Bilateral, multiple joint exercises (MJE) (e.g. squatting) may be preferentially used over unilateral, single joint exercises (SJE) (e.g. leg extension) during rehabilitation following ACL reconstruction. Although MJE's are functional in nature, they also provide an avenue for intra- and inter-limb discrepancies and substitution patterns in joint kinetics. PURPOSE: To determine if side-to-side differences exist in joint kinetics during squatting in uninjured, normal subjects. METHODS: Ten participants (age = 27.4 ± 6.38 yr) performed 3 sets of 10 repetitions of parallel squats using a load of 35% BW. Simultaneous video and force platform data were used to calculate the peak net moments of force produced at the ankle, knee, and hip. A hip/knee moment ratio was computed to determine the relative contribution of the hip and knee extensors. Side-to-side comparisons were performed using paired sample T-tests. RESULTS: The average peak hip/knee moment ratio was 18.7% greater in the non-dominant limb (p = 0.03). The average knee moment was 12.8% greater in the dominant limb (p = 0.01). No significant differences were observed in kinematic variables between limbs and no significant differences were observed between limbs for average hip and ankle moments. CONCLUSION: These results suggest uninjured individuals used different bilateral intersegmental kinetic strategies during the squatting activity. Further study is warranted to assess the effects of these differences in patients during rehabilitation programs following ACL reconstruction. Supported by California Physical Therapy Fund #99-14