Multiple Exchange Research Articles

Research on the Development Experience of the Dairy Futures Market and Exploring the Feasibility of the Dairy Market in China

With the dairy business across the world increasingly growing, a study of how Europe and the US established their dairy futures markets helps to understand whether they will be viable in China. For both of these regions, there are well-established dairy futures markets that play an important role in price risk management for both producers and buyers. This will help us to anticipate what we might face as challenges or opportunities when we introduce such a market in China. The significance of European and American markets is reflected by the various roles played by dairy futures. It highlights the necessity of strong infrastructure, efficient legal frameworks and regulations, vibrant market participation, and information dissemination that is transparent and efficient. It has been a stabilizing element for transparency in European dairy future markets. Various initiatives introduced by the EU have supported the development, including standardization of contract terms and provision of adequate liquidity. In contrast, the United States has multiple exchanges that trade dairy futures where each exchange trades different kinds of dairy contracts. This variety allows for individualization, but it also hinders uniformity in market operations and limits liquidity. In conclusion, we discuss the significance of developing strong infrastructures, effective legal frameworks, and regulations, encouraging active market participation, as well as ensuring transparency and efficiency in information dissemination. Lastly, through an examination of these European and American experiences coupled with the main ingredients underlying their achievements, we can support China to have a robust dairy industry future market.

The safety and efficacy of regional citrate anticoagulation for multiple consecutive therapeutic plasma exchanges with fresh frozen plasma as a replacement solution.

Therapeutic plasma exchange (TPE) is an important blood purification technology and most patients require multiple consecutive TPEs. Regional citrate anticoagulation (RCA) could be used for membrane therapeutic plasma exchange (mTPE). However, there is no research on the metabolic complications of the RCA for patients receiving multiple consecutive mTPEs with fresh frozen plasma (FFP) as a replacement solution. We retrospectively included patients who used RCA for multiple consecutive mTPEs with FFP as a replacement solution in Xijing Hospital from 2020 to 2022. We collected blood gas analysis and electrolyte results before and after mTPE treatment and analysed the anticoagulation effectiveness and metabolic complications of the RCA. A total of 33 patients who underwent 131 mTPE sessions were included, and 129 (98.5%) sessions were successfully completed. Severe hypocalcemia (19.1%) and metabolic alkalosis (58.5%) were frequently observed. In single mTPE sessions, there was a significant decrease in ionized calcium levels and significant increases in serum sodium, potassium, pH, bicarbonate, and base excess (BE) levels compared to pretreatment values. When comparing the values after the last treatment to the baseline values in all 33 patients, the serum sodium, pH, bicarbonate, and BE levels increased significantly, while the ionized calcium decreased significantly. The levels of pH, bicarbonate, and BE increased with the number of mTPE sessions, and the cumulative incidence of metabolic alkalosis reached 95.2% after the fifth treatment according to the Kaplan-Meier survival analysis. RCA is an effective anticoagulation method for patients undergoing mTPE with FFP as a replacement solution. However, the metabolic complications associated with RCA, especially hypocalcemia and metabolic alkalosis, frequently develop in patients who undergo multiple consecutive mTPEs with FFP.

17O NMR spectroscopy reveals CO2 speciation and dynamics in hydroxide-based carbon capture materials.

Carbon dioxide capture technologies are set to play a vital role in mitigating the current climate crisis. Solid-state 17O NMR spectroscopy can provide key mechanistic insights that are crucial to effective sorbent development. In this work, we present the fundamental aspects and complexities for the study of hydroxide-based CO2 capture systems by 17O NMR. We perform static density functional theory (DFT) NMR calculations to assign peaks for general hydroxide CO2 capture products, finding that 17O NMR can readily distinguish bicarbonate, carbonate and water species. However, in application to CO2 binding in two test case hydroxide-functionalised metal-organic frameworks (MOFs):MFU-4l and KHCO3-cyclodextrin-MOF, we find that a dynamic treatment is necessary to obtain agreement between computational and experimental spectra. We therefore introduce a workflow that leverages machine-learning forcefields to capture dynamics across multiple chemical exchange regimes, providing a significant improvement on static DFT predictions. In MFU-4l, we parameterise a two-component dynamic motion of the bicarbonate motif involving a rapid carbonyl seesaw motion and intermediate hydroxyl proton hopping. For KHCO3-CD-MOF, we combined experimental and modelling approaches to propose a new mixed carbonate-bicarbonate binding mechanism and thus, we open new avenues for the study and modelling of hydroxide-based CO2 capture materials by 17O NMR.

