Summary The case history of a 5-month-old Negro male infant with severe allergic tendencies complicated by infection has been presented. During his one hundred twenty-seven days of hospitalization he had clinical evidence of persistent upper respiratory infection, bronchitis, and thrush infection, three episodes of diarrhea, furunculosis of scalp and forehead with cervical lymphadenopathy and multiple subcutaneous abscesses. Throughout his stay he had a septic type of temperature elevation. Aside from frequent increase in leucocyte count, the only positive laboratory findings were cultures of Staph. aureus hemolyticus from the scalp furuncles and the subcutaneous abscess, and a predominance of Staphylococcus aureus in the throat culture. The possible exception is the report of Staph. anhemolyticus in the subculture of the first blood culture. In the light of subsequent events it seems probable that this was not a contamination as it was first considered. The child responded well to penicillin both times it was given.