Multiple Origins Research Articles

Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping.

Multiple embryonic origins give rise to forebrain oligodendrocytes (OLs), yet controversies and uncertainty exist regarding their differential contributions. We established intersectional and subtractional strategies to genetically fate map OLs produced by medial ganglionic eminence/preoptic area (MGE/POA), lateral/caudal ganglionic eminences (LGE/CGE), and dorsal pallium in the mouse brain. We found that, contrary to the canonical view, LGE/CGE-derived OLs make minimum contributions to the neocortex and corpus callosum, but dominate piriform cortex and anterior commissure. Additionally, MGE/POA-derived OLs, instead of being entirely eliminated, make small but sustained contribution to cortex with a distribution pattern distinctive from those derived from the dorsal origin. Our study provides a revised and more comprehensive view of cortical and white matter OL origins, and established valuable new tools and strategies for future OL studies.

Ice age-driven range shifts of diploids and expanding autotetraploids of Biscutella laevigata within a conserved niche.

Early studies of the textbook mixed-ploidy system Biscutella laevigata highlighted diploids restricted to never-glaciated lowlands and tetraploids at high elevations across the European Alps, promoting the hypothesis that whole-genome duplication (WGD) is advantageous under environmental changes. Here we addressed long-held hypotheses on the role of hybridisation at the origin of the tetraploids, their single vs multiple origins, and whether a shift in climatic niche accompanied WGD. Climatic niche modelling together with spatial genetics and coalescent modelling based on ddRAD-seq genotyping of 17 diploid and 19 tetraploid populations was used to revisit the evolution of this species complex in space and time. Diploids differentiated into four genetic lineages corresponding to allopatric glacial refugia at the onset of the last ice age, whereas tetraploids displaying tetrasomic inheritance formed a uniform group that originated from southern diploids before the last glacial maximum. Derived from diploids occurring at high elevation, autotetraploids likely inherited their adaptation to high elevation rather than having evolved it through or after WGD. They further presented considerable postglacial expansion across the Alps and underwent admixture with diploids. Although the underpinnings of the successful expansion of autotetraploids remain elusive, differentiation in B. laevigata was chiefly driven by the glacial history of the Alps.

Academic Filmmaking in the New Humanities. Video Essays.

The article provides an introduction to the second of a pair of special issues devoted to academic filmmaking, which contains ten video essays and prose guiding texts. The article describes the variety of filmmaking practice in the academy, and some of the venues where examples of the practice are published or exhibited. It gestures at the multiple origins of academic filmmaking with special reference to the tradition of the essay film, and finds a key reflexive moment in Eric S. Faden’s (prose) “Manifesto for Critical Media” (2008), which articulated the challenge of using “image, voice, pacing, text, sound, music, montage, rhythm” to create scholarly audiovisual work. The introduction goes on to set out the aims for the special issues, and to describe the contents of the video essays and some of the features, concerns or approaches shared between and across those contents. The video essays derive from fields including videographic criticism, anthropology, experimental cinema, and participatory and activist filmmaking.

Academic Filmmaking in the New Humanities

The article provides an introduction to the first of a pair of special issues devoted to academic filmmaking, which, apart from this introduction, contains eleven prose articles. The article describes the variety of filmmaking practice in the academy, and some of the venues where examples of the practice are published or exhibited. It gestures at the multiple origins of academic filmmaking with special reference to the tradition of the essay film, and finds a key reflexive moment in Eric S. Faden’s (prose) “Manifesto for Critical Media” (2008), which articulated the challenge of using “image, voice, pacing, text, sound, music, montage, rhythm” to create scholarly audiovisual work. The introduction goes on to set out the aims for the special issues, and to describe the contents of the eleven articles in the first issue and some of the features, concerns or approaches shared between and across those contents. The eleven articles deal with themes raging from academic filmmaking as activism, to vulnerability and embodiment, to the challenges of production and publishing, and of institutional legitimization.

Academic Filmmaking in the New Humanities. Articles. Introduction to the special issue.

The article provides an introduction to the first of a pair of special issues devoted to academic filmmaking, which, apart from this introduction, contains eleven prose articles. The article describes the variety of filmmaking practice in the academy, and some of the venues where examples of the practice are published or exhibited. It gestures at the multiple origins of academic filmmaking with special reference to the tradition of the essay film, and finds a key reflexive moment in Eric S. Faden’s (prose) “Manifesto for Critical Media” (2008), which articulated the challenge of using “image, voice, pacing, text, sound, music, montage, rhythm” to create scholarly audiovisual work. The introduction goes on to set out the aims for the special issues, and to describe the contents of the eleven articles in the first issue and some of the features, concerns or approaches shared between and across those contents. The eleven articles deal with themes raging from academic filmmaking as activism, to vulnerability and embodiment, to the challenges of production and publishing and of institutional legitimization.