Reaction-controlled triple O-isotope exchange trajectories during experimental alteration of olivine

The measurements and application of triple O-isotope system is a relatively new and powerful tool in tracing water-rock interaction, allowing to distinguish the temperature-dependent fractionation from the water amount that interacted with the rock. While the use of 18O/16O fractionation between minerals and fluids is well-established, most natural mineral-water reactions remain uncharacterized in terms of the triple isotope fractionation (17O/16O and18O/16O). The triple O-isotope approach is especially promising when it comes to natural samples, where an array of exchanged samples constrains the fluid endmembers. However, multiple exchange mechanisms are likely to occur between the reacting rock and water, which has not been investigated for triple O-isotopes. This study examines the triple O-isotope exchange between fluid and olivine experimentally, as this is a common reaction in nature and mechanisms/rates of reaction are societally important for CO2 sequestration. Water-olivine reaction in batch experiments was investigated at 275 °C at the saturated water vapor pressure of 59.5 bar. Reactants were loaded at mass ratios 0.6 to 2 and exchanged for periods of time between 44 and 1048 h. Local meteoric water and mantle olivine were taken as the initial reactants. The mineral products are brucite, serpentine and minor magnetite that occur as coatings on unreacted olivine as well as individual crystals. The progress of this dissolution-precipitation reaction was traced with the δD-δ′18O-Δ′17O values of reacted fluids and mineral products. After 1048 h of reaction, ∼50 wt% of unreacted olivine remained. In general, experimental data conforms with the triple O-isotope fractionation factors calculated for the co-existing secondary minerals forming in equilibrium with fluid. However, there is scatter and deviations in the reacted fluid compositions likely driven by the difference in relative rates of secondary mineral formation and changing modal and chemical mineral composition. We observe that brucite and magnetite form abundant aggregates early in the progress of the reaction, while chrysotile forms fine-grained coatings that become abundant later. Since individual mineral-water fractionation 103ln18/16α range over 10 ‰ with θ ranging between 0.51 and 0.53, the dynamic behavior of dissolution-precipitation mechanism during alteration of olivine is the main factor to the “wandering” triple O-isotope trajectories in our relatively short experiments.

Oil prices and exchange rates causality: New evidences from decomposed oil prices shocks and parametric in quantile analysis

In this paper, the researchers reassess the causality between oil prices and exchange rates by applying the parametric quantile analysis to decomposed oil prices shocks and exchange rates returns data of both low income, emerging and developed oil exporting countries from 1993.11 to 2021.10. Unlike the existing researches using the causality in quantile analysis, our study outcomes support the causal relationship from exchange rates to oil prices shocks at upper and lower quantiles in developed oil exporting countries; this is also true regarding the bidirectional causality observed in low income and emerging oil exporting countries .These findings imply that, important positive and negative oil shocks cause extremes changes in the exchange rate returns of low income and emerging oil exporting countries and reciprocally. However only extreme fluctuations of exchange rate returns of developed oil exporting countries such as Norway and Canada can cause oil prices variations. The results of non-causality at middle quantiles also suggest that the monetary authorities in both developing and developed oil exporting countries resist the exchange rates adjustments when oil prices fluctuations are significant. From these results we recommend sound policies in order to mitigate internal and external shocks during crisis, structural reforms that support diversification of energy production by developing other energy sources and reduce crude oil dependence, as well as the whole economy diversification mostly for developing countries and finally, multiple exchange rates to diversify portfolio and hedge the risks associated to oil prices fluctuations for investors. Keywords: Exchange Rates, Oil Prices Shocks, Quantile Causality.

Multivariate probabilistic forecasting of electricity prices with trading applications

This study extends recently introduced neural networks approach, based on a regularized distributional multilayer perceptron (DMLP) technique for a multivariate case electricity price forecasting. The performance of a fully connected architecture and a LSTM architecture of neural networks are tested. Different from previous studies we incorporate dependence between multiple exchanges (EPEX and Nord Pool). The empirical data application analyzes two auctions in the day-ahead electricity market for the United Kingdom market. Along with statistical evaluation of probabilistic forecasts we develop a flexible bidding strategy based on risk-adjusted investor utility function. The trading application leverages the differences of the two exchanges by having long/short positions in both. Our findings demonstrate while DMLP shows similar performance compared to the benchmarks, the algorithm is considerably less computationally costly. LASSO Quantile Regression is better in terms if statistical evaluation of distributional fit, while DMLP outperforms in terms of Sharpe ratio (by 18%) in the trading application.

