The low order Taylor’s series expansion was employed in this study to estimate the reliability indices of the failure criteria for reliability-based design optimization of a linear static structure subjected to random loads and boundary conditions. By taking the advantage of the linear superposition principle, only a few analyses of the structure subjected to unit-loads are needed through the entire optimization process to produce acceptable results. Two structural examples are presented in this study to illustrate the effectiveness of the proposed approach for reliability-based design optimization: one deals with a truss structure subjected to random multiple point constraints, and the other conducts shape design optimization of a plane stress problem subjected to random point loads. Both examples were formulated and solved by the finite element method. The first example used the penalty method to reformulate the multiple point constraints as external loads, while the second example introduced an approach to propagate the uncertainty linearly from the nodal displacement vector to the nodal von Mises stress vector. The final designs obtained from the reliability-based design optimization were validated through Monte Carlo simulation. This validation process was completed with only four unit-load analyses for the first example and two for the second example.