact with them. However, very few studies have focused on bicyclist-AV interaction, with little to no inclusion of teenage bicyclists. This research used a virtual focus group study with 25 teenage bicyclists in six groups. Participants were presented with potential designs of infrastructures and communicating interfaces, they discussed pros and cons for each design, and answered multiple surveys. Overall, teenage bicyclists showed positive perceptions toward AVs. They preferred spacious lanes for bicyclists and physical barriers separating AVs and bicyclists. Teenagers chose visual interfaces with familiar icons; nevertheless, they recommended both visual and audible interfaces to ensure bicyclists’ attention and address the need of visually and audibly impaired populations. Future researchers and stakeholders will be benefited from the methodology and outcomes of this research.

Activity of stygobionts in spring habitats: behavioral, ecological and evolutionary insights

Cave-dwelling animals might be regarded as dead-end points when it comes to their evolution and habitat exploitation. However, in the past different observations of the olms’ typical troglomorphic populations have been reported for springs of Venetia Giulia, along with a community rich in stygobionts (Bressi et al. 1999; Stoch 2017). The aim of this work is to point out the non-random active use of surface habitats by this community, providing a comparison with the occurrence observed in caves and performing an assessment of factors favouring ecotone habitats exploitation. Since 2020 we started multiple day and night surveys of olms in both 71 springs and 11 caves. Each spring and cave habitat monitored has been characterised by respect to abiotic and biotic features, including planktonic and benthic prey availability. Additionally, cave and spring populations of Troglocaris sp. were tested to determine whether they showed any behavioral difference regarding their response to light stimuli and predatory cues, as potential adaptations to the different conditions found in the two habitats. We used 34 individuals sampled from three springs and 24 from two caves of the Italian karst. We detected the olm at least once in 12 springs, with a maximum of 9 individuals occurring together. Detection probability in springs and caves was similar. Spring habitats provided higher density of potential prey available. Olms seem to prefer springs without predator fish and temporary hydroperiod. We recorded in one spring a larva of 3.5 cm which could be the smallest ever recorded in the field. Preliminary results of the behavioral experiments show no susceptibility to light neither for spring nor cave populations of Troglocaris sp., as for chemical cues we expect a difference in reactivity depending on the habitat of origin of the shrimp, consistently with the top predator present. We suggest that epigean habitats and borders with surface may have an underestimated importance for animals adapted to subterranean environments (Manenti and Piazza 2021), including the olm. Further studies focusing on the ipogean community which actively exploits spring habitats are underway, with the aim of determining the diel occupation of these complex ecotones.

IMPACT (Information Medically Pertinent in Acute Computed Tomography) requests: Delphi study to develop criteria standards for adequate clinical information in computed tomography requests in the Australian emergency department.

Inadequate clinical information in medical imaging requests negatively affects the clinical relevance of imaging performed and the quality of resultant radiology reports. Currently, there are no published Australian guidelines on what constitutes adequate clinical information in computed tomography (CT) requests. This study aimed to determine specific items of clinical information radiologists require in CT requests for acute chest, abdomen and blunt trauma examinations, to support optimal reporting. A panel of 24 CT-reporting consultant radiologists participated in this e-Delphi consensus study. Panellists undertook multiple online survey rounds of open-ended, dichotomous and Likert scale questions, receiving feedback following each. Round 1 responses formulated lists for each CT examination. Round 2 set a threshold of 80% agreement after dichotomous scoring. Round 3 accepted items which averaged 4 or more on a 5-point Likert scale. Round 4 required panellists to rank items within the aggregated, accepted lists, based on panellists' perceived level of usefulness. The large numbers of round 1 items (chest: 101, abdomen: 76, blunt trauma: 80) were rationalised and grouped into categories to facilitate efficiency during subsequent rounds. Twenty-three chest, 24 abdomen and 17 blunt trauma items met the 80% agreement threshold in round 2. Items below threshold were included in round 3; numbering 44, 19 and 23 for chest, abdomen and blunt trauma, respectively. Through the e-Delphi process, we formulated clinical information criteria standards for three CT types. The developed standards will guide Australian referrers in providing adequate clinical information in CT requests, to support optimal reporting, diagnosis and treatment.