Phylogeographic analysis reveals multiple origins of the desert shrub Reaumuria songarica in northern Xinjiang, involving homoploid and tetraploid hybrids.

Hybrid speciation plays an important role in species diversification. The establishment of reproductive isolation is crucial for hybrid speciation, and the identification of diverse types of hybrids, particularly homoploid hybrid species, contributes to a comprehensive understanding of this process. Reaumuria songarica is a constructive shrub widespread in arid Central Asia. Previous studies have inferred that the R. songarica populations in the Gurbantunggut Desert (GuD) originated from homoploid hybridizations between its eastern and western lineages and may have evolved into an incipient species. To further elucidate the genetic composition of different hybrid populations and to determine the species boundary of this hybrid lineage, we investigated the overall phylogeographic structure of R. songarica based on variation patterns of five cpDNA and one nrITS sequences across 32 populations. Phylogenetic analyses demonstrated that within the GuD lineage, the Wuerhe population evolved directly from ancestral lineages, whereas the others originated from hybridizations between the eastern and western lineages. PCoA and genetic barrier analysis supported the subdivision of the GuD lineage into the southern (GuD-S) and northern (GuD-N) groups. Populations in the GuD-S group had a consistent genetic composition and the same ancestral female parent, indicating that they belonged to a homoploid hybrid lineage. However, the GuD-N group experienced genetic admixture of the eastern and western lineages on nrITS and cpDNA, with some populations inferred to be allopolyploid based on ploidy data. Based on cpDNA haplotypes, BEAST analyses showed that the GuD-S and GuD-N groups originated after 0.5 Ma. Our results suggest that multiple expansions and contractions of GuD, driven by Quaternary climatic oscillations and the Kunlun-Yellow River tectonic movement, are important causes of the complex origins of R. songarica populations in northern Xinjiang. This study highlights the complex origins of the Junggar Basin flora and the underappreciated role of hybridization in increasing its species diversity.

Multiple origins of extra electron diffractions in fcc metals.

Diffuse intensities in the electron diffraction patterns of concentrated face-centered cubic solid solutions have been widely attributed to chemical short-range order, although this connection has been recently questioned. This article explores the many nonordering origins of commonly reported features using a combination of experimental electron microscopy and multislice diffraction simulations, which suggest that diffuse intensities largely represent thermal and static displacement scattering. A number of observations may reflect additional contributions from planar defects, surface terminations incommensurate with bulk periodicity, or weaker dynamical effects.

Whole-genome sequencing of Ganzi horse reveals the genetic diversity and provides unique insights into its plateau adaptation

Ganzi horse is distributed in the Ganzi Tibetan Autonomous Prefecture. As we all know, this region on the southeast of the Tibetan Plateau is characterized by low oxygen levels, low atmospheric pressure, and intense ultraviolet light. The extreme environment causes the genomic variation of plateau animals for environmental adaptation. At present, the genetic diversity and the genetic basis of high-altitude adaptation of Ganzi horses remain unclear. Here, an extensive genetic analysis was conducted utilizing whole-genome sequencing data from 145 individual horses. The analysis of autosomal genetic diversity confirmed that Ganzi horses had experienced low intensity artificial selection and had high genetic diversity. Examination of mitochondrial DNA information from whole-genome sequencing data revealed multiple maternal origins for Ganzi horses. Further, four different selective scanning methods were used to identify positive selected genomic regions and genes associated with high-altitude adaptation. We identified genes associated with altitude adaptation at selection windows in Ganzi horses, such as EPAS1, ABTB2, RHOQ, and TMEM247. Notably, EPAS1 and OR52A1J gene exhibited high select signal values, different nucleotide diversities, and haplotype patterns, and missense mutations in EPAS1 (A > T) and OR52A1J (C > T) were found to be more frequent in high-altitude horses. Moreover, our research illuminated significant gene flow between Ganzi and Chaidamu horses, which may be related to the formation of Ganzi horses. In general, these findings not only enhance our understanding of this unique native breed but also further our understanding of Ganzi horse's high-altitude adaptation.

Macrophages of multiple hematopoietic origins reside in the developing prostate.