Black hole singularity from OPE

Eternal asymptotically AdS black holes are dual to thermofield double states in the boundary CFT. It has long been known that black hole singularities have certain signatures in boundary thermal two-point functions related to null geodesics bouncing off the singularities (bouncing geodesics). In this paper we shed light on the manifestations of black hole singularities in the dual CFT. We decompose the boundary CFT correlator of scalar operators using the Operator Product Expansion (OPE) and focus on the contributions from the identity, the stress tensor, and its products. We show that this part of the correlator develops singularities precisely at the points that are connected by bulk bouncing geodesics. Black hole singularities are thus encoded in the analytic behavior of the boundary correlators determined by multiple stress tensor exchanges. Furthermore, we show that in the limit where the conformal dimension of the operators is large, the sum of multi-stress-tensor contributions develops a branch point singularity as predicted by the geodesic analysis. We also argue that the appearance of complexified geodesics, which play an important role in computing the full correlator, is related to the contributions of the double-trace operators in the boundary CFT.

What We See When Invited To Look Differently: Critical Reflections On Socially Engaged Photography

The conversation is the result of multiple exchanges around different projects and contexts of practice undertaken by Anthony Luvera over the course of his career. Driven by a desire to explore Socially Engaged Photography (SEP) within an expanded critical framework, Gary Bratchford and Anthony Luvera discuss the logics of neoliberalism; representational responsibility; the use of data as a mode of address in the context of SEP; the politics of the ‘invitation’; and the triangulated partnership between subject, photographer, and audience as productive space for political engagement.

Self-assembly Ti3C2Tx MXene/ZnCo2O4@ZnO heterostructure with Schottky junction for regulating BIEF to enhance microwave absorption

Currently, heterogenous interface engineering on absorbers is shown to boost the electromagnetic wave absorption (EMA) performance effectively. However, challenges remain in investigating the mechanisms by studying heterojunctions between heterogeneous interfaces. Herein, a self-assembly Ti3C2Tx MXene/ZnCo2O4@ZnO (MZCZ) heterostructure with abundant Schottky heterogenous interfaces generating a controllable built-interface electric field (BIEF) effect is fabricated to achieve exceptional EMA ability. The formative BIEF between the unbalanced distribution charges promotes charge separation and migration, increasing polarization loss. Fortunately, the obtained MZCZ1 exhibits the reflection loss (RL) value of −69.78 dB under the ultralow thickness of 1.501 mm and the optimal minimum RL (RLmin) value of −74.41 dB, respectively. The excellent performance can be ascribed to the multiple polarization loss, conduction loss, natural resonance, and exchange resonance characteristics. Moreover, by the Computer Simulation Technology (CST) software, the designed circular cone and circular truncated cone periodicity structure with the MZCZ1 absorber both exhibit a super-wide effective absorption bandwidth (EAB) covering the whole C, X, and Ku band. This study can pioneer a novel approach to developing functional EMA materials and provide a valuable direction for further study of EMA mechanisms at heterogeneous interfaces.

Investigation into factors controlling groundwater evolution in mining areas with an integrated approach

The study of groundwater evolution is of great significance for water resource protection and management, groundwater pollution control, and ecological environment protection. Experts and scholars have found that the hydrochemical processes and evolutionary patterns of groundwater are determined by both natural processes and human activities. However, there is relatively little research on the evolution of groundwater in mining areas where human activities have a significant impact. Therefore, to study the main controlling factors affecting the hydrogeochemical evolution of groundwater in mining areas, this paper proposes a method combining mixed ratio calculation and multivariate statistical analysis. Firstly, a total of 40 groundwater samples are classified into six clusters via hierarchical cluster analysis. By comprehensively analyzing the spatial location of the samples, it was found that there was no obvious distribution pattern of groundwater in space. Furthermore, the rationality of the cluster analysis is evaluated via principal component analysis. Next, hydrochemical and isotopic analyses were conducted to determine the source of groundwater in the mining area, and a three terminal element mixing model was established to identify the source of pollutants and calculate the terminal element mixing ratio. The research results indicate that groundwater in mining areas is formed by a mixture of shallow bedrock fissure water, deep bedrock fissure water, and rainwater, and the mixing effect is the main factor affecting the evolution of groundwater in mining areas, with a more significant impact than the depth of groundwater circulation. In addition, different types and degrees of water–rock interaction in different regions have altered the hydrochemical characteristics of groundwater in mining areas, such as the dissolution of multiple minerals, cation exchange, and common ion effects. Based on the above analysis results, a water circulation model for the mining area has been established. The findings of this study not only contribute to the protection of shallow fissure groundwater in the study area, but also provide a basis for investigating the groundwater evolution patterns in other metal mines.

