The sound insulation performance of an electric vehicle’s body system serves as a critical metric for evaluating the noise, vibration, and harshness (NVH) quality of the vehicle. The accurate and efficient prediction of sound insulation performance is foundational for undertaking noise reduction design and optimization. Current engineering practices predominantly rely on Computer-Aided Engineering (CAE) methodologies to address this challenge. However, inherent shortcomings such as low modeling efficiency and difficulty in ensuring prediction accuracy often characterize these approaches. In an effort to overcome these limitations, we propose a decomposition framework for predicting the sound insulation performance of the electric vehicle body system. This framework is established based on a comprehensive analysis of the noise transmission paths within the system. Subsequently, the support vector regression (SVR) method is introduced to construct a machine learning model specifically designed for predicting the sound insulation performance of the body system. This approach aims to mitigate the inherent weaknesses associated with the conventional CAE processes using a ‘data-driven’ paradigm. Furthermore, the Multiple Kernel Learning (MKL) method is used to enhance the processing efficacy of the SVR model. The proposed method is validated using practical application and testing on a specific electric vehicle. The results demonstrate commendable performance in terms of prediction accuracy and robustness. This research contributes to advancing the field by presenting a more effective and reliable approach to predicting the sound insulation performance of electric vehicle body systems, offering valuable insights for noise reduction strategies and optimization efforts in the automotive industry.