A new deinking method for paper recycling using a fluid-jet cavitation technique has been developed. An in-house, laboratory-scale device revealed that cavitation-jet treatment without deinking chemicals decreases ink and dirt content in deinked pulp. As the next step, a pilot-scale deinking device, 10 times larger than the laboratory device, was designed. The specifications of the pilot device were determined by experiments using the laboratory device. The pilot device was installed in a deinked pulp mill, and the effects of multijet nozzles within a reacting vessel, depending on consistencies of the deinked pulp, were investigated. The operation stability of the device was examined as well. The shape and size of an effective cavitation zone for ink detachment were changed by nozzle diameter and upstream pressure of the jet. The results from batch cavitation treatment of deinked pulp revealed that the device could treat the pulp with consistency up to 3.8% by weight and decrease attached ink, dirt specks, and macrostickies without addition of deinking chemicals. Hydrophobic colloidal materials, including microstickies after cavitation treatment, became more difficult to attach to hydrophobic surfaces. Continuous cavitation treatment gave similar results to those from batch treatment. Two types of multiple nozzle arrangements, parallel and cross-nozzle modes, decreased dirt specks to the same level as a mill disperser. On the other hand, the reductions of macrostickies by those modes were higher than with the disperser. Because treatment consistency increased more than 3%, treatment efficiency and device performance were significantly improved. This could be a big step toward practical use of cavitation treatment.