Caves as evolutionary dead end? The journey of the stygobiont isopod Monolistra pavani toward sunlight

Monolistra are stygobiont isopods spread in numerous karst areas from the south-eastern parts of Dinaric karst to south-eastern Switzerland. They inhabit different typologies of groundwater habitats from lentic to lotic ones where they can be particularly important in terms of biomass. M. pavani is a steno-endemic species that was reported only for a single cave system in Lombardy (Italy). From October 2018 to March 2022, we performed multiple surveys in the subterranean system and in its surrounding springs recording abundance and distribution of the species. In December 2018 we discovered three spring populations/subpopulations of M. pavani in which pigmented individuals also occurred. We performed UV and infrared spectroscopy to evidence potential differences in the signals related to C-C bonds of the aromatic ring of the melanin molecules between cave and spring individuals. In 2020, we also compared circadian rhythm and responses to light stimuli of cave and spring individuals. Occurrence of M. pavani in springs was regular and associated to specific spring microhabitats; individuals were active both during day and during night. Nor spring and cave individuals avoid light stimuli. Circadian rhythm analyses revealed that individuals from springs are more active than those from cave, showing higher activity during day than during night. The 20% of spring individuals are pigmented, and eumelanin occurs in dark individuals. Our results suggest the possible ongoing adaptation to surface habitats at the border with groundwater in a species considered as a strict stygobiont. Molecular analyses on the population relationships are currently ongoing.

Groundwater invertebrates and droughts: resistance in stygobiont isopods and planarians

In surface freshwater habitats water level can be strongly variable and benthic invertebrates are usually adapted to cope with hydrological variability. Groundwater habitats are usually more stable, even if in sites at the interface with the vadose zone, in epikarst streams and dripping pools hydroperiod may vary. Adaptations to survive droughts are thus likely to have been developed also by groundwater-dwelling animals. However very few studies have been performed to assess stygobiont resistance to dryness. They involve mainly the amphipods of the genus Niphargus and Stygobromus; one case is reported for a triclad of the genus Atrioplanaria. Here we describe cases of resistance to drying in stygobiont planarians of the genus Dendrocoelum and the in the isopod Monolistra pavani. Since 2016 we performed multiple surveys in 53 caves in Italy and Switzerland, sampling different stable and unstable groundwater environments. Stygobionts were searched visually and by distressing the substrate. When we detected stygobionts in dry sectors of a cave, we observed their features and behaviours, we pictured them, and we tried to rinse them. We rinsed M. pavani individuals in small plastic tanks and recorded the time of reactivation. During the surveys we recorded a Dendrocoelum planarian encapsulated in a thick mucus layer on the substrate of a dry subterranean stream. When placed in water the planarian started gliding slowly and reached a length of 18 mm. During the drought of January-April 2022, we detected individuals of M. pavani in dry areas of two different caves. 72% of the individuals were able to reactivate. Time to reactivate ranged between 0 s to 30 s. We recorded living M. pavani individuals that were able to reactivate themselves even after 39 days of drought. Our observations provide new insights into the natural history of groundwater-dwelling invertebrate taxa which global climatic changes increase the risk of drought occurrence in subterranean environments.

A framework for continuation of digitalization in construction: a PLS-SEM approach

PurposeIndian construction firms are falling behind in the use of digital technology in the workplace, and this study aims to give a framework and assess the role of enablers in the implementation and continuing digitalization of the Indian construction sector.Design/methodology/approachAn exploratory qualitative research technique is used in this article, and multiple detailed interviews and surveys are done with professionals from the industry and academia. To conclude the significance and relevance of the different constructs and indicators, the partial least square-structural equation modeling (PLS-SEM) approach is used.FindingsBarriers are essential enablers for effective implementation, while success factors are important drivers for the successful continuance of digitalization in the construction sector. However, stakeholders' perceived benefit has a substantial role in both implementation and continuance.Research limitations/implicationsIn this research paper, the scope of this investigation for a generalized exploratory study is restricted to construction firms within India. Further, a rigorous longitudinal study may also be performed to examine the subjectivity of the responses in order to ensure digital continuation. This study identifies limited manifest indicators. Additional indications, however, may be included based on the other company's resources, structure and geographic location.Practical implicationsThe study's findings have two implications. In the beginning, it gives a direction to the construction sector by highlighting the framework in which implementation and continuance both should have to be executed, and this is the critical area for the successful continuance of digitalization in construction. Second, the research shows that the digitalization process is similar to the adoption of innovation, in which the deployment and persistent use of the new technology are important for facilitating the transformation.Originality/valueIn two respects, the study is distinctive. To begin, this is one of the limited efforts to comprehend digitalization from the Indian perspective. Second, the study reveals that the PLS-SEM approach can be effectively used in the developing subject of the construction digitalization concept.