Tissue-resident macrophages contribute to the organogenesis of many tissues. Growth of the prostate is regulated by androgens during puberty, yet androgens are considered immune suppressive. In this study, we characterized the localization, androgen receptor expression and hematopoietic origin of prostate macrophages, and transiently ablated macrophages during postnatal prostate organogenesis in the mouse. We show that myeloid cells were abundant in the prostate during puberty. However, nuclear androgen receptor expression was not detected in most macrophages. We found Cx3cr1, a marker for macrophages, monocytes and dendritic cells, expressed in interstitial macrophages surrounding the prostate and associated with nerve fibers. Furthermore, we provide evidence for the co-existence of embryonic origin, self-renewing, tissue-resident macrophages and recruited macrophages of bone-marrow monocyte origin in the prostate during puberty. Our findings suggest that prostate macrophages promote neural patterning and may shed further light on our understanding of the role of the innate immune system in prostate pathology in response to inflammation and in cancer.

Mineralogy and rare earth elements spatial distribution in the carboniferous rocks of the eastern El Galala El Bahariya, Egypt

The Carboniferous rocks in the eastern part of El Galala El Bahariya were investigated using integrated field and laboratory techniques to determine their mineralogy, rare earth elements (REEs) distribution, and structural lineament density. The succession is mainly composed of argillaceous and minor arenaceous rocks, exhibiting variations in lithology across the study area. The essential minerals of these rocks are quartz, kaolinite, and illite. The accessory minerals include microcline, gypsum, anhydrite, halite, barite, hematite, pyrite, anatase and gibbsite, in addition to, the radioactive and REEs-bearing minerals such as uranophane, xenotime, monazite, and zircon. These minerals are reported in the rocks of the study area for the first time. The types, forms, habits, and modes of occurrence of the recorded minerals indicate multiple origins: allogenic–authigenic, and primary-secondary. REEs in the rocks exhibit enriched patterns with a negative Eu anomaly, likely due to low plagioclase content or and/or Eu removal by alteration processes. The distribution of REEs is influenced by textural attributes, with finer sediments in the southern part showing higher REEs content, ascribed to the high clay content and presence of gibbsite. The preferential mobility of LREEs is evident, explaining elevated LREEs/HREEs ratios in the rocks. Utilizing remote sensing techniques, lithological units and alteration zones were determined using decorrelation stretch and band ratio methods. The structural features, identified by Laplacian filter and edge enhancement, revealed the presence of NW–SE, N–S, and NE–SW faults that structurally regulate alteration zones and REEs distribution. These alteration zones are associated with clay minerals, REEs concentrations, and high lineament structure density. Spatial distribution maps highlight higher REEs concentrations in the southern part of the study area. These findings were validated using various analytical methods, including mineralogical and geochemical investigations, main component analysis, minimum noise fraction, decorrelation stretch, and spectral reflectance studies. They provide new insights into the REEs potential of the Carboniferous rocks and heighten our understanding of REEs genesis and distribution in the region.

Osteoclast-derived coupling factors: origins and state-of-play Louis V Avioli lecture, ASBMR 2023.

Coupling, the mechanism that controls the sequence of events in bone remodeling, is a fundamental theory for understanding the way the skeleton changes throughout life. This review is an adapted version of the Louis V Avioli lecture, delivered at the Annual Scientific Meeting of the American Society of Bone and Mineral Research in 2023. It outlines the history of the coupling concept, details how coupling is thought to occur within trabecular and cortical bone, and describes its multiple contexts and the many mechanisms suggested to couple bone-forming osteoblasts to the prior action of osteoclasts on the same bone surface. These mechanisms include signals produced at each stage of the remodeling sequence (resorption, reversal, and formation), such as factors released by osteoclasts through their resorptive action and through protein synthesis, molecules deposited in the cement line during the reversal phase, and potential signals from osteocytes within the local bone environment. The review highlights two examples of coupling factors (Cardiotrophin 1 and EphrinB2:EphB4) to illustrate the limited data available, the need to integrate the many functions of these factors within the basic multicellular unit (BMU), and the multiple origins of these factors, including the other cell types present during the remodeling sequence (such as osteocytes, macrophages, endothelial cells, and T-cells).

