The subject of multiple primary carcinomas has been repeatedly studied and adequately reported. Shields Warren and Olive Gates3 recently published an excellent review of cases, 1,259 in all, in the literature as well as of their own sources. Since then a few other reports have appeared, increasing somewhat the total number of reported cases. Many and bizarre combinations of primary malignancies are included in these large sources, but the particular coincidence of neoplasms that the case to be discussed presented was not included. The reader is referred to the paper of Warren and Gates for an excellent analytical review of the subject to date. T. C., aged 64 years, was referred to the Cancer Division at Kings County Hospital, on June 8, 1934. His chief complaint was pain, of not more than seven weeks' duration, on the left side of his tongue which radiated toward his left ear and was aggravated by swallowing. For eight months previous to this he had been treated in the Medical Clinic for arteriosclerotic cardiorenal disease. His past history was irrelevant except for the fact that it showed that he had received treatment, in 1930, at another hospital for a laryngeal newgrowth, and that he had remained under the care of that institution until November, 1932. His family history was negative for carcinoma or other so-called “familial” diseases. A report from the other hospital stated that the patient had been treated in June, 1930, for an extrinsic carcinoma of the larynx reported pathologically as epidermoid carcinoma, transitionally Grade Two, moderately radiosensitive. He was given 28,000 mc.-hr. of radium externally to each side of his larynx and the equivalent of 760 mc.-hr. of radium treatment from gold seeds placed in the left pyriform sinus. At the time of his first visit to our Clinic, physical examination showed the following: A rather obese, adult, white male, aged 64 years. His heart, lungs, abdomen, and extremities were essentially negative except for moderate signs of arteriosclerosis. Laryngeal examination by one of us showed an essentially normal larynx. Both cords moved normally. There was no evidence of recurrent or residual growth, and very little evidence of scarring. On the middle third of the left lateral border of his tongue there was an indurated, ulcerated, neoplastic lesion, well demarcated. The tonsillar pillars and tongue base were not involved. Biopsy was reported by Dr. Hala, attending pathologist, as follows: “Section is one of tongue, including portion of the muscles. In some places the mucous lining is hypertrophied, with marked acanthosis and keratinization of the cells; elsewhere, there is ulceration, and the presence of numerous irregular islands of varied size consisting of large squamous epithelial cells showing here and there a tendency toward pearl formation. This growth infiltrates in some areas into the muscular zone. Diagnosis: Squamous-cell carcinoma of the tongue.”