Organizational Social Capital and Performance Information use: The Mediating Role of Public Service Motivation

This article examines the mediating role of public service motivation (PSM) between organizational social capital and performance information use. This topic is worth studying since it allows to understand how organizational level factors and individual level traits interact. Using a multiple informant survey distributed to county managers in Florida, this article finds support that organizational social capital is an important predictor of performance information use, and that this relationship is mediated by the role of PSM. The article concludes with recommendations on how to capitalize on these internal resources for the effective implementation of performance management reforms and practices.

Time-lapse data matching using a recurrent neural network approach

Time-lapse seismic data acquisition is an essential tool to monitor changes in a reservoir due to fluid injection, such as CO2 injection. By acquiring multiple seismic surveys in the exact same location, the authors can identify the reservoir changes by analyzing the difference in the data. However, such analysis can be skewed by the near-surface seasonal velocity variations, inaccuracy, and repeatability in the acquisition parameters, and other inevitable noise. The common practice (cross equalization) to address this problem uses the part of the data in which changes are not expected to design a matching filter and then apply it to the whole data, including the reservoir area. Like cross equalization, the authors train a recurrent neural network (RNN) on parts of the data excluding the reservoir area and then infer the reservoir-related data. The RNN can learn the time dependency of the data, unlike the matching filter that processes the data based on the local information obtained in the filter window. The authors determine the method of matching the data in various examples and compare it with the conventional matching filter. Specifically, we start by demonstrating the ability of the approach in matching two traces and then test the method on a prestack 2D synthetic data. Then, the authors verify the enhancements of the 4D signal by providing reverse time migration images. The authors measure the repeatability using normalized root-mean-square and predictability metrics and find that, in some cases, our proposed method performed better than the matching filter approach.

The heritability of BMI varies across the range of BMI-a heritability curve analysis in a twin cohort.

The heritability of traits such as body mass index (BMI), a measure of obesity, is generally estimated using family and twin studies, and increasingly by molecular genetic approaches. These studies generally assume that genetic effects are uniform across all trait values, yet there is emerging evidence that this may not always be the case. This paper analyzes twin data using a recently developed measure of heritability called the heritability curve. Under the assumption that trait values in twin pairs are governed by a flexible Gaussian mixture distribution, heritability curves may vary across trait values. The data consist of repeated measures of BMI on 1506 monozygotic (MZ) and 2843 like-sexed dizygotic (DZ) adult twin pairs, gathered from multiple surveys in older Finnish Twin Cohorts. The heritability curve and BMI value-specific MZ and DZ pairwise correlations were estimated, and these varied across the range of BMI. MZ correlations were highest at BMI values from 21 to 24, with a stronger decrease for women than for men at higher values. Models with additive and dominance effects fit best at low and high BMI values, while models with additive genetic and common environmental effects fit best in the normal range of BMI. We demonstrate that twin and molecular genetic studies need to consider how genetic effects vary across trait values. Such variation may reconcile findings of traits with high heritability and major differences in mean values between countries or over time.

The POKEMON Speckle Survey of Nearby M Dwarfs. I. New Discoveries

M dwarfs are favorable targets for exoplanet detection with current instrumentation, but stellar companions can induce false positives and inhibit planet characterization. Knowledge of stellar companions is also critical to our understanding of how binary stars form and evolve. We have therefore conducted a survey of stellar companions around nearby M dwarfs, and here we present our new discoveries. Using the Differential Speckle Survey Instrument at the 4.3 m Lowell Discovery Telescope, and the similar NN-EXPLORE Exoplanet Stellar Speckle Imager at the 3.5 m WIYN telescope, we carried out a volume-limited survey of M-dwarf multiplicity to 15 parsecs, with a special emphasis on including the later M dwarfs that were overlooked in previous surveys. Additional brighter targets at larger distances were included for a total sample size of 1070 M dwarfs. Observations of these 1070 targets revealed 26 new companions; 22 of these systems were previously thought to be single. If all new discoveries are confirmed, then the number of known multiples in the sample will increase by 7.6%. Using our observed properties, as well as the parallaxes and 2MASS K magnitudes for these objects, we calculate the projected separation, and estimate the mass ratio and component spectral types, for these systems. We report the discovery of a new M-dwarf companion to the white dwarf Wolf 672 A, which hosts a known M-dwarf companion as well, making the system trinary. We also examine the possibility that the new companion to 2MASS J13092185-2330350 is a brown dwarf. Finally, we discuss initial insights from the POKEMON survey.