Growing Confidence and Remaining Uncertainty About Animal Consciousness

While the study of consciousness has had a controversial history and, until recently, a pessimistic prognosis, recent views within the neuroscientific community suggest that a maturing if incomplete scientific understanding of consciousness is close at hand. The purpose of this essay is to specify the major points on which in my opinion there is widespread though not universal agreement, as proposed benchmarks for the current state of consciousness research across the phylogenetic spectrum. Most published definitions of consciousness boil down to a focus on it as a process arising in a nervous system engaged with a body and its environment, giving rise to subjective (personal) experience. A broad consensus on the phenomenology of consciousness sees it consisting at a minimum of (1) awareness_ _and focused attention, (2) unity of perception, (3) qualitative variations in content, (4) mental causation, and (5) a sense of self. There is also broad agreement that the substrate of consciousness requires sizeable, complex nervous systems organized into several hierarchical levels of processing. Further insight is gained by reconstructing the evolution of subjective phenomenological experience ― most likely from multiple origins, hosted by a diversity of body and brain architectures, and diverging into markedly different forms across the animal kingdom. However, three major mysteries about phenomenological experience that remain unresolved are (1) the neurological correlates of consciousness, (2) the apparent gap between phenomenology and mechanism, and (3) the process that monitors the brain activity admitted into consciousness.

The “mythologies” of women at work, interrupted: feminist origins antenarratives from Harvard Business Review and Western University’s The Quarterly, Part I

Purpose The author aims to walk beside the singular privileged class of White women’s suffrage feminist origin story to (re)construct plausible feminist fragmented threads as antenarratives in the context of business management education. To accomplish this (re)assembling of threads, the author examined two North American business trade publications created and used within two business schools, Harvard University’s Harvard Business Review (HBR), established in 1922, and Western University’s The Quarterly Review of Commerce (The Quarterly), established in 1933. Design/methodology/approach The author carefully reviewed almost 4,000 articles from HBR and The Quarterly, focusing on 308 articles that addressed the experiences of complex women. With this subset of collected articles, the author highlighted overlooked details, accidents and errors, generating interest and curiosity about the emergence of these fragmented and paradoxical origins that align with Foucault's histories of errors. By grouping these narrative fragments into themes and conducting a critical discourse analysis that incorporated influences from the external environment, the author reconstructed plural feminist origins antenarratives. Findings The themes discovered, including women as consumers, explicit working women concerns, women as authors/coauthors, diversity and social justice initiatives, and women in higher education/training, are not merely descriptive observations. They are the building blocks for identifying and analyzing the power relations circulating among feminist origins antenarratives within management education circles. These antenarratives include shedding light on women working in capitalist contexts, the educational needs of business women, and men and naming (but not breaking) the “mythologies” of women at work. These findings are transformative to the understanding of plural feminist origins. Originality/value The uniqueness of this work lies in its threefold contributions: moving away from the notion of a singular feminist origin story and instead embracing the complexity of multiple, paradoxical and incomplete origins; shedding light on the spectrum of power relations – ranging from productive to oppressive – that shaped the experiences of women in two management educational circles during the first half of the 20th century; and introducing the concept of inflection points, which underscores the fluidity of knowledge.

The Multiple Cultural Origins of Contemporary Chinese Volunteer Spirit: A Life History Study

Community volunteers occupy a unique position, being at the margins of institutional systems but central to public life in communities. They play a crucial role in forming and maintaining primary-level social order. Through life history interviews that explore the spiritual world of community volunteers, this study proposes a typology of community actors: enthusiasts, devotees, the dissatisfied, and neutrals. The first two types broadly constitute what can be termed “community volunteers.” Analyzing the multiple cultural origins that give rise to proactive community actors reveals that the interplay of familial, individual, and danwei (work unit) consciousness is the fundamental driving force behind their engagement in public life. Actors carry the cultural weight of multiple contexts through their life practice, with community an intermediary structure between family and state. This exploration provides a new framework for understanding contemporary Chinese urban community volunteers and community governance, uncovering the consciousness and emotional structures embedded in individual actors by macro-social transformation and highlighting a historical path of primary-level governance modernization in China that is distinct from that of the West.

Live Free and Die: How Social Media Amplify Populist Vaccine Resistance

The COVID-19 pandemic led to over one million American deaths, disproportionately suffered by those who resisted vaccination by championing individual autonomy over the collective good. The article takes as its point of departure that vaccine resistance is a recurring phenomenon in U.S. history with multiple origins. Among these are the absence of a consistent approach to public health policy—the combined result of the absence of federal police power—and tensions between the public good and libertarian values. The latest instance of populist resistance was assisted by changes in the information system. Relying on several lines of research, we specify a model of group identification that highlights social media’s role in this latest eruption of opposition. A key element is an attentive public that selectively shares information based on reputational concerns. We test our model by applying frame analysis on a body of data drawn from U.S.-based news content and audience reactions on Facebook.

