Cultivating Suaeda salsa (S. salsa) is a promising strategy for the improvement and development of saline wastelands. However, the absence of a scientifically reasonable water and fertilizer management system has long hindered the large-scale improvement and utilization of saline wastelands. Therefore, we performed field experiments for two consecutive years to investigate the effects of water-nitrogen coupling on biomass, forage quality, salt absorption capacity, soil improvement effect, and economic benefits of S. salsa. The optimal water and nitrogen dosages for multi-objective optimization were determined using multiple regression and spatial analysis methods. Three irrigation levels were established for the experiment based on 0.35 (W1), 0.50 (W2), and 0.65 (W3) of the local ETo (Where ETo denotes the reference evapotranspiration calculated based on the FAO-56 recommended by the Food and Agriculture Organization). The three nitrogen application levels were 150 (F1), 250 (F2), and 350 (F3) kg ha−1 in the complete combination design. At the same nitrogen application level, the biomass and economic benefits of the W3 irrigation level were the highest. However, the forage quality, salt absorption capacity, salt reduction, and water productivity at the W3 irrigation level were lower than those at the W2 irrigation level, and the water productivity at the W1 irrigation level was the highest. At the same irrigation level, when the nitrogen application level was F2, the biomass, forage quality, salt absorption, salt reduction, and net profit, all reached their maximum values, and water productivity was the highest at the F3 level. The optimal amount of water and nitrogen applied for each parameter was different, so it was impossible to obtain the highest biomass, forage quality, salt absorption, salt reduction, water productivity, and net profit at the same time. Therefore, multi-objective optimization was needed, the optimal irrigation volume range was 3350.11–3485.97 m3 ha−1, and the nitrogen application rate range was 273.49–326.66 kg ha−1. These findings provide a scientific basis for the large-scale cultivation of S. salsa in extreme arid region, which is helpful for the improvement and utilization of saline-alkali land.