The Diversity and Abundance of Soft Rot Pectobacteriaceae Along the Durance River Stream in the Southeast of France Revealed by Multiple Seasonal Surveys.

Although irrigation water is frequently assessed for the presence of plant pathogens, large spatial and temporal surveys that provide clues on the diversity and circulation of pathogens are missing. We evaluate the diversity of soft rot Pectobacteriaceae (SRP) of the genera Dickeya and Pectobacterium over 2 years in a temperate, mixed-use watershed. The abundance of isolated strains correlates with the agricultural gradient along the watershed with a positive correlation found with temperature, nitrate, and dissolved organic carbon water concentration. We characterized 582 strains by amplification and sequencing of the gapA gene. Multilocus sequence analysis, performed with three housekeeping genes for 99 strains, and core genome analysis of 38 sequenced strains, confirmed for all the strains but one, the taxonomic assignation obtained with the sole gapA sequence. Pectobacterium spp. (549 isolates) were far more abundant than Dickeya spp. (33 isolates). Dickeya spp. were only observed in the lower part of the river when water temperature was >19°C, and we experimentally confirmed a decreased fitness of several Dickeya spp. at 8°C in river water. D. oryzae dominates the Dickeya spp. and P. versatile and P. aquaticum dominate the Pectobacterium spp., but their repartition along the watershed was different, with P. versatile being the only species regularly recovered all along the watershed. Excepting P. versatile, the Dickeya and Pectobacterium spp. responsible for disease outbreak on crops were less abundant or rarely detected. This work sheds light on the various ecological behaviors of different SRP types in stream water and indicates that SRP occupation is geographically structured.

Farming Systems, Food Security and Farmers' Awareness of Ecosystem Services in Inland Valleys: A Study From Côte d'Ivoire and Ghana

Inland valleys (IVs) in West African countries have increasingly been used for crop production, including rice cultivation. Though it is widely assumed that IVs have a high potential to contribute to food security of West African countries, a comprehensive assessment of farming systems addressing agricultural, institutional, food security, poverty, and ecosystem indicators is still lacking. This study characterizes IVs' smallholder farm households at the regional and farm type level using Rural Household Multiple Indicator Survey (RHoMIS) data collected from 733 randomly selected farm households in four agro-ecological regions, i.e., Bouaké and Gagnoa in Cote d'Ivoire, and Ahafo Ano North and Ahafo Ano South in Ghana. A farm typology is developed, and farm households are characterized with regard to demographic, agricultural, economic, and institutional indicators. Furthermore, farm households' food security and poverty status, and the importance of rice in the portfolio of crops, is assessed. Finally, farmers' awareness of different ecosystem services (ES) for their food security is examined. Four farm types are identified, i.e., farmers who rent all the land cultivated, farmers who own some land and rent extra land, farmers who own and cultivate all their land, and farmers cultivating only a part of the land they own. We find that the variation in farm households' demographic, economic, and institutional characteristics is greater between regions than within regions. Crop production, either for direct consumption or marketing, especially rice production, is the main contributor to daily energy intake, followed by wild food consumed. Still, a substantial percentage of the farm households (16–38%) in all regions cannot meet minimum daily energy requirements. Farmers of all farm types, and in all regions, attach high relevance to IVs' provisioning ES, particularly the ability to provide food. A majority of farmers in all regions highlighted the relevance of regulating ES, including climate regulation, water storage, and groundwater values for their wellbeing. In contrast, farmers attached relatively lower relevance to cultural ES. Interventions to improve national rice production need to acknowledge and preserve the diversity ES that IVs provide to smallholder farm households.

Religion in the Twenty-First Century

Religion in the Twenty-First Century

Morphine Equianalgesic Dose Chart in the Emergency Department.