Evidence for human-caused founder effect in populations of Solanum jamesii at archaeological sites: II. Genetic sequencing establishes ancient transport across the Southwest USA.

The domestication of wild plant species can begin with gathering and transport of propagules by Indigenous peoples. The effect on genomic composition, especially in clonal, self-incompatible perennials would be instantaneous and drastic with respect to new, anthropogenic populations subsequently established. Reductions in genetic diversity and mating capability would be symptomatic and the presence of unique alleles and genetic sequences would reveal the origins and ancestry of populations associated with archaeological sites. The current distribution of the Four Corners potato, Solanum jamesii Torr. in the Southwestern USA, may thus reflect the early stages of a domestication process that began with tuber transport. Herein genetic sequencing (GBS) data are used to further examine the hypothesis of domestication in this culturally significant species by sampling 25 archaeological and non-archaeological populations. Archaeological populations from Utah, Colorado and northern Arizona have lower levels of polymorphic loci, unique alleles, and heterozygosity than non-archaeological populations from the Mogollon region of central Arizona and New Mexico. Principle components analysis, Fst values, and structure analysis revealed that genetic relationships among archaeological populations did not correspond to geographic proximity. Populations in Escalante, Utah were related to those on the Mogollon Rim (400 km south) and had multiple origins and significant disjunctions with those populations in Bears Ears, Chaco Canyon, and Mesa Verde sites. Movement of tubers from the Mogollon region may have occurred many times and in multiple directions during the past, resulting in the complex genetic patterns seen in populations from across the Four Corners region.

Diversity and distribution of bamboo-feeding true bugs in China.

The Bambusoideae subfamily, originating in the late Cretaceous, has evolved to include over 1500 species globally. Notably, China hosts the richest diversity of Bambusoideae, with 728 species documented. After a long period of coevolution, plenty of animals could feed on these plants rich in cellulose and lignin. As an important group of pests and participants in the ecosystem, bamboo-feeding true bugs (BFTBs, or bamboo-feeding Heteropteran insects) have attracted the attention of researchers. However, the diversity and distribution of BFTBs still lack systematic and generalized research. In this study, we reviewed the BFTBs in China and simulated the diversity pattern and the driving forces of this pattern. A list of 36 genera with 69 species of BFTBs in China was obtained through paper review and field surveys. And their bamboo-feeding habit had multiple independent origins. The spatial diversity pattern showed that the biodiversity hotspots of BFTBs are located in and around the tropics of southern China. Environmental driving force analysis showed that the minimum temperature of coldest month and annual precipitation were the dominant environmental factors shaping the spatial diversity of BFTBs. Our work quantified the diversity and distribution of BFTBs in China, providing fundamental data support for pest control and evolutionary research.

Detection and population genetic analysis of Aedes albopictus (Diptera: Culicidae) based on knockdown resistance (kdr) mutations in the Yangtze River basin of China

