Multiple Sessile Polyps Research Articles

Adenomas arising in Barrett's esophagus with adenocarcinoma: Report of three cases

Adenocarcinoma of the esophagus is a well known complication of Barren's esophagus, and results from a dysplasia-carcinoma sequence. This report describes 3 patients with adenomatous polyps arising in Barren's esophagus. One patient presented with multiple sessile or pedunculated polyps giving a polyposis appearance; the other two patients had single polyps associated with distinct adenocarcinoma arising in Barren's esophagus. Polyps consisted of adenomatous proliferation with adenocarcinoma in the 3 patients. Review of the literature identified twelve previously reported cases. These cases show that although rare, adenomas may arise in Barren's esophagus, and are most likely premalignant lesions such as other adenomas of the gastrointestinal tract.

Cronkhite Canada syndrome: case report with some features not previously described

A 69-year-old woman was admitted to our unit with a history of diarrhea and weight loss lasting 1 year. Diarrhea consisted of 10 to 15 bowel movements per day without either blood or mucus. No abdominal pain was present. Her weight had fallen from 100 kg to 70 kg the year prior to examination. She also noted gradual loss of hair and increasing thinness and brittleness of fingernails and toenails. On examination, the patient appeared to be overweight and dehydrated. She presented irregular alopecia and hair fell out upon being touched. There was brown pigmentation on the back of her hands and in the periorbital region, while the fingernails and toenails were atrophied with onychodystrophy. The remainder of the physical examination was unremarkable. Serum laboratory values were: white blood count 3100, hemoglobin 11 g, hematocrit 29%, and iron 49 /lgjdl. Electrolytes were: sodium 136 mmol/liter, and potassium 2.4 mmol/liter. Total proteins were 6 gjdl and albumin was 2.7 gjdl. Gastrin was 1000 pgjml (NV, 20 to 80) and there was no gastric acid production (MAO, 0); anti-gastric parietal cell antibody test was positive. Fecal microscopy and culture were negative for pathogens. Liver and kidney function tests were normal. Evaluation of endocrine function was normal. Secretion test of pancreatic function showed normal volume and bicarbonate output. Double-contrast barium enema and x-rays of the upper gastrointestinal tract revealed multiple filling defects of the colon and stomach. A small bowel enema did not show any polypoid lesions. The upper gastrointestinal endoscopy showed about 10 (0.5 to 3 cm) sessile polyps in the stomach (Fig. 1); the esophagus and the duodenum were free ofpolyps. The gastric mucosa between polyps was thin and pale, without erosions or ulcers. Colonoscopy revealed multiple (about 20) sessile and pedunculated polyps distributed throughout the colon. Histologic analysis of the gastric polyps showed the surface epithelium to be mostly flattened without ulceration

Polyposis of the Small Intestine in a Young Cat

A one year old female Foreign White cat is described with a history of six days of unthriftiness, anorexia, anaemia and depressed temperature. The necropsy revealed multiple sessile polyps in the jejunum. Histologically a hyperplasia of the crypt epithelium with an inflammation of the mucosa and submucosa was found. A comparison of polyposis in man, dogs and cats is made.

Spontaneous disappearance of fundic gland polyposis: Report of three cases

Three cases are reported in which multiple sessile polyps of the stomach disappeared spontaneously during the follow-up period from 9 to 34 mo. All of the patients were middle-aged females, and the distribution of the polyps was limited to the portion of the stomach with fundic glands. Histologic examination revealed simple hyperplasia of the fundic glands with microcysts. The macroscopic and histologic pictures were the same as the gastric lesions (“fundic gland polyposis”) found in cases with familial adenomatosis coli; however, colonic polyposis was not observed in our cases. The possible cause of the spontaneous disappearance of the polyps was discussed.

Endoscopic diagnosis of immunoproliferative small intestinal disease (IPSID).

Six patients with immunoproliferative small intestinal disease (IPSID), were examined endoscopically. The disease was found to involve the duodenum and jejunum and was characterized by the loss of the mucosal circular folds, a thickened cobblestone appearance of the mucosa and multiple sessile polyps. Ulceration of the mucosa was seen in one patient. A large ulcerated mass was seen in the third part of the duodenum in one patient.