Circulation of self-supplied water for significant energy recovery through heat integration

This study introduces an overhead heat-integrated distillation column (OHIDiC), a novel approach that maximizes heat recovery by multiple heat exchanges and product circulation. By utilizing the overhead vapor as a direct heat source, low-temperature feed and product water were used as cooling agents, thereby significantly reducing the condenser duty and reliance on cooling utilities. Additionally, the heated feed transfers heat to the column, leading to a substantial reduction of reboiler heat duty. Some of the heated product water is recycled back to the decanter for product cycling, while the rest is released as the final product. This circulation process ensures a continuous coolant supply, which contributes the reduction of condenser duty. Two processes were considered in this study, utilizing the water product from a non-reactive, and from a reactive separation within the system. When applied to the separation of a water-dodecanol mixture, OHIDiC reduced the condenser duty by 69.21% compared to a traditional distillation column, with a 31.46% reduction in the total utility consumption. When reactive distillation was incorporated into the OHIDiC, the higher overhead vapor temperature facilitated high heat transfer in the multiple heat exchange sections, thereby significantly reducing the total thermal load. This resulted in a reduction of up to 46.96% in total heat duty and a 36.06% decrease in CO2 emissions. These findings confirm that the OHIDiC achieves significant energy savings through the utilization of process-derived substances, with pronounced benefits when the temperature of the overhead vapor becomes higher.

Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.

The cytochrome P450s enzyme family metabolizes ∼80% of small molecule drugs. Variants in cytochrome P450s can substantially alter drug metabolism, leading to improper dosing and severe adverse drug reactions. Due to low sequence conservation, predicting variant effects across cytochrome P450s is challenging. Even closely related cytochrome P450s like CYP2C9 and CYP2C19, which share 92% amino acid sequence identity, display distinct phenotypic properties. Using variant abundance by massively parallel sequencing, we measured the steady-state protein abundance of 7,660 single amino acid variants in CYP2C19 expressed in cultured human cells. Our findings confirmed critical positions and structural features essential for cytochrome P450 function, and revealed how variants at conserved positions influence abundance. We jointly analyzed 4,670 variants whose abundance was measured in both CYP2C19 and CYP2C9, finding that the homologs have different variant abundances in substrate recognition sites within the hydrophobic core. We also measured the abundance of all single and some multiple wild type amino acid exchanges between CYP2C19 and CYP2C9. While most exchanges had no effect, substitutions in substrate recognition site 4 reduced abundance in CYP2C19. Double and triple mutants showed distinct interactions, highlighting a region that points to differing thermodynamic properties between the 2 homologs. These positions are known contributors to substrate specificity, suggesting an evolutionary tradeoff between stability and enzymatic function. Finally, we analyzed 368 previously unannotated human variants, finding that 43% had decreased abundance. By comparing variant effects between these homologs, we uncovered regions underlying their functional differences, advancing our understanding of this versatile family of enzymes.

Energy-loss process in Ni63 betavoltaic batteries

The betavoltaic effect is characterized by multiple random scatterings and high energy density exchange. The conversion of beta-particles’ energy to electric current is a sophisticated process. A GEANT4-based code is used to model the energy-loss mechanisms of emitted electrons from 63Ni radioisotope, considering the physics behind these losses (such as Coulomb scattering, nuclear stopping, and Bethe-Bloch theory) while taking into account self-absorption and backscattering factors. The study indicates the existence of a significant non-ionizing energy-loss of penetrating beta-particles that may stimulate remarkable local heating in the absorbing structure, which results in a degradation in the performance of betavoltaic batteries using 63Ni as nuclear fuel.