Morphine Equianalgesic Dose Chart in the Emergency Department.

The origin of close massive binaries in the M17 star-forming region

Context.Spectroscopic multiplicity surveys of O stars in young clusters and OB associations have revealed that a large portion (∼70%) of these massive stars (Mi > 15M⊙) belong to close and short-period binaries (with a physical separation of less than a few astronomical units). Follow-up VLT(I) high-angular-resolution observations led to the detection of wider companions (up tod ∼ 500 au), increasing the average companion fraction to > 2. Despite the recent and significant progress, the formation mechanisms leading to such close massive multiple systems remain to be elucidated. As a result, young massive close binaries (or higher-order multiple systems) are unique laboratories for determining the pairing mechanism of high-mass stars.Aims.We present the first VLTI/GRAVITY observations of six young O stars in the M17 star-forming region (≲1 Myr) and two additional foreground stars. VLTI/GRAVITY provides theK-band high-angular-resolution observations needed to explore the close environment of young O-type stars, and, as such, offers an excellent opportunity to characterise the multiplicity properties of the immediate outcome of the massive star formation process.Methods.From the interferometric model fitting of visibility amplitudes and closure phases, we search for companions and measure their positions and flux ratios. Combining the resulting magnitude difference with atmosphere models and evolutionary tracks, we further constrain the masses of the individual components.Results.All six high-mass stars are in multiple systems, leading to a multiplicity fraction of 100% and yielding a 68% confidence interval of 94–100%. We detect a total of nine companions with separations of up to 120 au. Including previously identified spectroscopic companions, the companion fraction of the young O stars in our sample reaches 2.3 ± 0.6. The derived masses span a wide range, from 2.5 to 50M⊙, with a great tendency towards high-mass companions. However, we do not find a significant correlation between the mass of the companions and their separation.Conclusions.While based on a modest sample, our results clearly indicate that the origin of the high degree of multiplicity is rooted in the star formation mechanism of the sample stars. No clear evidence for one of the competing concepts of massive star formation (core accretion or competitive accretion) could be found. However, given that we find all of the companions within ∼120 au, our results are compatible with migration as a scenario for the formation of close massive binaries.

A Preliminary Study on a Form of the 24-h Recall That Balances Survey Cost and Accuracy, Based on the NCI Method.

The 24-h recall (24HR) is a short-term dietary assessment instrument that is widely used in large-scale nutrition surveys. The number of survey days is critical in the accuracy of estimates. The multiple, repeated collection of 24HRs can yield reliable dietary intakes, whereas that is not always feasible due to staffing, equipment, financial, and temporal constraints. The NCI (National Cancer Institute) method was developed to address this limitation by using only within-person variance to calculate usual dietary intake. However, the performance of different forms of 24HRs based on the NCI method remains unclear. The aim of this study was to explore a form of 24HR based on the NCI method that can balance accuracy and survey cost. A total of 595 subjects completed 7 consecutive 24HRs in each season, for a total of 28 24HRs. The averages of the 28 collection days were defined as the reference value to compare the performance of 24HRs for two consecutive days (C2), three consecutive days (C3), two non-consecutive days (NC2), and three non-consecutive days (NC3) for estimating the dietary intakes of Chinese adults. The equivalence test was used to evaluate whether the estimates of scenarios NC2 and NC3 were equivalent. Additionally, the accuracy of a scenario of NC2 which included a weekend was compared to that of a scenario of NC2 which included two weekdays. All results of the 24HRs in each scenario were corrected by the NCI method. Bias/relative bias and mean bias/mean relative bias were used as measures of precision and accuracy, respectively. The results showed that the precision was similar among the four scenarios, while the accuracy relationship varied among the different dietary components. In general, scenario NC3 was the most accurate, followed by scenario NC2, which was close to the former. The form using non-consecutive days was more accurate than that using consecutive days, and the main factor affecting the accuracy of the 24HRs was the continuity between multiple survey days rather than the number of days. The means and major percentiles of energy, nutrients, and frequently consumed food in scenarios NC2 and NC3 were functionally identical. The accuracy of the scenario of NC2 which included a weekend was higher than that of scenario NC2, which consisted of only weekdays. The above results indicated that the adoption of two, non-consecutive 24HRs consisting of a weekend and a weekday to collect dietary data prior to correction by the NCI method, is a feasible approach to balancing survey costs and accuracy in large-scale nutrition surveys.

