Multiple Clear Cell Acanthomas Research Articles

Giant clear cell acanthoma: a case report and a review of the literature

Clear cell acanthoma (CCA) is an uncommon benign epidermal tumor of unknown origin and etiology. It is often solitary, and the presence of multiple CCAs in the same individual is rare. Typically, it presents as a slowly growing plaque or nodule located on the legs with a peripheral scaling collarette. Diagnosis is primarily based on clinical and histopathological findings, with dermoscopy enhancing diagnostic accuracy. The differential diagnosis includes various skin tumors and inflammatory dermatoses. The preferred treatment is surgical excision, as these lesions do not regress spontaneously. We describe a case of a large CCA on the right thigh associated with multiple small nodular lesions scattered across the legs.

Therapeutic and diagnostic considerations in multiple eruptive clear cell acanthoma

Clear cell acanthoma represent a benign solitary epidermal tumor of the clear glycogen containing epithelial cells, which is quite common in dermatologic practice. The etiology of this tumor formation is not known exactly at the moment. Clinically, the lesion appears as a single reddish papule or papule-nodule and the characteristic of this lesion is represented by a peripheral scaling collarette. Although solitary lesions represent the most common form of presentation of the acanthoma with clear cells, less than thirtieth cases of multiple clear cell acanthoma, from two up to four hundred lesions, have been described in the medical literature to date. The diagnosis based on clinical features frequently needs to be supported using a dermoscopy exam and, in most cases, a histopathology exam is required. The treatment consists is complete removal (standard surgical excision, cryotherapy, electrofulguration alone, carbon dioxide laser or shave removal or curettage followed by electrofulguration). For the cases with multiple lesions, cryotherapy, or topical 5- fluorouracil are preferred. We present the case of a 62-year-old male patient, presented to our Dermatology Department for multiple asymptomatic rounded papules and multiple exophytic nodular tumor formations (approximate fifteen), on the lower extremities, which had occurred approximately two years previously and gradually increased in number.

Multiple clear‐cell acanthomas

Clear-cell acanthoma (CCA) usually presents as a solitary lesion involving the lower extremities. The abrupt onset of multiple CCA has been rarely reported. Such presentation may impose clinical diagnostic and therapeutic challenges. A 52-year-old man with multiple CCA is presented in this communication. The value of dermoscopy has been demonstrated in the setting of CCA. However, because of the unusual clinical presentation reflecting confocal microscopy was also performed in this case to enhance the accuracy of the clinical and dermoscopic diagnosis.

Multiple eruptive clear cell acanthoma

Clear cell acanthoma is a rare solitary benign epidermal tumor of unknown etiology. The disease arises in the middle-age, with no sex predominance. It appears as a single reddish papule or papule-nodule and a peripheral scaling collarette is characteristic. Although solitary lesions are the rule, less than 30 cases of multiple Clear cell acanthoma have been described in the literature to date. We report an unusual case of a healthy 74-year-old male with multiple clear cell acanthoma on the lower extremities treated successfully with cryotherapy. Despite significant progress in treatment of clear cell acanthoma, cryotherapy, based on liquid nitrogen, remains an important alternative in treating multiple clear cell acanthomas.

Multiple clear cell acanthomas in association with hepatitis C: A novel presentation

Multiple clear cell acanthomas in association with hepatitis C: A novel presentation

Multiple disseminierte Klarzellakanthome

Multiple Klarzellakanthome stellen eine ungewöhnliche klinische Manifestationsvariante dieser solitär gut charakterisierten benignen, histologisch hellzelligen Akanthome dar. Da auch ein psoriasiformes Entzündungsmuster regelmäßig nachweisbar ist, stellt sich die Frage nach einer primär neoplastischen oder entzündlichen Genese. Diese Alternativen können auch als Enden eines klinischen Spektrums mit gemeinsamem histologischem Grundmuster betrachtet werden.

Clear Cell Acanthoma Successfully Treated with a Carbon Dioxide Laser

The treatment of choice for clear cell acanthoma (CCA) is excision. Resolution after cryotherapy has also been reported but requires three to four courses of treatment. To demonstrate three CCA lesions in two patients successfully treated with a carbon dioxide (CO2) laser. Under local anesthesia, these lesions were vaporized by using a CO2 laser in the Silktouch mode with a spot size of 5 mm and a fluence of 20 J/cm2. Two to six passes, as needed, were delivered until the tumor was completely removed. Pain was minimal or nonexistent during and after the operation. No postoperative edema was noted. The wounds healed satisfactorily without scarring. No sign of recurrence was found following operation. The CO2 laser has the advantages of requiring only one course, precise tumor removal, a relatively bloodless surgical field, a short operation time, and less or no postoperative pain and edema. Postoperative wound care is convenient and easy with hydrocolloid and alginate dressings. The patient's quality of life is less adversely affected. The CO2 laser may be appropriate for multiple CCAs, giant CCA, CCA overlying or near joints, CCA refractory to cryotherapy, patients on anticoagulants, and those who cannot tolerate pain from cryotherapy, especially children and the elderly.