A Lankan invasion? An intriguing case of the presence of a Sri Lankan endemic skink on the southwestern Indian Coast

The biota of the Indian subcontinent is a result of Gondwanan vicariance to some extent but largely through multiple faunal exchanges between neighbouring regions. However, in recent times, humans have influenced regional biotas through the human-mediated transport of many generalist species. In this study, we report populations of Lankascincus fallax, a skink species supposedly endemic to Sri Lanka, from the west coast of Kerala in India. We conducted morphological and genetic analysis to ascertain the identity of this species and to check whether the Indian population is monophyletic. We then performed a divergence dating analysis to test whether the presence of this population is a result of ancient dispersal into India or a result of more recent events. Additionally, we used species distribution modelling to test whether the Indian L. fallax is a result of natural dispersal into India during the past (mid-Pliocene to the last glacial maximum) when there were possible land bridges between India and Sri Lanka. We find that the Indian population is nested within the Sri Lankan L. fallax and that this population diverged from the Sri Lankan population very recently, during the Pleistocene. We do not find climatic suitability between the Indian west coast and Sri Lanka under current climatic conditions, or during the past suggesting no suitable dispersal corridors between India and Sri Lanka. Overall, we hypothesize that the Indian populations of L. fallax are likely a result of human-mediated transport into India and subsequent dispersal across the west coast of Kerala.

Transforming how we communicate with victims :moving beyond information provision to a system of communication

This article is based on Victim Support Europe’s policy paper “Transforming how we communicate with victims: moving beyond information provision to a system of communication”, drafted and published in 2022 under the Project INFOVICTIMS 3. The three INFOVICTIMS projects, co-financed by the Criminal Justice Programme of the European Union, were developed and led by the Portuguese Association for Victim Support (Associação Portuguesa de Apoio à Vítima, APAV). As a result of multiple contacts and exchange of knowledge and experiences, a partnership between APAV and the Instituto Brasileiro de Atenção e Apoio Integral às Vítimas (PRÓVÍTIMA) was established. The connection between APAV and ProVítima is characterized by collaborative efforts and synergies to create a more robust and integrated response to the complex challenges associated with victimisation. APAV's expertise in victim support and ProVítima's specialized focus contribute to a collective and coordinated approach to prevention, intervention, and assistance for those affected by crime. This collaboration exemplifies a concerted endeavour to provide holistic support and advocate for the rights and well-being of victims within the Portuguese and Brazilian context. Under this partnership,Infovictims reached Brazil, and ProVítima Institute created the website Infovictims Brazil.

Evaluation of micro-dispersion on oil recovery during low-salinity water-alternating-CO2 processes in sandstone cores: An integrated experimental approach

Low-salinity water (LSW) and CO2 could be combined to perform better in a hydrocarbon reservoir due to their synergistic advantages for enhanced oil recovery (EOR); however, its microscopic recovery mechanisms have not been well understood due to the nature of these two fluids and their physical reactions in the presence of reservoir fluids and porous media. In this work, well-designed and integrated experiments have been performed for the first time to characterize the in-situ formation of micro-dispersions and identify their EOR roles during a LSW-alternating-CO2 (CO2-LSWAG) process under various conditions. Firstly, by measuring water concentration and performing the Fourier transform infrared spectroscopy (FT-IR) analysis, the in-situ formation of micro-dispersions induced by polar and acidic materials was identified. Then, displacement experiments combining with nuclear magnetic resonance (NMR) analysis were performed with two crude oil samples, during which wettability, interfacial tension (IFT), CO2 dissolution, and CO2 diffusion were quantified. During a CO2-LSWAG process, the in-situ formed micro-dispersions dictate the oil recovery, while the presence of clay minerals, electrical double-layer (EDL) expansion and multiple ion exchange (MIE) are found to contribute less. Such formed micro-dispersions are induced by CO2 via diffusion to mobilize the CO2-diluated oil, alter the rock wettability towards more water-wet, and minimize the density contrast between crude oil and water.