A comparison of pain, fatigue, and function between post-COVID-19 condition, fibromyalgia, and chronic fatigue syndrome: a survey study.

A growing number of individuals report prolonged symptoms following acute Coronavirus-19 (COVID-19) infection, known as post-COVID-19 condition (post-COVID-19). While studies have emerged investigating the symptom sequelae of post-COVID-19, there has been limited investigation into the characterization of pain, fatigue, and function in these individuals, despite initial reports of a clinical phenotype similar to fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME). This study aimed to characterize multiple symptom domains in individuals reporting post-COVID-19 and compare its clinical phenotype with those with FMS and CFS. A total of 707 individuals with a single or comorbid diagnosis of post-COVID-19, FMS, and/or CFS completed multiple surveys assessing self-reported pain, fatigue, physical and cognitive function, catastrophizing, kinesiophobia, anxiety, depression, dyspnea, and sleep quality. In all 3 diagnoses, elevated pain, fatigue, anxiety, depression, catastrophizing, and kinesiophobia were reported. Physical and cognitive function were similarly impacted among individuals with post-COVID-19, FMS, and CFS; however, individuals with post-COVID-19 reported lower pain and fatigue than FMS and CFS. The comorbid diagnosis of post-COVID-19 with FMS and/or CFS further exacerbated pain, fatigue, and psychological domains when compared with post-COVID-19 alone. In summary, individuals with post-COVID-19 report a symptom phenotype similar to FMS and CFS, negatively impacting cognitive and physical function, but with less severe pain and fatigue overall. These findings may help direct future investigations of the benefit of a biopsychosocial approach to the clinical management of post-COVID-19.

OzEAN Study to Collect Real-World Evidence of Persistent Use, Effectiveness, and Safety of Ozanimod Over 5 Years in Patients With Relapsing-Remitting Multiple Sclerosis in Germany.

Background:Ozanimod, a sphingosine 1-phosphate receptor 1 and 5 modulator, was approved as a disease-modifying therapy for active relapsing-remitting multiple sclerosis (RRMS) in 2020 and for active ulcerative colitis in 2021. Long-term, real-world studies in a nonselective population are needed. OzEAN is an ongoing study to assess the real-world persistent use, effectiveness, and safety of ozanimod and its impact on quality of life (QoL) in patients with RRMS over a 5-year period.MethodsThis prospective, noninterventional, postmarketing authorization study will enroll ~1,300 patients (≥18 years of age) with active RRMS. The decision to initiate ozanimod must have been made before and independent from study participation. Enrollment began in March 2021. Recruitment is ongoing and will last for 36 months across 140 sites in Germany. Treatment-naive patients or those having prior experience with a disease-modifying therapy receive oral ozanimod 0.92 mg/day after an initial dose escalation, per the summary of product characteristics recommendations, for up to 60 months. Persistence with ozanimod treatment (primary endpoint) is assessed at month 60. Secondary endpoints include additional physician-reported outcomes [persistence at earlier time points, annualized relapse rate, Expanded Disability Status Scale score, cognition (Symbol Digit Modalities Test), and incidence of adverse events], and patient-reported outcomes assessing patient satisfaction, adherence, and treatment modalities (Treatment Satisfaction Questionnaire for Medication, v1.4), disability (United Kingdom Neurological Disability Rating Scale), QoL (MSQOL-54 questionnaire), fatigue (Fatigue Scale for Motor and Cognitive Functions), and health economics [Work Productivity and Activity Impairment Questionnaire for Multiple Sclerosis (German v2.1); Multiple Sclerosis Health Resource Survey, v3.0]. A Multiple Sclerosis Documentation System with an internet-based e-health portal allows patients to view files and complete questionnaires. A safety follow-up will occur 3–8 months after the last ozanimod dose for patients who discontinue treatment early. Long-term results are anticipated after study completion in 2029. Yearly interim analyses are planned after enrollment has reached 25%.ConclusionThis is the first long-term, real-world study of ozanimod in patients with RRMS and, to our knowledge, the first noninterventional study utilizing a patient portal. These data will add to the safety/efficacy profile of ozanimod demonstrated in phase 3 trials.Clinical Trial RegistrationClinicaltrials.gov, identifier: NCT05335031.