BackgroundAedes albopictus is an important vector of chikungunya, dengue, yellow fever and Zika viruses. Insecticides are often the most effective tools for rapidly decreasing the density of vector populations, especially during arbovirus disease outbreaks. However, the intense use of insecticides, particularly pyrethroids, has led to the selection of resistant mosquito populations worldwide. Mutations in the voltage-gated sodium channel (VGSC) gene are one of the main drivers of insecticide resistance in Ae. albopictus and are also known as “knockdown resistance” (kdr) mutations. Knowledge about genetic mutations associated with insecticide resistance is a prerequisite for developing techniques for rapid resistance diagnosis. Here, we report studies on the origin and dispersion of kdr haplotypes in samples of Ae. albopictus from the Yangtze River Basin, China; MethodsHere, we report the results of PCR genotyping of kdr mutations in 541 Ae. albopictus specimens from 22 sampling sites in 7 provinces and municipalities in the Yangtze River Basin. Partial DNA sequences of domain II and domain III of the VGSC gene were amplified. These DNA fragments were subsequently sequenced to discover the possible genetic mutations mediating knockdown resistance (kdr) to pyrethroids. The frequency and distribution of kdr mutations were assessed in 22 Ae. albopictus populations. Phylogenetic relationships among the haplotypes were used to infer whether the kdr mutations had a single or multiple origins; ResultsThe kdr mutation at the 1016 locus had 2 alleles with 3 genotypes: V/V (73.38%), V/G (26.43%) and G/G (0.18%). The 1016G homozygous mutation was found in only one case in the CQSL strain in Chongqing, and no 1016G mutations were detected in the SHJD (Shanghai), NJDX (Jiangsu) or HBQN (Hubei) strains. A total of 1532 locus had two alleles and three genotypes, I/I (88.35%), I/T (8.50%) and T/T (3.14%). A total of 1534 locus had four alleles and six genotypes: F/F (49.35%), F/S (19.96%), F/C (1.48%) and F/L (0.18%); S/S (23.66%); and C/C (5.36%). Haplotypes with the F1534C mutation were found only in Ae. albopictus populations in Chongqing and Hubei, and C1534C was found only in three geographic strains in Chongqing. Haplotypes with the 1534S mutation were found only in Ae. albopictus populations in Sichuan and Shanghai. F1534L was found only in HBYC. The Ae. albopictus populations in Shanghai were more genetically differentiated from those in the other regions (except Sichuan), and the genetic differentiation between the populations in Chongqing and those in the middle-lower reaches of the Yangtze River (Huber, Jiangsu, Jiangxi, and Anhui) was lower. Shanghai and Sichuan displayed low haplotype diversity and low nucleotide diversity. Phylogenetic analysis and sequence comparison revealed that the 1016 locus was divided into three branches, with the Clade A and Clade B branches bearing the 1016 mutation occurring mostly in Jiangsu and the Clade C branch bearing the 1016 mutation occurring mostly in Chongqing, suggesting at least two origins for 1016G. IIIS6 phylogenetic analysis and sequence comparison revealed that F1534S, F1534C and I1532T can be divided into two branches, indicating that IIIS6 has two origins; ConclusionsCombined with the distribution of kdr mutations and the analysis of population genetics, we infer that besides the local selection of pyrethroid resistance mutations, dispersal and colonization of Ae. albopictus from other regions may explain why kdr mutations are present in some Ae. albopictus populations in the Yangtze River Basin.

Multiple independent origins of the female W chromosome in moths and butterflies.

Lepidoptera, the most diverse group of insects, exhibit female heterogamy (Z0 or ZW), which is different from most other insects (male heterogamy, XY). Previous studies suggest a single origin of the Z chromosome. However, the origin of the lepidopteran W chromosome remains poorly understood. Here, we assemble the genome from females down to the chromosome level of a model insect (Bombyx mori) and identify a W chromosome of approximately 10.1 megabase using a newly developed tool. In addition, we identify 3593 genes that were not previously annotated in the genomes of B. mori. Comparisons of 21 lepidopteran species (including 17 ZW and four Z0 systems) and three trichopteran species (Z0 system) reveal that the formation of Ditrysia W involves multiple mechanisms, including previously proposed canonical and noncanonical models, as well as a newly proposed mechanism called single-Z turnover. We conclude that there are multiple independent origins of the W chromosome in the Ditrysia (most moths and all butterflies) of Lepidoptera.

Radical cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal sarcomatosis: Results from a reference center and considerations based on current evidence

IntroductionPeritoneal sarcomatosis is a rare disease, with multiple histological origins and poor overall prognosis. The option of radical cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is controversial. The results of a surgical team experienced in these procedures are analyzed and discussed based on the available evidence. MethodsStudy on a prospective database of patients with peritoneal sarcomatosis who underwent CRS and HIPEC, from 2016 to 2022, in a national reference center for sarcomas and peritoneal oncological surgery, who met the established inclusion/exclusion criteria. Results23 patients were included in the study, with a median age of 53 years (6−68). Recurrent/persistent clinical presentation predominated (78.3%). Visceral origin (including GIST and non-GIST peritoneal) accounted for 47.8% of patients, compared to 43.5% uterine and 8.7% retroperitoneal. The median PCI was 17 (3−36), with CC0 cytoreduction of 87%. Postoperative morbidity (Dindo Clavien III–IV) of 13%, with no postoperative mortality in the series. Overall survival and disease-free survival at 5 years were 64% and 34%, respectively. Histological grade was the most influential prognostic factor for survival. ConclusionsThe results of the series, with low morbidity, support the benefit of radical peritoneal oncological surgery in patients with peritoneal sarcomatosis after adequate selection, as long as it is performed in high-volume centers, experienced surgeons and expert multidisciplinary teams. However, the role of HIPEC remains to be demonstrated and pending future studies.