Introduction: Cardiometabolic risk factors such as elevated blood pressure, total cholesterol and glycated hemoglobin (HbA1C) in adolescents persist into adulthood and are associated with increased risk for cardiovascular disease and diabetes. These risks are increased when multiple risk factors are present. High school blood drives are a unique opportunity to provide screening for cardiometabolic risk factors at low cost and minimum inconvenience to participants. Methods: Blood pressure (SBP and DPB), total nonfasting cholesterol and HbA1C were measured in volunteer blood donors aged 16-19 years, donating blood between January 2011 and December 2012, through Carter BloodCare in Dallas/Fort Worth, Texas. Cardiometabolic risk factors were classified as elevated (SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg, cholesterol ≥ 200 mg/dL, HbA1C ≥ 6.5%) and borderline or elevated (SBP ≥ 120 mmHg and/or DBP ≥ 80 mmHg, cholesterol ≥ 170 mg/dL, HbA1C ≥ 5.7%). Results: The study included 24,925 donors (11,590 boys and 13,335 girls), including 8.4% African American, 2.2% Asian, 52.7% Caucasian, 24.9% Hispanic and 11.8% other/unknown. Only 33.6% of the entire cohort had no borderline or elevated risk factors (Table). However, 41.6% of females and 51.8% of males had at least 1 borderline or elevated risk factor. When viewed by ethnicity, 48.2% of Caucasians and 45.1% of African Americans had 1 borderline or elevated risk factor, with almost 25 % of African Americans having 2 or more borderline or elevated risk factors. Conclusions: Blood donor screening is confirmed as an opportunity to monitor the prevalence of multiple metabolic risk factors in an ostensibly healthy subset of the population. This scrutiny does identify individuals with multiple risk factors and also reveals ethnic and gender differences.