Clear Cell Acanthoma Successfully Treated with a Carbon Dioxide Laser

Background The treatment of choice for clear cell acanthoma (CCA) is excision. Resolution after cryotherapy has also been reported but requires three to four courses of treatment. Objective To demonstrate three CCA lesions in two patients successfully treated with a carbon dioxide (CO2) laser. Methods Under local anesthesia, these lesions were vaporized by using a CO2 laser in the Silktouch mode with a spot size of 5 mm and a fluence of 20 J/cm2. Two to six passes, as needed, were delivered until the tumor was completely removed. Results Pain was minimal or nonexistent during and after the operation. No postoperative edema was noted. The wounds healed satisfactorily without scarring. No sign of recurrence was found following operation. Conclusion The CO2 laser has the advantages of requiring only one course, precise tumor removal, a relatively bloodless surgical field, a short operation time, and less or no postoperative pain and edema. Postoperative wound care is convenient and easy with hydrocolloid and alginate dressings. The patient's quality of life is less adversely affected. The CO2 laser may be appropriate for multiple CCAs, giant CCA, CCA overlying or near joints, CCA refractory to cryotherapy, patients on anticoagulants, and those who cannot tolerate pain from cryotherapy, especially children and the elderly.

Multiple Klarzellakanthome

Clear cell acanthoma is a rare, slow-growing benign epidermal tumour of adulthood. The prediction site of this usually solitary lesion is the distal part of the leg. Multiple clear cell acanthomas are very rare and are also found in other locations besides the typical site of predilection. In this paper we report on a 52-year-old man who--over a period of more than 20 years--had developed more than 100 of these tumours in all parts of his body. Although the histological diagnosis is easy, clinical recognition often proves difficult, especially in cases of multiple lesions. Different kinds of therapy for solitary and multiple lesions are discussed.

Successful Cryotherapic Treatment and Overview of Multiple Clear Cell Acanthomas

Clear cell acanthoma (CCA) is a usually solitary benign epidermal-tumor. Multiple lesions are infrequently reported. A case of multiple eruptive CCA is reported in which a successful cryotherapic treatment was performed. A 59-year-old man with varicose veins and dry skin presented with 17 eruptive asymptomatic papulo-nodular lesions on both legs. Two lesions were excised with a histologically confirmed diagnosis of CCA. Other lesions were treated with liquid nitrogen. All the lesions resolved with minimal residual scarring after three to four treatments. Multiple CCA is a rare condition; fewer than 20 cases having been described. The presence of associated conditions like dry skin and varicose veins are discussed. Because of the tendency of persistence of the lesions, cryotherapic treatment may be a useful method of therapy.

Multiple Clear Cell Acanthomas

A case of multiple clear cell acanthomas in a 64-year-old woman is reported. The clinical and histological findings of this rare entity are consistent with the hypothesis that clear cell acanthomas are benign epidermal tumors. An ultrastructural study was performed with special emphasis on the melanocytic-keratinocytic interaction.

Multiple clear cell acanthomas: Case report and delineation of basement membrane zone antigens

A case of multiple clear cell acanthomas is described with a review of the literature. This benign glycogen-rich epidermal tumor is generally unable to accept melanin and lacks phosphorylase or cytochrome oxidase activity. However, the basement membrane zone appears antigenically normal, as documented by the presence of epidermolysis bullosa acquisita antigen, bullous pemphigoid antigen, heparan sulfate proteoglycan, type IV collagen, and laminin by immunofluorescence microscopy.

Multiple Clear-Cell Acanthoma and Ichthyosis

One patient with lamellar ichthyosis and one patient with ichthyosis vulgaris, both with multiple clear-cell acanthomas on the lower extremities, were studied. Histologic examination showed the typical findings of clear-cell acanthoma, plus intraepidermal nests composed of cell debris and inflammatory cells. Histochemical studies revealed increased dendritic cells with intense nucleotide triphosphatase and acid phosphatase activities. The dendritic cells also contained neutral lipids, well demonstrated by oil red O stain. Electron microscopic examination revealed, in addition to glycogen-containing epidermal cells, dendritic cells and processes in the intercellular spaces. Although indeterminate dendritic cells were found, many contained Langerhans granules and lysosomes. Leukocytes and products of cell degradation were seen in the intercellular spaces, often in relation to the leukocyte nests. Mast cells were observed in the epidermis.