Estimation of Exchange rate pass-through in Iran’s multiple exchange rate system

Estimation of Exchange rate pass-through in Iran’s multiple exchange rate system

The crystal engineering of 3d-metal with two tetrazole-phenyl-carboxylate linkers and multiple post-synthetic metal exchange

Ligand with mixed-groups contributes to the construction of special structure motif with novel properties, yet it is challenging to understand and regulate the competitive coordination of different functional groups toward metal ions. Herein, the crystal engineering for MOF construction from two linear di-topic linkers of 4-(1H-tetrazol-5-yl)benzoic acid (H2tzba) and the longer 4′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-carboxylic acid (H2tzbba) featuring dual groups of phenyl-carboxylate and tetrazole, with three typical 3d metal ions (Mn2+, Fe2+ and Zn2+) were investigated. A series of five new MOFs, that are [Mn3(tzba)3(dmf)4]·11dmf (1, dmf = N,N-Dimethylformamide), [Mn(tzba)(H2O)] (2), [Zn2(tzba)2(dmf)]·0.5dmf (3), [Fe2(tzba)2(dmf)]·0.5dmf (4) and [Zn2(tzbbz)(gac)(dmf)2]·1.5dmf (5), were synthesized under solvothermal reactions. The modified solvent template and temperature effects lead to 3D framework of 1 (dmf solution under 433 K) with [Mn3(tz)3(COO)3] nodes and 1D hexagonal channels, while the 2 (water solution under 373 K) posssesses compact pillared-layer motif from [Mn2(tz)2] nodes. Under changed metal salt reactents but same solvent of dmf, the generated 3 and 4 have isoreticular and porous pillared-layer structure constituted of [M2(COO)2] nodes. The use of tzbba coupled with a crucial auxiliary ligand of glycollic acid, leads to 5 as porous pillared-layer MOFs with 1D rounded channels. The porous flexible skeleton of 1 constructed from [Mn3] node with four coordinated dmf facilitates post-synthetic metal exchange of the Mn2+ by radius similar metal ions following priority of Cu2+ < Zn2+ < Ni2+< Co2+, with maximum exchange percentage ranging from 17 % to 69 %. Time dependent ICP-AES analysis revealed the quite wide feasible solvents for post-synthetic metal exchange, as well as the fine control on substituting degree based on soaking temperature and time. Particularly, the compatible introduce of four different metal ions support the potential of preparing bi-, tri-, tetra- and penta- metal MOF crystals, that can not be obtained by traditional solvothermal reactions.

Multiple Parameter Replica Exchange Gaussian Accelerated Molecular Dynamics for Enhanced Sampling and Free Energy Calculation of Biomolecular Systems.

This study introduces a novel method named multiple parameter replica exchange Gaussian accelerated molecular dynamics (MP-Rex-GaMD), building on the Gaussian accelerated molecular dynamics (GaMD) algorithm. GaMD enhances sampling and retrieves free energy information for biomolecular systems by adding a harmonic boost potential to smooth the potential energy surface without the need for predefined reaction coordinates. Our innovative approach advances the acceleration power and energetic reweighting accuracy of GaMD by incorporating a replica exchange algorithm that enables the exchange of multiple parameters, including the GaMD boost parameters of force constant and energy threshold, as well as temperature. Applying MP-Rex-GaMD to the three model systems of dialanine, chignolin, and HIV protease, we demonstrate its superior capability over conventional molecular dynamics and GaMD simulations in exploring protein conformations and effectively navigating various biomolecular states across energy barriers. MP-Rex-GaMD allows users to accurately map free energy landscapes through energetic reweighting, capturing the ensemble of biomolecular states from low-energy conformations to rare high-energy transitions within practical computational time scales.

Novel phylogenomic inference and 'Out of Asia' biogeography of cobras, coral snakes and their allies.

Estimation of evolutionary relationships among lineages that rapidly diversified can be challenging, and, in such instances, inaccurate or unresolved phylogenetic estimates can lead to erroneous conclusions regarding historical geographical ranges of lineages. One example underscoring this issue has been the historical challenge posed by untangling the biogeographic origin of elapoid snakes, which includes numerous dangerously venomous species as well as species not known to be dangerous to humans. The worldwide distribution of this lineage makes it an ideal group for testing hypotheses related to historical faunal exchanges among the many continents and other landmasses occupied by contemporary elapoid species. We developed a novel suite of genomic resources, included worldwide sampling, and inferred a robust estimate of evolutionary relationships, which we leveraged to quantitatively estimate geographical range evolution through the deep-time history of this remarkable radiation. Our phylogenetic and biogeographical estimates of historical ranges definitively reject a lingering former 'Out of Africa' hypothesis and support an 'Out of Asia' scenario involving multiple faunal exchanges between Asia, Africa, Australasia, the Americas and Europe.