Multiple Granular Cell Tumors Research Articles

A light microscopic and immunohistochemical study of a multiple granular cell tumor and review of the literature

A light microscopic and immunohistochemical study of a multiple granular cell tumor and review of the literature

Multiple Cutaneous Granular Cell Tumors and Neurofibromatosis in Childhood

Multiple cutaneous granular cell tumors have been previously reported in only 26 children or adolescents. An association of these tumors with neurofibromatosis has never been reported previously. We describe a 12-year-old black girl with multiple cutaneous granular cell tumors and neurofibromatosis. Although the histogenesis of these tumors is not completely clear, the findings of ultrastructural and immunohistochemical evaluation of our patient's tumors and the associated neurofibromatosis support a neural crest origin for granular cell tumors.

Multiple cutaneous granular cell tumors and neurofibromatosis in childhood. A case report and review of the literature

Multiple cutaneous granular cell tumors and neurofibromatosis in childhood. A case report and review of the literature

Multiple granular cell tumors of the palate

A report of a case of bilateral granular cell tumors of the soft palate is presented. This is an unusual location for the tumor and is the first report of bilateral tumors at this site.

Granular Cell Tumor of Larynx and Bronchus

A patient was seen with an unusual combination of multiple granular cell tumors involving the larynx and the left main bronchus. A review of the reported cases of such tumors in the respiratory tract reveals a significant incidence of multicentricity. Complete excision and careful follow-up are mandatory as local recurrences have been reported. However, the prognosis for patients with these tumors is favorable.

Multiple granular-cell tumors of the ascending colon

Light and electron microscopic study of a case of multiple granular-cell tumor of the ascending colon is presented, and the relevant medical literature is reviewed. It seems that the biologic behavior of this tumor in the colon does not differ from that in other locations. Histologically, a few granular cells are seen in neural tissue in the vicinity of the tumor, suggesting a close relation of the tumor to the neural tissue. Electron-microscopically, the granular cells resemble Schwann cells more closely than neural cells and axons. Histochemically, the granules of the tumor cells show autofluorescence and high activity of acid phosphatase, which was located electron-microscopically in the limiting membranes and matrices of the granules. It is suggested that the granular-cell tumor is a neoplasm of Schwann-cell origin with a unique metabolism that causes acceleration of autophagocytosis and accumulation of ceroidlipofuscin.

Multiple granular cell tumors ("myoblastomas"). Case report with electron microscopic observations and review of the literature.

A case of a 34-year-old woman with three histologically proven coincidental granular cell tumors is reported and documented with electron microscopic observations. The subject of multicentric occurrence of these rumors is reviewed in the literature and the available data and circumstances with a possible bearing on their nature are discussed. From the number of reviewed case reports (550) it appears that the occurrence of multiple granular cell tumors (36) is much more common (7 to 16%) than traditionally believed. Attention is drawn to their benign course. The precise histogenesis of these tumors and the chemical nature of the 160 to 240 A vesicular units of the granules remain unknown. The authors conclude that the granular cells in this instance are of mesenchymal derivation and that the granules of these cells may represent the end result of an obscure metabolic alteration manifested by intracytoplasmic storage of protein and lipoid substances.